Local Control Dependence on Consecutive Versus Nonconsecutive Fractionation in Lung SBRT: A Propensity Score Matched Analysis

Abstract Single-session stereotactic radiosurgery (SSRS) is recognized as a safe and efficient treatment for meningioma. We aim to compare the long-term efficacy and safety of fractionated stereotactic radiotherapy (FSRT) with SSRS in the treatment of grade I meningioma. A total of 228 patients with 245 tumors treated with radiosurgery between March 2006 and June 2017were retrospectively evaluated. Of these, 147 (64.5%) patients were treated with SSRS. The remaining 81 patients (35.5%) were treated with a fractionated technique. Protocols to treat meningioma were classified as 12–16 Gy per fraction for SSRS and 7 Gy/fraction/day for three consecutive days to reach a total dose of 21 Gy for FSRT. In univariate and multivariate analyses, tumor volume was found to be associated with local control rate (hazard ratio = 4.98, p = 0.025). The difference in actuarial local control rate (LCR) between the SSRS and FSRT groups after propensity score matching (PSM) was not statistically significant during the 2-year (96.86% versus 100.00%, respectively; p = 0.175), 5-year (94.76% versus 97.56%, respectively; p = 0.373), and 10-year (74.40% versus 91.46%, respectively; p = 0.204) follow-up period. FSRT and SSRS were equally well-tolerated and effective for the treatment of intracranial benign meningioma during the10-year follow-up period.

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Local control of sphincter-preserving procedures and abdominoperineal resection for locally advanced low rectal cancer: Propensity score matched analysis

Annals of Gastroenterological Surgery ◽

10.1002/ags3.12032 ◽

2017 ◽

Vol 1 (3) ◽

pp. 199-207 ◽

Cited By ~ 4

Author(s):

Ryosuke Okamura ◽

Koya Hida ◽

Tomohiro Yamaguchi ◽

Tomonori Akagi ◽

Tsuyoshi Konishi ◽

...

Keyword(s):

Rectal Cancer ◽

Propensity Score ◽

Abdominoperineal Resection ◽

Local Control ◽

Locally Advanced ◽

Low Rectal Cancer

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Local control dependence on consecutive vs. nonconsecutive fractionation in lung stereotactic body radiation therapy

Radiotherapy and Oncology ◽

10.1016/j.radonc.2016.07.026 ◽

2016 ◽

Vol 121 (1) ◽

pp. 9-14 ◽

Cited By ~ 10

Author(s):

Fiori Alite ◽

Kyle Stang ◽

Neelam Balasubramanian ◽

William Adams ◽

Mohammad Parvez Shaikh ◽

...

Keyword(s):

Radiation Therapy ◽

Local Control ◽

Stereotactic Body Radiation Therapy ◽

Stereotactic Body Radiation ◽

Control Dependence

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EP-1369: High local control for lung SBRT of comorbid patients: prospective monocenter phase II STRIPE trial

Radiotherapy and Oncology ◽

10.1016/s0167-8140(18)31678-5 ◽

2018 ◽

Vol 127 ◽

pp. S747-S748

Author(s):

S. Adebahr ◽

U. Nestle ◽

K. Kaier ◽

T. Schimek-Jasch ◽

E. Gkika ◽

...

Keyword(s):

Phase Ii ◽

Local Control ◽

Lung Sbrt

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Does post-operative radiotherapy improve the treatment outcomes of intracranial hemangiopericytoma? A retrospective study

BMC Cancer ◽

10.1186/s12885-021-08594-x ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Jianbiao Xiao ◽

Lanwei Xu ◽

Yi Ding ◽

Wei Wang ◽

Fen Chen ◽

...

Keyword(s):

