scholarly journals Induction Chemotherapy Plus Simultaneous Modulated Accelerated Radiation Therapy in Non-operative Hypopharyngeal and Supraglottic Laryngeal Squamous Cell Carcinoma: Preliminary Results of a Prospective Phase 2 Study

2017 ◽  
Vol 99 (2) ◽  
pp. E326
Author(s):  
B.N. Cai ◽  
L. Ma ◽  
X.X. Zhang ◽  
B. Qu ◽  
X.K. Dai ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Radiation Therapy ◽  
Cell Carcinoma ◽  
Induction Chemotherapy ◽  
Squamous Cell ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Phase 2 ◽  
Phase 2 Study ◽  
Prospective Phase ◽  
Accelerated Radiation Therapy

scholarly journals Induction Chemotherapy Plus Simultaneous Modulated Accelerated Radiation Therapy in Non-operative Hypopharyngeal and Supraglottic Laryngeal Squamous Cell Carcinoma: Long-Term Outcome of a Prospective Phase 2 Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Boning Cai ◽  
Lingling Meng ◽  
Jingzi Mo ◽  
Shouping Xu ◽  
Baolin Qu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Radiation Therapy ◽  
Cell Carcinoma ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Phase 2 ◽  
Long Term Outcomes ◽  
Phase 2 Study ◽  
Prospective Phase ◽  
Accelerated Radiation Therapy

Background: To evaluate the toxicities and long-term outcomes of induction chemotherapy (ICT) plus simultaneous modulated accelerated radiation therapy (SMART) in non-operative hypopharyngeal and supraglottic laryngeal squamous cell carcinoma (SCCH/L).Materials and Methods: This was a prospective phase 2 study. Patients diagnosed with SCCH/L, aged from 18 to 75, staged from III to IVB in accordance with the AJCC 2010 criteria, and refusing surgery were eligible. The patients were treated with 2–3 cycles of docetaxel-cisplatin-based ICT and SMART combined with 2–3 cycles of cisplatin-based concurrent chemotherapy. The prescription dose to the primary tumor and metastatic nodes was 69 Gy in 30 fractions. Acute and late toxicities were assessed according to the established Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer (RTOG/EORTC) criteria, and long-term outcomes were analyzed.Results: Between February 2013 and June 2015, 55 newly diagnosed SCCH/L patients were enrolled. No grade 2 or worse acute xerostomia was noted. The incidences of grade 3 acute dermatitis, oral mucositis, and pharyngoesophagitis were 12.7, 3.6, and 12.7%, respectively. The median follow-up time was 48 months (range 5.5–74 months). The main late toxicity was hoarseness or sore throat, with an incidence of 32.7%. The 5-year functional larynx-preservation survival was 51.5%. The 3- and 5-year locoregional control and overall survival were 58.2, 51.5, 63.6, and 54.1%, respectively.Conclusions: The ICT plus SMART with a regimen of 69 Gy/30 F for the treatment of SCCH/L demonstrated acceptable severe toxicity, satisfactory long-term outcomes, and laryngeal function preservation.

Multicenter phase 2 study of induction chemotherapy with docetaxel and nedaplatin for oral squamous cell carcinoma

2009 ◽  
Vol 65 (3) ◽  
pp. 503-508 ◽  
Author(s):  
Hiroshi Kurita ◽  
Etsuhide Yamamoto ◽  
Shinichi Nozaki ◽  
Shigehito Wada ◽  
Isao Furuta ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Induction Chemotherapy ◽  
Squamous Cell ◽  
Phase 2 ◽  
Multicenter Phase ◽  
Phase 2 Study

Radiotherapy alone for human papillomavirus-related squamous cell carcinoma of the oropharynx: a single-arm, phase 2 study

2020 ◽  
Author(s):  
Norihiko Takemoto ◽  
Yuji Seo ◽  
Susumu Nakahara ◽  
Yasuo Yoshioka ◽  
Teruki Teshima ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Phase 2 ◽  
Phase 2 Study ◽  
Radiotherapy Alone
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