Lipid nanocapsule functionalization by lipopeptides derived from human papillomavirus type-16 capsid for nucleic acid delivery into cancer cells

2013 ◽  
Vol 454 (2) ◽  
pp. 756-764 ◽  
Author(s):  
M. Weyland ◽  
A. Griveau ◽  
J. Bejaud ◽  
J-P. Benoit ◽  
P. Coursaget ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Nucleic Acid ◽  
Cancer Cells ◽  
Nucleic Acid Delivery ◽  
Human Papillomavirus Type 16

scholarly journals p53 Is Regulated in a Biphasic Manner in Hypoxic Human Papillomavirus Type 16 (HPV16)-Positive Cervical Cancer Cells

2020 ◽  
Vol 21 (24) ◽  
pp. 9533
Author(s):  
Linhan Zhuang ◽  
Regina Ly ◽  
Frank Rösl ◽  
Martina Niebler
Keyword(s):  
Human Papillomavirus ◽  
Cancer Cells ◽  
Dynamic Regulation ◽  
Cellular Adaptation ◽  
Hpv16 E6 ◽  
Human Papillomavirus Type 16 ◽  
Hypoxic Conditions ◽  
Cervical Cancer Cells ◽  
Adaptation Processes ◽  
The Impact

Although the effect of hypoxia on p53 in human papillomavirus (HPV)-positive cancer cells has been studied for decades, the impact of p53 regulation on downstream targets and cellular adaptation processes during different periods under hypoxia remains elusive. Here, we show that, despite continuous repression of HPV16 E6/E7 oncogenes, p53 did not instantly recover but instead showed a biphasic regulation marked by further depletion within 24 h followed by an increase at 72 h. Of note, during E6/E7 oncogene suppression, lysosomal degradation antagonizes p53 reconstitution. Consequently, the transcription of p53 responsive genes associated with senescence (e.g., PML and YPEL3) cannot be upregulated. In contrast, downstream genes involved in autophagy (e.g., DRAM1 and BNIP3) were activated, allowing the evasion of senescence under hypoxic conditions. Hence, dynamic regulation of p53 along with its downstream network of responsive genes favors cellular adaptation and enhances cell survival, although the expression of the viral E6/E7-oncogenes as drivers for proliferation remained inhibited under hypoxia.

Identification of Differentially Expressed Genes in Human Papillomavirus Type-16 Infected Oral Cancer Cells

2001 ◽  
Vol 124 (6) ◽  
pp. 663-668 ◽  
Author(s):  
Jimmy J. Brown ◽  
Min Qin ◽  
Lorraine William-Smith ◽  
Joan F. Coker ◽  
Heng Zhou ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Oral Cancer ◽  
Cancer Cells ◽  
Differentially Expressed Genes ◽  
Differentially Expressed ◽  
Human Papillomavirus Type 16 ◽  
Oral Cancer Cells

scholarly journals The effect of andrographolide on Human papillomavirus type 16 (HPV16) positive cervical cancer cells (SiHa)

2012 ◽  
Vol 16 ◽  
pp. e80
Author(s):  
S. Fangkham ◽  
T. Ekalaksananan ◽  
C. Aromdee ◽  
S. Seubsasana ◽  
B. Kongyingyoes ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Cancer Cells ◽  
Human Papillomavirus Type 16 ◽  
Cervical Cancer Cells
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