Formulation Optimization of Sustained Release Resinate Microcapsules of Tramadol Hydrochloride by Using 3/2 Factorial Design

2017 ◽  
Vol 6 (2) ◽  
pp. 57
Author(s):  
Kamble Ravindra K. ◽  
Chauhan Chetan S. ◽  
Kamble Priyadarshani R. ◽  
Naruka Pushpendra S.
Keyword(s):  
Drug Delivery ◽  
Ion Exchange ◽  
Sustained Release ◽  
Factorial Design ◽  
Linear Regression Analysis ◽  
Extended Period ◽  
Multiple Linear Regression Analysis ◽  
Water Soluble ◽  
Tramadol Hydrochloride ◽  
Release Drug

The main aim of the present work was to develop the microcapsules of tramadol hydrochloride for the oral sustained release drug delivery. Tramadol hydrochloride a BCS class I drug a centrally acting synthetic analgesic was complexed with Indion 254 ion exchange resin. The microcapsules were prepared by encapsulating the prepared resinates by o/o solvent evaporation technique. In the investigation 32 full factorial design was used to investigate the joint influence of two formulation variable amount of eudragit RS 100 and plasticized PEG 400. The results of multiple linear regression analysis indicated that for obtaining a sustained release drug delivery the optimum concentrations of both the plasticizer and coating solution to be used. The factorial models were used to prepare optimized microcapsules and optimized formulations showed sustained release profiles for the extended period of more than 12 hrs. From the present investigations concluded that resinate microcapsules of highly water soluble drug can provide controlled release of drug for extended period.Key Words: Tramadol hydrochloride, ion exchange resinate, microcapsules, sustained release

scholarly journals FORMULATION DEVELOPMENT AND CHARACTERIZATION OF GELUCIRE BEADS OF ANTIHYPERTENSIVE DRUG FOR FLOATING DRUG DELIVERY SYSTEM USING 32 FACTORIAL DESIGNS

2021 ◽  
pp. 150-156
Author(s):  
KHUSHBOO RANKA ◽  
KAMAL S RATHORE
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Loading ◽  
Linear Regression Analysis ◽  
Extended Period ◽  
Multiple Linear Regression Analysis ◽  
Water Soluble ◽  
Tween 20 ◽  
Formulation Development ◽  
Floating Drug Delivery

Objective: The aim of this study was to design and to optimize lipid based beads for multiunit floating drug delivery of ramipril. Methods: The beads prepared by melt-solidification method. In the investigation 32 full factorial design was used to investigate the joint influence of two formulation variable amount of Gelucire (X1) and Tween 20 (X2) as independent variable and the percentage drug release in 1 (Y1), 6 (Y2), and 12 h (Y3) as dependent variable. Gelucire 43/01 has chosen for release retardant and Tween 20 for solubility enhancement and drug loading agent. Results: The results of multiple linear regression analysis indicated that for obtain a floating drug delivery, the optimum concentrations of both the lipid and drug loading agent should be used. The factorial models were used to prepare optimized floating beads and optimized formulations showed controlled release profiles for the extended period of more than 12 h. Conclusion: From the study, it was concluded that beads of Gelucire for sparingly water-soluble drug ramipril can provide controlled release for extended period.

Preparation and Evaluation of Chitosin-Coated Alginate/Gelatin Microspheres for Sustained-Release Drug Delivery System In Vitro

2013 ◽  
Vol 651 ◽  
pp. 227-231
Author(s):  
Qiang Song Wang ◽  
Yuan Lu Cui ◽  
Tian Jiao Dong
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Water Soluble ◽  
Average Particle ◽  
Gelatin Microspheres ◽  
Release Drug ◽  
Ft Ir

The purpose of the study was to prepare and evaluation chitosin-coated alginate/gelatin microspheres for sustained-release drug delivery system in vitro. The microspheres were prepared with an emulsification technique, characterized by scanning electron microscopy (SEM), Fourier transform infrared spectrophotometry (FT-IR), differential scanning calorimetry (DSC). The average particle size of the chitosan-coated alginate/gelatin microspheres was uniform. The results of FT-IR and DSC showed that the microspheres were formed by intermolecular cross-linkages between chitosan and gelatin. The results also implied that the microsphere were a practicable dosage form to increase drug loading ratio for the poorly water-soluble drugs by encapsulated with chitosan. In vitro release of the microsphere indicated that it had a satisfactory sustained-release behavior for the sustained-release drug delivery system.

A water-soluble methylated N-(4-N,N-dimethylaminocinnamyl) chitosan chloride as novel mucoadhesive polymeric nanocomplex platform for sustained-release drug delivery

2011 ◽  
Vol 83 (3) ◽  
pp. 1263-1273 ◽  
Author(s):  
Maleenart Petchsangsai ◽  
Warayuth Sajomsang ◽  
Pattarapond Gonil ◽  
Onanong Nuchuchua ◽  
Boonsong Sutapun ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Water Soluble ◽  
Release Drug

scholarly journals Recent advances in intraocular sustained-release drug delivery devices

2019 ◽  
Vol 24 (8) ◽  
pp. 1694-1700 ◽  
Author(s):  
Yiqi Cao ◽  
Karen E. Samy ◽  
Daniel A. Bernards ◽  
Tejal A. Desai
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Release Drug ◽  
Recent Advances ◽  
Drug Delivery Devices

Implementation of Quality by Design principles for the evolution of optimized sustained release drug delivery system

2021 ◽  
Vol 11 ◽  
Author(s):  
Lalit Singh ◽  
Vijay Sharma
Keyword(s):  
Mathematical Model ◽  
Drug Delivery ◽  
Sustained Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Form ◽  
Quality By Design ◽  
Design Principles ◽  
Release Drug

Aim: Aim of the present work is implementation of Quality by Design principles for the evolution of optimized sustained release drug delivery system Background: Quality by Design (QbD) approach refers to an advance approach to develop a optimized dosage form.QbD has become a vital modern scientific approach to develop a quality dosage form.In modern era of science researcher can develop a optimized dosage form with least effort, money and manpower. Objectives: Objective of research work wasthe successful development of optimized floating bioadhesive tablets of glipizide using floating-bioadhesive potential of cellulosic polymer and carbomersusing quality by design (QbD) approach. Method: Quality Target Product Profile (QTPP) of drug delivery system was defined as well as critical quality attributes (CQAs) were identified. A face centered central composite design (CCD) was utilized in assessing the impact of individual critical material attribute (CMA) like Hydro Propyl Methyl Cellulose K4M(HPMC K4M)and Carbopol 934P (CP 934P) and their interactions, using least experimentation. Formulations were developed and quantitative impact on CQAs was determined using mathematical model. The optimized formulation was obtained and characterized for in-vitro as well as in-vivo parameters. Results: A Fishikawa diagram and Failure Mode and Effect Analysis (FMEA) were performed to identify potential failure modes associated with the dosage form. The optimum formulation was embarked upon using mathematical model developed yielding desired CQAs followed for confirmation of data. Sustained release drug delivery system was successfully developed by using QbD approach. In-vivo X-ray imaging in rabbit and γ-scintigraphic study in manconfirmed the buoyant nature of the mucoadhesive floating tablet for 8 h in the upper gastrointestinal tract. Conclusion: Optimized formulation shows phenomenal floating, bioadhesive properties and drug release retardation characteristics, utilizing a mixture of cost-effective polymers Hence, QbD approach may be regarded as an important tool in development of floating bioadhesive CR dosage forms.

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