Propensity Score ◽

Local Control ◽

Proportional Hazards ◽

Intensity Modulated Radiotherapy ◽

Cox Proportional Hazards ◽

Matched Pair ◽

Propensity Score Method ◽

Chi Square ◽

Radiotherapy Group ◽

The Impact

Abstract Background Intracranial hemangiopericytoma is a rare disease and surgery is the mainstay treatment. Although postoperative adjuvant radiotherapy is often used, there are no reports comparing different radiotherapy techniques. The purpose of this study is to analyze the impact of post-operative radiotherapy and different radiotherapy technique on the results in patients with intracranial hemangiopericytoma (HPC). Methods We retrospectively reviewed 66 intracranial HPC patients treated between 1999 and 2019 including 29 with surgery followed by radiotherapy (11 with intensity-modulated radiotherapy (IMRT) and 18 with stereotactic radiosurgery (SRS)) and 37 with surgery alone. Chi-square test was used to compare the clinical characteristic between the groups. The Kaplan-Meier method was used to analyze overall survival (OS) and recurrence-free survival (RFS). Multivariate Cox proportional hazards models were used to examine prognostic factors of survival. We also underwent a matched-pair analysis by using the propensity score method. Results The crude local control rates were 58.6% in the surgery plus post-operative radiotherapy group (PORT) and 67.6% in the surgery alone group (p = 0.453). In the subgroup analysis of the PORT patients, local controls were 72.7% in the IMRT group and 50% in the SRS group (p = 0.228). The median OS in the PORT and surgery groups were 122 months and 98 months, respectively (p = 0.169). The median RFS was 96 months in the PORT group and 72 months in the surgery alone group (p = 0.714). Regarding radiotherapy technique, the median OS and RFS of the SRS group were not significantly different from those in the IMRT group (p = 0.256, 0.960). The median RFS were 112 and 72 months for pathology grade II and III patients, respectively (p = 0.001). Propensity score matching did not change the observed results. Conclusion In this retrospective analysis, PORT did not improve the local control rates nor the survivals. The local control rates after IMRT and SRS were similar even though the IMRT technique had a much higher biological dose compared with the SRS technique.

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Does Motion Management Technique for Lung SBRT Influence Local Control? A Single Institutional Experience Comparing Abdominal Compression to Breath-Hold Technique

Practical Radiation Oncology ◽

10.1016/j.prro.2020.10.008 ◽

2020 ◽

Author(s):

Senthilkumar Gandhidasan ◽

Neil M. Woody ◽

Kevin L. Stephans ◽

Gregory M.M. Videtic

Keyword(s):

Local Control ◽

Breath Hold ◽

Management Technique ◽

Abdominal Compression ◽

Motion Management ◽

Lung Sbrt ◽

Institutional Experience

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Prolonged Overall Treatment Time Negatively Affects the Outcomes of Stereotactic Body Radiotherapy for Early-Stage Non-Small Cell Lung Cancer: A Propensity Score-Weighted, Single-Center Analysis

10.21203/rs.3.rs-100183/v1 ◽

2020 ◽

Author(s):

TOSHIKI IKAWA ◽

Takahiro Tabuchi ◽

Koji Konishi ◽

Masahiro Morimoto ◽

Takero Hirata ◽

...

Keyword(s):

Overall Survival ◽

Propensity Score ◽

Local Control ◽

Treatment Time ◽

Early Stage ◽

Small Cell ◽

Tumor Control ◽

Small Cell Lung ◽

Overall Treatment Time ◽

Early Stage Nsclc

Abstract BackgroundPrevious studies have reported conflicting results for the effect of overall treatment time (OTT) on tumor control with stereotactic body radiotherapy (SBRT) for early-stage non-small cell lung cancer (NSCLC). To examine this effect, we conducted a propensity score-weighted, retrospective, observational study at a single institution.MethodsWe analyzed the data of 200 patients with early-stage NSCLC who underwent SBRT (48 Gy in 4 fractions) at our institution between January 2007 and October 2013. Patients were grouped into consecutive (OTT = 4–5 days, n = 116) or non-consecutive treatment groups (OTT = 6–10 days, n = 84). The outcomes of interest were local control and overall survival. The Cox regression model was used with propensity score and inverse probability of treatment weighting.ResultsThe median OTTs in the consecutive and non-consecutive groups were 4 and 6 days, respectively. The 5-year local control and overall survival rates in the consecutive group vs. non-consecutive group were 86.3% vs. 77.2% and 55.5% vs. 51.8%, respectively. After propensity score-weighting, consecutive SBRT was associated with positive local control (adjusted hazard ratio 0.30, 95% confidence interval 0.14–0.65; p=0.002) and overall survival benefits (adjusted hazard ratio 0.56, 95% confidence interval 0.34–0.91; p=0.019). ConclusionsProlonged OTT negatively affected the outcomes of patients with early-stage NSCLC treated with SBRT. To our knowledge, this is the first study to show that in patients with early-stage NSCLC treated with the same dose-fractionation regimen, consecutive SBRT has a more beneficial effect on tumor control than does non-consecutive SBRT.

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