Effects of porosity on drug release kinetics of swellable and erodible porous pharmaceutical solid dosage forms fabricated by hot melt droplet deposition 3D printing

In this work, modified-release solid dosage forms were fabricated by adjusting geometrical properties of solid dosage forms through hot-melt 3D extrusion (3D HME). Using a 3D printer with air pressure driving HME system, solid dosage forms containing ibuprofen (IBF), polyvinyl pyrrolidone (PVP), and polyethylene glycol (PEG) were printed by simultaneous HME and 3D deposition. Printed solid dosage forms were evaluated for their physicochemical properties, dissolution rates, and floatable behavior. Results revealed that IBF content in the solid dosage form could be individualized by adjusting the volume of solid dosage form. IBF was dispersed as amorphous state with enhanced solubility and dissolution rate in a polymer solid dosage form matrix. Due to absence of a disintegrant, sustained release of IBF from printed solid dosage forms was observed in phosphate buffer at pH 6.8. The dissolution rate of IBF was dependent on geometric properties of the solid dosage form. The dissolution rate of IBF could be modified by merging two different geometries into one solid dosage form. In this study, the 3D HME process showed high reproducibility and accuracy for preparing dosage forms. API dosage and release profile were found to be customizable by modifying or combining 3D modeling.

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Molecular interactions, internal structure and drug release kinetics of rationally developed polymer–lipid hybrid nanoparticles

Journal of Controlled Release ◽

10.1016/j.jconrel.2008.02.014 ◽

2008 ◽

Vol 128 (1) ◽

pp. 60-70 ◽

Cited By ~ 54

Author(s):

Yongqiang Li ◽

Ho Lun Wong ◽

Adam J. Shuhendler ◽

Andrew M. Rauth ◽

Xiao Yu Wu

Keyword(s):

Drug Release ◽

Internal Structure ◽

Molecular Interactions ◽

Release Kinetics ◽

Hybrid Nanoparticles ◽

Drug Release Kinetics ◽

Kinetics Of

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A New Method for Evaluating Actual Drug Release Kinetics of Nanoparticles inside Dialysis Devices via Numerical Deconvolution

Journal of Controlled Release ◽

10.1016/j.jconrel.2016.09.031 ◽

2016 ◽

Vol 243 ◽

pp. 11-20 ◽

Cited By ~ 22

Author(s):

Yousheng Zhou ◽

Chunsheng He ◽

Kuan Chen ◽

Jieren Ni ◽

Yu Cai ◽

...

Keyword(s):

Drug Release ◽

Release Kinetics ◽

New Method ◽

Drug Release Kinetics ◽

Numerical Deconvolution ◽

Kinetics Of

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Development and Evaluation of Amorphous Oral Thin Films Using Solvent-Free Processes: Comparison between 3D Printing and Hot-Melt Extrusion Technologies

Pharmaceutics ◽

10.3390/pharmaceutics13101613 ◽

2021 ◽

Vol 13 (10) ◽

pp. 1613

Author(s):

Jiaxiang Zhang ◽

Anqi Lu ◽

Rishi Thakkar ◽

Yu Zhang ◽

Mohammed Maniruzzaman

Keyword(s):

Thin Films ◽

3D Printing ◽

Drug Release ◽

Hot Melt Extrusion ◽

Dosage Forms ◽

Solvent Free ◽

Melt Extrusion ◽

Physico Chemical ◽

3D Printed ◽

Hot Melt

Conventional oral dosage forms may not always be optimal especially for those patients suffering from dysphasia or difficulty swallowing. Development of suitable oral thin films (OTFs), therefore, can be an excellent alternative to conventional dosage forms for these patient groups. Hence, the main objective of the current investigation is to develop oral thin film (OTF) formulations using novel solvent-free approaches, including additive manufacturing (AM), hot-melt extrusion, and melt casting. AM, popularly recognized as 3D printing, has been widely utilized for on-demand and personalized formulation development in the pharmaceutical industry. Additionally, in general active pharmaceutical ingredients (APIs) are dissolved or dispersed in polymeric matrices to form amorphous solid dispersions (ASDs). In this study, acetaminophen (APAP) was selected as the model drug, and Klucel™ hydroxypropyl cellulose (HPC) E5 and Soluplus® were used as carrier matrices to form the OTFs. Amorphous OTFs were successfully manufactured by hot-melt extrusion and 3D printing technologies followed by comprehensive studies on the physico-chemical properties of the drug and developed OTFs. Advanced physico-chemical characterizations revealed the presence of amorphous drug in both HME and 3D printed films whereas some crystalline traces were visible in solvent and melt cast films. Moreover, advanced surface analysis conducted by Raman mapping confirmed a more homogenous distribution of amorphous drugs in 3D printed films compared to those prepared by other methods. A series of mathematical models were also used to describe drug release mechanisms from the developed OTFs. Moreover, the in vitro dissolution studies of the 3D printed films demonstrated an improved drug release performance compared to the melt cast or extruded films. This study suggested that HME combined with 3D printing can potentially improve the physical properties of formulations and produce OTFs with preferred qualities such as faster dissolution rate of drugs.

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