A Tanshinone IIA loaded hybrid nanocomposite with enhanced therapeutic effect for otitis media

Neither aureomycin nor penicillin given to children with pre-eruptive rubeola or begun on the first day of rash seems to have any definite therapeutic effect on the course of the primary disease. The temperature dropped earlier in the patients treated with aureomycin or penicillin than in the untreated control group. Aureomycin and penicillin were effective against otitis media and pneumonia present on admission and on the complications which developed during the disease. Aureomycin and penicillin are useful in the prevention and cure of secondary infection in rubeola.

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Therapeutic Effect of Tanshinone IIA on Liver Fibrosis and the Possible Mechanism: A Preclinical Meta-Analysis

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2019/7514046 ◽

2019 ◽

Vol 2019 ◽

pp. 1-13

Author(s):

Qingji Ying ◽

Yangyang Teng ◽

Jing Zhang ◽

Zhenzhai Cai ◽

Zhanxiong Xue

Keyword(s):

Liver Fibrosis ◽

Liver Function ◽

Therapeutic Effect ◽

Animal Studies ◽

Meta Analysis ◽

Underlying Mechanism ◽

Tanshinone Iia ◽

Drug Preparation ◽

Clinical Drug

Background. Liver fibrosis is a serious human health problem, and there is a need for specific antifibrosis drugs in the clinic. Tanshinone IIA has recently been reported to have a role in the treatment of liver fibrosis. However, the evidence supporting its antifibrotic effect is not sufficient, and the underlying mechanism is not clear. We thus performed this meta-analysis of animal research to assess the therapeutic effect of tanshinone IIA on liver fibrosis and analyzed the possible associated mechanism to provide a reference for further clinical drug preparation and clinical research. Methods. We collect related articles from the databases PubMed, Web of Science, Embase, Wanfang, VIP, and CNKI. The quality of the included studies was evaluated according to the SYRCLE risk of bias tool for animal studies. Data were analyzed using RavMan 5.3 and Stata 12.0 software. Results. A total of 404 articles were retrieved from the databases. After screening, 11 articles were included in the analysis. The included studies’ methodological quality was generally low, and an obvious publication bias was found. The results showed that tanshinone IIA significantly improved liver function in experimental animals and reduced the level of liver fibrosis by reducing inflammation and inhibiting immunity, antiapoptotic processes, and HSC activation. Conclusion. Tanshinone IIA can effectively improve liver fibrosis and liver function in animal models and is worthy of future higher quality animal studies and clinical drug trials.

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The therapeutic effect of tanshinone IIA onPropionibacterium acnes-induced inflammation in vitro

Dermatologic Therapy ◽

10.1111/dth.12716 ◽

2018 ◽

Vol 31 (6) ◽

pp. e12716 ◽

Cited By ~ 5

Author(s):

Yifan Li ◽

Yali Zhou

Keyword(s):

Therapeutic Effect ◽

Tanshinone Iia

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Exploring the mechanisms underlying the therapeutic effect of Salvia miltiorrhiza on diabetic nephropathy using network pharmacology and molecular docking

Bioscience Reports ◽

10.1042/bsr20203520 ◽

2021 ◽

Author(s):

Lili Zhang ◽

Lin Han ◽

Xinmiao Wang ◽

Yu Wei ◽

Jinghui Zheng ◽

...

Keyword(s):

Diabetic Nephropathy ◽

Molecular Docking ◽

Therapeutic Effect ◽

Function Analysis ◽

Salvia Miltiorrhiza ◽

Tanshinone Iia ◽

Network Pharmacology ◽

Pathway Enrichment Analysis ◽

Ppi Network ◽

Active Ingredients

The mechanisms underlying the therapeutic effect of Salvia miltiorrhiza (SM) on diabetic nephropathy (DN) were examined using a systematic network pharmacology approach and molecular docking. The Traditional Chinese Medicine Systems Pharmacology (TCMSP) database was used to screen active ingredients of SM. Targets were obtained using the SwissTargetPrediction and TCMSP databases. Proteins related to DN were retrieved from the GeneCards and DisGeNET databases. A protein–protein interaction (PPI) network was constructed using common SM/DN targets in the STRING database. The Metascape platform was used for GO function analysis, and the Cytoscape plug-in ClueGO was used for KEGG pathway enrichment analysis. Molecular docking was performed using iGEMDOCK and AutoDock Vina software. Pymol and LigPlos were used for network mapping. Sixty-six active ingredients and 189 targets of SM were found. Sixty-four targets overlapped with DN-related proteins. The PPI network revealed that AKT1, VEGFA, IL6, TNF, MAPK1, TP53, EGFR, STAT3, MAPK14, and JUN were the 10 most relevant targets. Go and KEGG analyses revealed that the common targets of DN and SM were mainly involved in advanced glycation end products, oxidative stress, inflammatory response, and immune regulation. Molecular docking revealed that potential DN-related targets, includingTNF, NOS2, and AKT1, more stably bound with salvianolic acid B than with tanshinone IIA. In conclusion, this study revealed the active components and potential molecular therapeutic mechanisms of SM in DN and provides a reference for the wide application of SM in clinically managing DN.

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