Nanocrystal-loaded liposome for targeted delivery of poorly water-soluble antitumor drugs with high drug loading and stability towards efficient cancer therapy

2021 ◽  
Vol 599 ◽  
pp. 120418 ◽  
Author(s):  
Huamin Liang ◽  
Fengming Zou ◽  
Qingwang Liu ◽  
Beilei Wang ◽  
Liyi Fu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Delivery ◽  
Drug Loading ◽  
Water Soluble ◽  
Antitumor Drugs ◽  
High Drug ◽  
Poorly Water Soluble ◽  
High Drug Loading

Co-delivery of dual chemo-drugs with precisely controlled, high drug loading polymeric micelles for synergistic anti-cancer therapy

2020 ◽  
Vol 8 (3) ◽  
pp. 949-959 ◽  
Author(s):  
Yuchen Wu ◽  
Shixian Lv ◽  
Yongjuan Li ◽  
Hua He ◽  
Yong Ji ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Polymeric Micelles ◽  
Drug Loading ◽  
High Drug ◽  
Delivery Strategy ◽  
Anti Cancer ◽  
High Drug Loading

The introduction of donor-receptor coordination between micelles and drug payloads provides a precise co-delivery strategy for two different chemo-drugs with high drug loading and ROS responsiveness.

Water soluble multiarm-polyethylene glycol–betulinic acid prodrugs: design, synthesis, and in vivo effectiveness

2014 ◽  
Vol 5 (19) ◽  
pp. 5775-5783 ◽  
Author(s):  
Lin Dai ◽  
Dan Li ◽  
Jing Cheng ◽  
Jing Liu ◽  
Li-Hong Deng ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Betulinic Acid ◽  
Water Solubility ◽  
Drug Loading ◽  
Water Soluble ◽  
Loading Capacity ◽  
Design Synthesis ◽  
High Drug ◽  
High Drug Loading

Multiarm-polyethylene glycol–betulinic acid prodrugs were prepared by using multiarm-polyethylene glycol linkers and betulinic acid, which exhibited high drug loading capacity, good water solubility, and excellent anticancer activity.

Uniform magnesium silicate hollow spheres as high drug-loading nanocarriers for cancer therapy with low systemic toxicity

2013 ◽  
Vol 42 (24) ◽  
pp. 8918 ◽  
Author(s):  
Baixiang Wang ◽  
Weiyan Meng ◽  
Ming Bi ◽  
Yuxin Ni ◽  
Qing Cai ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Loading ◽  
Hollow Spheres ◽  
Magnesium Silicate ◽  
Systemic Toxicity ◽  
High Drug ◽  
High Drug Loading

Dimeric camptothecin derived phospholipid assembled liposomes with high drug loading for cancer therapy

2018 ◽  
Vol 166 ◽  
pp. 235-244 ◽  
Author(s):  
Shuo Fang ◽  
Yongpeng Hou ◽  
Longbing Ling ◽  
Danquan Wang ◽  
Muhammad Ismail ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Loading ◽  
High Drug ◽  
High Drug Loading

scholarly journals Trisulfide bond–mediated doxorubicin dimeric prodrug nanoassemblies with high drug loading, high self-assembly stability, and high tumor selectivity

2020 ◽  
Vol 6 (45) ◽  
pp. eabc1725
Author(s):  
Yinxian Yang ◽  
Bingjun Sun ◽  
Shiyi Zuo ◽  
Ximu Li ◽  
Shuang Zhou ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Self Assembly ◽  
Rational Design ◽  
Colloidal Stability ◽  
Drug Loading ◽  
High Drug ◽  
Tumor Selectivity ◽  
Poor Stability ◽  
High Drug Loading

Rational design of nanoparticulate drug delivery systems (nano-DDS) for efficient cancer therapy is still a challenge, restricted by poor drug loading, poor stability, and poor tumor selectivity. Here, we report that simple insertion of a trisulfide bond can turn doxorubicin homodimeric prodrugs into self-assembled nanoparticles with three benefits: high drug loading (67.24%, w/w), high self-assembly stability, and high tumor selectivity. Compared with disulfide and thioether bonds, the trisulfide bond effectively promotes the self-assembly ability of doxorubicin homodimeric prodrugs, thereby improving the colloidal stability and in vivo fate of prodrug nanoassemblies. The trisulfide bond also shows higher glutathione sensitivity compared to the conventional disulfide bond, and this sensitivity enables efficient tumor-specific drug release. Therefore, trisulfide bond–bridged prodrug nanoassemblies exhibit high selective cytotoxicity on tumor cells compared with normal cells, notably reducing the systemic toxicity of doxorubicin. Our findings provide new insights into the design of advanced redox-sensitive nano-DDS for cancer therapy.

scholarly journals Iron-crosslinked Rososome with robust stability and high drug loading for synergistic cancer therapy

2020 ◽  
Author(s):  
Xiangdong Xue ◽  
Marina Ricci ◽  
Haijing Qu ◽  
Aaron Lindstrom ◽  
Dalin Zhang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Robust Stability ◽  
Drug Loading ◽  
High Drug ◽  
High Drug Loading
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