Sinomenine-phenolic acid coamorphous drug systems: Solubilization, sustained release, and improved physical stability

Sustained release Carvedilol matrix tablets constituting Kollidon SR were developed in this study in an attempt to investigate the effect of release modifiers on the release profile of Carvedilol from matrix. Three matrix tablet formulations were prepared by direct compression of Kollidon SR in combination with release modifier (HPMC and Microcrystalline Cellulose) and magnesium stearate. Tablets containing only Kollidon SR with the active ingredient demonstrated a rapid rate of drug release. Incorporation of HPMC in the matrix tablet prolonged the release of drug but incorporation of Microcrystalline Cellulose showed superimposable release pattern with an initial burst effect as confirmed by mean dissolution time and Higuchi release rate data. After 7 hours of dissolution, Carvedilol release from the matrix systems were 91.42%, 83.41%, from formulation F1 and F2 respectively. Formulation F3 exhibited 100 % release at 4 hours. All the tablet formulations showed acceptable pharmaco-technical properties and complied with the in-house specifications for tablet weight variation, friability, hardness, thickness, and diameter. Prepared tablets also showed sustained release property for carvedilol. The drug release mechanism from the matrix tablets of F1 and F2 was found to be followed by Fickian and F3 by Non-Fickian mechanism.DOI: <a href="http://dx.doi.org/10.3329/icpj.v1i8.11095">http://dx.doi.org/10.3329/icpj.v1i8.11095</a> International Current Pharmaceutical Journal 2012, 1(8): 186-192

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Suppression of an isolated population of the mosquito vectorAedes polynesiensison the atoll of Tetiaroa, French Polynesia, by sustained release ofWolbachia-incompatible male mosquitoes

10.1603/ice.2016.114243 ◽

2016 ◽

Author(s):

Hervé C. Bossin

Keyword(s):

Sustained Release ◽

French Polynesia ◽

Isolated Population ◽

Male Mosquitoes

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Dental Drug-Delivery Devices: Local and Sustained-Release Applications

Critical Reviews in Therapeutic Drug Carrier Systems ◽

10.1615/critrevtherdrugcarriersyst.v16.i5.10 ◽

1999 ◽

Vol 16 (5) ◽

pp. 36 ◽

Cited By ~ 21

Author(s):

Doron Steinberg ◽

Michael Friedman

Keyword(s):

Drug Delivery ◽

Sustained Release ◽

Drug Delivery Devices

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Formulation Optimization of Sustained Release Resinate Microcapsules of Tramadol Hydrochloride by Using 3/2 Factorial Design

International Journal of Pharmaceutical and Phytopharmacological Research ◽

10.24896/eijppr.2016621 ◽

2017 ◽

Vol 6 (2) ◽

pp. 57

Author(s):

Kamble Ravindra K. ◽

Chauhan Chetan S. ◽

Kamble Priyadarshani R. ◽

Naruka Pushpendra S.

Keyword(s):

Drug Delivery ◽

Ion Exchange ◽

Sustained Release ◽

Factorial Design ◽

Linear Regression Analysis ◽

Extended Period ◽

Multiple Linear Regression Analysis ◽

Water Soluble ◽

Tramadol Hydrochloride ◽

Release Drug

The main aim of the present work was to develop the microcapsules of tramadol hydrochloride for the oral sustained release drug delivery. Tramadol hydrochloride a BCS class I drug a centrally acting synthetic analgesic was complexed with Indion 254 ion exchange resin. The microcapsules were prepared by encapsulating the prepared resinates by o/o solvent evaporation technique. In the investigation 32 full factorial design was used to investigate the joint influence of two formulation variable amount of eudragit RS 100 and plasticized PEG 400. The results of multiple linear regression analysis indicated that for obtaining a sustained release drug delivery the optimum concentrations of both the plasticizer and coating solution to be used. The factorial models were used to prepare optimized microcapsules and optimized formulations showed sustained release profiles for the extended period of more than 12 hrs. From the present investigations concluded that resinate microcapsules of highly water soluble drug can provide controlled release of drug for extended period.Key Words: Tramadol hydrochloride, ion exchange resinate, microcapsules, sustained release

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Photostability Study on Character and Antioxidant Activity of Tomato Extract (Solanum lycopersicum l.) in Nanostructured Lipid Carrier (NLC) and Conventional Creame

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v7i1.8919 ◽

2017 ◽

Vol 7 (1) ◽

Cited By ~ 1

Author(s):

Noorma Rosita ◽

Dewi Haryadi ◽

Tristiana Erawati ◽

Rossa Nanda ◽

Widji Soeratri

Keyword(s):

Antioxidant Activity ◽

Physical Stability ◽

Nanostructured Lipid Carrier ◽

Uvb Radiation ◽

K Value ◽

Antioxidant Power ◽

Solanum Lycopersicum L ◽

Tomato Extract ◽

Dpph Method ◽

High Shear Homogenization

The aim of this study was to investigate the ability of NLC in increasing photostability of tomato extract in term of antioxidant activity. Photostability testing on antioxidant activity of samples were conducted by accelerating method using UVB radiation 32.400 joule for 21 hours radiation. Antioxidant activity was measured by DPPH method. NLC was made by High Shear Homogenization (HPH) method at 24000 rpm for 4 cycles, while conventional creame was made by low speed at 400 rpm. The product were characterized include: pH, viscosity, and particle size. There were had difference characters and physical stability. NLC had smaller size, more homogenous and more stable than conventional creame. It was known that stability of antioxidant activity of tomato extract in NLC system higher than in conventional creame. That was showed with k value, as constanta of rate scavenging activity decreasing in antioxidant power between time (Sigma 2-tail less than 0.005) of NLC and conventional creame were: 2.03x10-2 %/hour ±0.08 (3.94) and 4.71x 10-2 %/ hour ±0.23 (4.88) respectively.

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