Reduced Incidence of Second Head and Neck Cancers in Patients Treated With External Beam Radiotherapy for Squamous Cell Carcinoma of the Head and Neck: A SEER Database Analysis

2007 ◽  
Vol 69 (3) ◽  
pp. S56-S57
Author(s):  
K. Rusthoven ◽  
C. Chen ◽  
D. Raben ◽  
B. Kavanagh
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
External Beam Radiotherapy ◽  
Head And Neck Cancers ◽  
External Beam ◽  
Seer Database ◽  
Database Analysis

A PROSPECTIVE RANDOMIZED STUDY TO COMPARE THE CONCURRENT CHEMO-RADIATION VERSUS HYPO-FRACTIONATED CHEMO-RADIATION IN LOCALLY ADVANCED CERVICAL CANCER.

2021 ◽  
pp. 40-42
Author(s):  
Arpan Jana ◽  
Pabitra Das ◽  
Poulami Gupta ◽  
Phalguni Gupta
Keyword(s):  
Cervical Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
External Beam Radiotherapy ◽  
Locally Advanced ◽  
Intracavitary Brachytherapy ◽  
External Beam ◽  
Carcinoma Cervix ◽  
Advanced Carcinoma

Background: Concurrent chemo-radiation is the standard treatment worldwide for locally advanced squamous Cell carcinoma cervix. However, conventional chemo-radiotherapy is also associated with unacceptable local and systemic failure rates for locally advanced disease. Biologically squamous cell carcinoma of head- neck cancer and cervical cancer behaves quite similarly in response to radiotherapy. So, it can be expected that, altered fractionation can increase the local control in case of squamous cell carcinoma cervix than conventional radiotherapy. There is no randomised control trial for carcinoma cervix till date, which compares conventional chemo-radiation with hypo-fractionated chemo-radiation. Aims And Objectives: The present study was planned to compare local disease control and acute toxicity of conventional chemo-radiation with hypo-fractionated chemo-radiation in locally advanced carcinoma cervix. Materials And Methods: In Conventional Chemo-radiation Arm A patients (n=30) received external beam radiotherapy 50 Gy in 25 fractions in 5 weeks accompanied by weekly intravenous Cisplatin 40mg/m2 followed by intracavitary brachytherapy 7 Gy per fraction once in a week for 3 weeks. The second group of hypo-fractionated Arm B received external beam radiotherapy 45 Gy in 20 fractions in 4 weeks accompanied by weekly intravenous Cisplatin 40mg/m2 followed by intracavitary brachytherapy 9 Gy per fraction once in a week for 2 weeks. Results: Grade II diarrhea were seen more in Arm B 17 (56.66%) compare to Arm A 12(40%) and grade III diarrhea was seen 4 (3.33%) in Arm B and 2(6.66%) in Arm A. At 2 months and 6 months after completion of treatment Complete response were 25 (83.4%) in Arm A compare to 22 (73.3%) in Arm B and 20 (74.1%) in Arm A and 18 (72%) in Arm B respectively. Conclusion: Hypo-fractioned radiotherapy may be used as an alternate protocol for treatment of locally advanced carcinoma cervix with acceptable toxicities.

scholarly journals Effectiveness of planned surveillance for detecting second primary head and neck cancers after endoscopic resection of esophageal squamous cell carcinoma

2020 ◽  
Vol 50 (10) ◽  
pp. 1162-1167 ◽  
Author(s):  
Takeshi Shinozaki ◽  
Chikatoshi Katada ◽  
Kiyoto Shiga ◽  
Takahiro Asakage ◽  
Tetsuji Yokoyama ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Endoscopic Resection ◽  
Squamous Cell ◽  
Head And Neck Cancers ◽  
Transoral Surgery ◽  
Second Primary ◽  
Laryngeal Function

Abstract Background Second primary head and neck cancers after endoscopic resection of esophageal squamous cell carcinoma adversely affect patients’ outcomes and the quality of life; however, an adequate surveillance schedule remains unclear. Methods We analyzed 330 patients with early esophageal squamous cell carcinoma who underwent endoscopic resection and were registered in the multicenter cohort study to evaluate adequate surveillance for detection of second primary head and neck cancers. Gastrointestinal endoscopists examined the head and neck regions after 3–6 months of endoscopic resection for esophageal squamous cell carcinoma and subsequently every 6 months. An otolaryngologist also examined the head and neck regions at the time of endoscopic resection for esophageal squamous cell carcinoma and at 12 months intervals thereafter. Results During the median follow-up period of 49.4 months (1.3–81.2 months), 33 second primary head and neck cancers were newly detected in 20 patients (6%). The tumor site was as follows: 22 lesions in the hypopharynx, eight lesions in the oropharynx, two lesions in larynx and one lesion in the oral cavity. The 2-year cumulative incidence rate of second primary head and neck cancers was 3.7%. Among them, 17 patients with 29 lesions were treated by transoral surgery. One patient with two synchronous lesions was treated by radiotherapy. Two lesions in two patients were not detected after biopsy. All patients were cured with preserved laryngeal function. Conclusions Surveillance by gastrointestinal endoscopy every 6 months and surveillance by an otolaryngologist every 12 months could detect second primary head and neck cancers at an early stage, thereby facilitating minimally invasive treatment.

