scholarly journals Tablet formulation development focusing on the functional behaviour of water uptake and swelling

2021 ◽  
pp. 100103
Author(s):  
Jan Lenz ◽  
Jan Henrik Finke ◽  
Heike Bunjes ◽  
Arno Kwade ◽  
Michael Juhnke
Keyword(s):  
Water Uptake ◽  
Tablet Formulation ◽  
Formulation Development

scholarly journals Formulation, Development, and Optimization of Anti- Hypertensive Nisoldipine Extended-Release Tablet Formulation

2020 ◽  
Vol 5 (03) ◽  
pp. 37-44
Author(s):  
Kukkadapu Pavan Kumar ◽  
Katta Sunand ◽  
Nerella Mounika ◽  
Mohammed Abdul Samad ◽  
A. Madhu Babu ◽  
...  
Keyword(s):  
Drug Release ◽  
Extended Release ◽  
Aqueous Solubility ◽  
Cellular Membrane ◽  
Tablet Formulation ◽  
Water Soluble ◽  
Matrix Tablets ◽  
Formulation Development ◽  
Release Tablet

A drug molecule has to be water-soluble to be readily delivered to the cellular membrane. Many drugs are waterinsoluble, which creates numerous problems in the development of dosage forms. Controlled drug delivery formulation releases the drug with controlled kinetics for days and months, reducing the frequency of dosing, minimizing side effects, and improving patient compliance. Nisoldipine is a calcium channel antagonist that is indicated for the treatment of hypertension with very poor aqueous solubility. Thus, there is a need to improve the rate of drug release. Hence, the study was carried out to design, formulate and evaluate sustained-release tablet formulation of nisoldipine. Nisoldipine controlled release matrix tablets were prepared by roll compaction method. Preformulation studies have confirmed the purity and compatibility of drug with excipients used in the formulation. Pre-compression studies have confirmed the stability of formulation blends for compression. All the prepared formulations were evaluated for various physical and compression parameters such as bulk and tapped density, hardness, friability, and in vitro drug release studies. The results of drug release from prepared compressed nisoldipine extended-release tablets were found to be within the desired range.

scholarly journals Multivariate Statistical Optimization of Tablet Formulations Incorporating High Doses of a Dry Herbal Extract

Pharmaceutics ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 79 ◽  
Author(s):  
Euichaul Oh ◽  
Uijung Kim ◽  
Beom-Jin Lee ◽  
Cheol Moon
Keyword(s):  
Tablet Formulation ◽  
Herbal Extract ◽  
Herbal Extracts ◽  
Formulation Development ◽  
Multivariate Statistical ◽  
Disintegration Time ◽  
Tablet Disintegration ◽  
Tablet Formulations ◽  
High Doses ◽  
Formulation Variables

The development of oral tablet formulation for herbal medicines has been restricted by large drug loadings and the poor physicochemical and mechanical properties of dry herbal extracts (DHEs). Herein, statistical experimental designs were applied to herbal tablet formulation development and optimization using Wuzi Yanzong dry extract (WYE). The tablet disintegration time and hardness were identified as the critical quality attributes (CQAs) of the product. The tablet formulation was designed to achieve a high drug loading (50% or higher of WYE), shorter tablet disintegration time (less than 30 minutes), and suitable hardness (6.0 to 7.5 kp). A D-optimal mixture design was used to evaluate the effects of excipients on CQAs to minimize the risk compression failure and improve the tabletability in formulations containing WYE at 50% and 65% by weight. A partial least squares model was used to elucidate the multivariate relationships between a large number of formulation variables and product CQAs, and determine the maximum possible WYE loading. From overlaid plots of the effects of formulation variables on CQAs, it was found that a maximum WYE loading of 67% in tablet formulation satisfied the acceptance criteria of CQAs. In conclusion, this study shows that multivariate statistical tools are useful for developing tablet formulations containing high doses of herbal extracts and establishing control strategies that ensure product quality.

scholarly journals Application of Sequential Design of Experiments to Develop Ibuprofen (400 mg) Tablets by Direct Compression

2017 ◽  
Vol 2 (1) ◽  
pp. 10
Author(s):  
Socorro Alpizar-Ramos ◽  
Mario González-de la Parra
Keyword(s):  
Design Of Experiments ◽  
Tablet Formulation ◽  
Sequential Design ◽  
Drug Substance ◽  
Direct Compression ◽  
Formulation Development ◽  
Efficient Strategy ◽  
The Poor

A strategy based on sequential design of experiments (screening, optimization and confirmation) was used to develop a tablet formulation of ibuprofen (400 mg) that is manufactured by direct compression. This formulation has a high content of ibuprofen (76%), in spite of the poor flowability of the drug substance. Sequential design of experiments proved to be an effective and efficient strategy in formulation development.

scholarly journals Development of fast dispersing tablets of nebivolol: experimental and computational approaches to study formulation characteristics

2014 ◽  
Vol 50 (4) ◽  
pp. 956-963
Author(s):  
Rajamma Abburu Jayaramu ◽  
Sateesha Shivally Boregowda ◽  
Addanki Rahul Deva Varma ◽  
Chandan Kalegowda
Keyword(s):  
Tablet Formulation ◽  
P Value ◽  
Formulation Development ◽  
Disintegration Time ◽  
Swelling Properties ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Surface Plot ◽  
Tablet Properties ◽  
Simplex Lattice

Formulation of FDT (fast dispersing tablets) of nebivolol was optimized and evaluated using simplex lattice design (SLD). The influence of type and concentration of three disintegrants viz.,Ac-Di-Sol, Primojel and Polyplasdone XL on hardness, friability and disintegration time of tablet was studied. Response surface plot and the polynomial equations were used to evaluate influence of polymer on the tablet properties. Results were statistically analyzed using ANOVA, and a p < 0.05 was considered statistically significant. Results reveal that fibrous integrity and optimal degree of substitution in Primojel and Ac-Di-Sol are mainly responsible for the hardness of the tablet. Use of Polyplasdone in higher percentage in tablet formulation may result in high friability. Increase in concentration of Ac-Di-Sol increases the disintegration time but increased concentration of Primojel in the tablet formulation decreases the disintegration time. This is also evident from model terms for disintegration time with a high 'F' value of 14.69 and 'p' value of 0.0031 (<0.05). The reason could be that Primojel has higher swelling properties and an optimum hydration capacity, which favors fast disintegration of a tablet. In conclusion, careful selection of disintegrant for FDT could improve their properties. Use of Simplex Lattice Design for formulation development could simplify the formulation process and reduce the production cost.

Water uptake by substituted amylose tablets: experimentation and numerical simulation

2009 ◽  
Vol 00 (00) ◽  
pp. 090904073309027-8
Author(s):  
H.W. Wang ◽  
S. Kyriacos ◽  
L. Cartilier
Keyword(s):  
Numerical Simulation ◽  
Water Uptake
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