Choline and amino acid based biocompatible ionic liquid mediated transdermal delivery of the sparingly soluble drug acyclovir

2020 ◽  
Vol 582 ◽  
pp. 119335 ◽  
Author(s):  
Md. Rafiqul Islam ◽  
Md. Raihan Chowdhury ◽  
Rie Wakabayashi ◽  
Yoshiro Tahara ◽  
Noriho Kamiya ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Amino Acid ◽  
Transdermal Delivery ◽  
Sparingly Soluble Drug

scholarly journals Ionic Liquid-In-Oil Microemulsions Prepared with Biocompatible Choline Carboxylic Acids for Improving the Transdermal Delivery of a Sparingly Soluble Drug

Pharmaceutics ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 392 ◽  
Author(s):  
Md. Rafiqul Islam ◽  
Md. Raihan Chowdhury ◽  
Rie Wakabayashi ◽  
Noriho Kamiya ◽  
Muhammad Moniruzzaman ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Transdermal Delivery ◽  
Drug Carrier ◽  
Skin Irritation ◽  
Skin Barrier ◽  
Biologically Active ◽  
Skin Barrier Function ◽  
Polar Phase ◽  
Sparingly Soluble Drug

The transdermal delivery of sparingly soluble drugs is challenging due to of the need for a drug carrier. In the past few decades, ionic liquid (IL)-in-oil microemulsions (IL/O MEs) have been developed as potential carriers. By focusing on biocompatibility, we report on an IL/O ME that is designed to enhance the solubility and transdermal delivery of the sparingly soluble drug, acyclovir. The prepared MEs were composed of a hydrophilic IL (choline formate, choline lactate, or choline propionate) as the non-aqueous polar phase and a surface-active IL (choline oleate) as the surfactant in combination with sorbitan laurate in a continuous oil phase. The selected ILs were all biologically active ions. Optimized pseudo ternary phase diagrams indicated the MEs formed thermodynamically stable, spherically shaped, and nano-sized (<100 nm) droplets. An in vitro drug permeation study, using pig skin, showed the significantly enhanced permeation of acyclovir using the ME. A Fourier transform infrared spectroscopy study showed a reduction of the skin barrier function with the ME. Finally, a skin irritation study showed a high cell survival rate (>90%) with the ME compared with Dulbecco’s phosphate-buffered saline, indicates the biocompatibility of the ME. Therefore, we conclude that IL/O ME may be a promising nano-carrier for the transdermal delivery of sparingly soluble drugs.

scholarly journals Kinetics of Mixed Amino Acid and Ionic Liquid on CO2 Hydrate Formation

2019 ◽  
Vol 495 ◽  
pp. 012073 ◽  
Author(s):  
Cornelius B. Bavoh ◽  
Bhajan Lal ◽  
Joel Ben-Awuah ◽  
Muhammad Saad Khan ◽  
Grace Ofori-Sarpong
Keyword(s):  
Ionic Liquid ◽  
Amino Acid ◽  
Hydrate Formation ◽  
Kinetics Of

Studies on Volumetric Properties of Concentrated Aqueous Amino Acid Ionic Liquid [C3mim][Glu]

2009 ◽  
Vol 54 (3) ◽  
pp. 1110-1114 ◽  
Author(s):  
Jing Tong ◽  
Qing-Shan Liu ◽  
Wei Guan ◽  
Jia-Zhen Yang
Keyword(s):  
Ionic Liquid ◽  
Amino Acid ◽  
Volumetric Properties ◽  
Amino Acid Ionic Liquid

Enhancing rice straw compost with an amino acid-derived ionic liquid as additive

2021 ◽  
pp. 126387
Author(s):  
Huanhuan Ma ◽  
Ian Beadham ◽  
Wenquan Ruan ◽  
Changbo Zhang ◽  
Yun Deng
Keyword(s):  
Ionic Liquid ◽  
Amino Acid ◽  
Rice Straw

Physicochemical investigations of amino acid ionic liquid based inclusion complex probed by spectral and molecular docking techniques

2019 ◽  
Vol 291 ◽  
pp. 111255 ◽  
Author(s):  
Koyeli Das ◽  
Bhaswati Sarkar ◽  
Pritam Roy ◽  
Chandana Basak ◽  
Ranadhir Chakraborty ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Molecular Docking ◽  
Amino Acid ◽  
Inclusion Complex ◽  
Amino Acid Ionic Liquid
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