scholarly journals Towards a better mechanistic comprehension of drug permeation and absorption: Introducing the diffusion-partitioning interplay

2021 ◽  
Vol 608 ◽  
pp. 121116
Author(s):  
Martina M. Tzanova ◽  
Elizabeta Randelov ◽  
Paul C. Stein ◽  
Marianne Hiorth ◽  
Massimiliano Pio di Cagno
Keyword(s):  
2019 ◽  
Vol 3 (1) ◽  
pp. 64-74 ◽  
Author(s):  
Ravindra P. Birajdar ◽  
Sudha S. Patil ◽  
Vijaykumar V. Alange ◽  
Raghavendra V. Kulkarni

Objective: The study aimed to prepare electrically-triggered transdermal drug delivery systems (ETDS) using electrically responsive polyacrylamide-graft-gaur gum (PAAm-g-GaG) copolymer. Methods: The PAAm-g-GaG copolymer was synthesized by adopting free radical polymerization grafting method. This PAAm-g-GaG copolymer hydrogel acts as a drug reservoir and blend films of Guar Gum (GaG) and Polyvinyl Alcohol (PVA) were included as Rate Controlling Membranes (RCM) in the system. The PAAm-g-GaG copolymer was characterized by FTIR, neutralization equivalent values, thermogravimetric analysis and elemental analysis. Results: On the basis of results obtained, it is implicit that the drug permeation decreased with an increase in the concentration of glutaraldehyde and RCM thickness; while drug permeation rate was increased with increasing applied electric current strength from 2 to 8 mA. A two fold increase in flux values was observed with the application of DC electric current. An increase in drug permeation was witnessed under on condition of electric stimulus and permeation was decreased when electric stimulus was "off". The skin histopathology study confirmed the changes in skin structure when electrical stimulus was applied. Conclusion: The electrically-sensitive PAAm-g-GaG copolymer is a useful biomaterial for transdermal drug delivery application.


2009 ◽  
Vol 38 (2) ◽  
pp. 112-120 ◽  
Author(s):  
Ylenia Zambito ◽  
Stefano Fogli ◽  
Chiara Zaino ◽  
Fabio Stefanelli ◽  
Maria C. Breschi ◽  
...  

2015 ◽  
Vol 92 ◽  
pp. 14-26 ◽  
Author(s):  
Rita Monteiro Machado ◽  
Ana Palmeira-de-Oliveira ◽  
Carlos Gaspar ◽  
José Martinez-de-Oliveira ◽  
Rita Palmeira-de-Oliveira
Keyword(s):  

2018 ◽  
Vol 42 (17) ◽  
pp. 14179-14187
Author(s):  
Janisha Jayadevan ◽  
G. Unnikrishnan

Novel blend membranes from physico-chemically modified deproteinized natural rubber latex for drug release applications.


2014 ◽  
Vol 229 ◽  
pp. S144 ◽  
Author(s):  
Seyoum Ayehunie ◽  
Zacharey Stevens ◽  
Tim Landry ◽  
Mitchell Klausner ◽  
Patrik Hayden ◽  
...  

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