scholarly journals Recurrence of cancer cervix in patients treated by radical hysterectomy followed by adjuvant external beam radiotherapy

1970 ◽  
Vol 36 (2) ◽  
pp. 52-56 ◽  
Author(s):  
Fauzia Sobhan ◽  
Farzana Sobhan ◽  
Arif Sobhan
Keyword(s):  
Squamous Cell Carcinoma ◽  
Local Recurrence ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Radical Hysterectomy ◽  
External Beam Radiotherapy ◽  
Late Recurrence ◽  
Distant Recurrence ◽  
External Beam ◽  
Distant Failure

One hundred and twenty patients with FIGO stage Ib-IIa cervical cancer who had radical hysterectomy prior to January 2003 in different hospitals of Bangladesh and thereafter received external beam pelvic radiotherapy (RT) at National Institute of Cancer Research and Hospital, Dhaka were studied. Until December 2007, 50 (42%) patients developed recurrence. Thirty-four (70%) patients experienced local recurrence, 13 (26%) distant recurrence and 2 (4%) both local and distant recurrence. Of 15 patients with distant metastasis, 6 (40%) experienced it in extra-pelvic lymph nodes. The median time to recurrence was 19 months (range 6-120 months) for local failure, 33 months (range 12-108 months) for distant failure and 25 months (range 13-36 months) for those with both local and distant failure. Eighty percent recurrences occurred within 36 months. There was significant correlation between lymph node metastasis and recurrence. All 5 (100%) patients with adenocarcinoma who had positive nodes experienced local recurrence compared with 18 of 49 (37%) squamous cell carcinoma patients with positive nodes. Recurrence more than 5 years after treatment developed in 5 (4%) patients. Mentionable, 4 (80%) out of 5 patients with late recurrence had squamous cell carcinoma with negative pelvic nodes. DOI: 10.3329/bmrcb.v36i2.6987Bangladesh Med Res Counc Bull 2010; 36: 52-56

ETIOLOGICAL, CLINICAL AND PATHOLOGICAL PROGNOSTIC MARKERS IN HEAD AND NECK CANCERS TREATED WITH CONCURRENT CHEMO-RADIATION

2017 ◽  
Vol 2 (01) ◽  
Author(s):  
Ankur Yadav Sarkar ◽  
Piyush Kumar ◽  
Arvind Kumar Chauhan ◽  
Milan Jaiswal ◽  
D. P. Singh
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Surgical Techniques ◽  
Response Assessment ◽  
Concurrent Chemotherapy ◽  
Head And Neck Cancers ◽  
Related Factors

Introduction: Advanced squamous cell carcinoma of head and neck are usually treated with surgery and/or radiotherapy. Integration of chemotherapy also plays an important role for improving organ preservation. Various prognostic factors help in selecting the appropriate treatment regimen for the individual patient. The present study was conducted to identify the prognostic factors in head and neck cancers. Material and Methods: Previously untreated 33 patients of squamous cell carcinoma were selected. They were treated with concurrent chemotherapy and radiotherapy. The response assessment was analyzed in terms of various patient, tumor and treatment related factors. Statistical analysis was done using chi square test. Results: Etiological factors- tobacco and alcohol, non-vegetarean diet were associated with a poor outcome but were not statistically significant. Clinical factors- higher N-stage (p=0.04) and AJCC stage (p=0.03) were found to be significant predictors of poor prognosis while T-stage was not found significant, probably due to short follow-up. Patients receiving less than 5 cycles of concurrent chemotherapy had a significantly worse prognosis (p=0.04). Among the pathological factors that were studied, high mitotic index (Grade III or more) were associated with a significantly poorer prognosis (p=0.04). Conclusion: Many clinico pathological factors have been correlated with locoregional control in head and neck cancers. These can be used to individualize the treatment by different surgical techniques, various radiotherapy dose and fractionation schedules and chemotherapy protocols.

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