scholarly journals Statin Use and Major Adverse Cardiac Events among High Cardiac Risk Patients with Lung Cancer Receiving Radiotherapy

2020 ◽  
Vol 108 (3) ◽  
pp. S137-S138
Author(s):  
K.M. Atkins ◽  
D.S. Bitterman ◽  
T.L. Chaunzwa ◽  
N. Lamba ◽  
C.L. Williams ◽  
...  
2021 ◽  
pp. 0310057X2110246
Author(s):  
Yao Yao ◽  
Ashok Dharmalingam ◽  
Cyril Tang ◽  
Harrison Bell ◽  
Andrew DJ McKeown ◽  
...  

Clinicians assessing cardiac risk as part of a comprehensive consultation before surgery can use an expanding set of tools, including predictive risk calculators, cardiac stress tests and measuring serum natriuretic peptides. The optimal assessment strategy is unclear, with conflicting international guidelines. We investigated the prognostic accuracy of the Revised Cardiac Risk Index for risk stratification and cardiac outcomes in patients undergoing elective non-cardiac surgery in a contemporary Australian cohort. We audited the records for 1465 consecutive patients 45 years and older presenting to the perioperative clinic for elective non-cardiac surgery in our tertiary hospital. We calculated individual Revised Cardiac Risk Index scores and documented any use of preoperative cardiac tests. The primary outcome was any major adverse cardiac events within 30 days of surgery, including myocardial infarction, pulmonary oedema, complete heart block or cardiac death. Myocardial perfusion imaging was the most common preoperative stress test (4.2%, 61/1465). There was no routine investigation of natriuretic peptide levels for cardiac risk assessment before surgery. Major adverse cardiac events occurred in 1.3% (18/1366) of patients who had surgery. The Revised Cardiac Risk Index score had modest prognostic accuracy for major cardiac complications, area under receiver operator curve 0.73, 95% confidence interval 0.60 to 0.86. Stratifying major adverse cardiac events by the Revised Cardiac Risk Index scores 0, 1, 2 and 3 or greater corresponded to event rates of 0.6% (4/683), 0.8% (4/488), 4.1% (6/145) and 8.0% (4/50), respectively. The Revised Cardiac Risk Index had only modest predictive value in our single-centre experience. Patients with a revised cardiac risk index score of 2 or more had an elevated risk of early cardiac complications after elective non-cardiac surgery.


2019 ◽  
Vol 27 (3) ◽  
pp. 134-145
Author(s):  
Kok Siew Yean ◽  
Mahathar Bin Abd. Wahab ◽  
Mohd Idzwan Bin Zakaria

Background: Evaluation of chest pain patients in emergency departments to distinguish between high-risk patients who require admission and low-risk patients who can be managed as outpatients is a challenging task. Objective: The aim of this study was to evaluate the efficacy of Observation Ward Short Stay Evaluation Service for Chest Pain Protocol to identify and safely discharge low-risk patients with low incidence of major adverse cardiac events within 30 days. Methods: This was a single center prospective observational study, conducted from 1 March 2016 to 31 August 2016 at the Emergency and Trauma Department, Hospital Kuala Lumpur, Kuala Lumpur. Observation Ward Short Stay Evaluation Service for Chest Pain Protocol was used to evaluate patients presented with chest pain or angina equivalents. The components involved Thrombolysis in Myocardial Infarction (TIMI) score, serial electrocardiograms, high-sensitivity cardiac troponin T, and exercise treadmill test. Low-risk patients were patients with TIMI < 2, normal serial electrocardiogram, high-sensitivity cardiac troponin T ≤ 14 ng/L, and negative exercise treadmill test. If anyone of the components was not fulfilled patients were considered as high risk, and they were either admitted or referred to clinic for further intervention. Low-risk patients were allowed for discharged. All patients were followed-up in 30 days for any incidence of major adverse cardiac events. Results: Totally, 174 patients were studied. Observation Ward Short Stay Evaluation Service for Chest Pain Protocol managed to discharge 102 (58.6%) patients, and 84 (82.4%) of them underwent exercise treadmill test. About 46 (54.8%) patients had negative exercise treadmill test, whereas 38 (45.2%) patients had either positive or inconclusive exercise treadmill test, and they were referred to physician clinic for further cardiac assessment. None of the patients with negative exercise treadmill test developed major adverse cardiac events in 30 days. The sensitivity and the negative predictive value (NPV) of Observation Ward Short Stay Evaluation Service for Chest Pain Protocol were both 100%. Conclusion: Observation Ward Short Stay Evaluation Service for Chest Pain Protocol can be applied in emergency departments to identify and safely discharge patients with low risk of major adverse cardiac events in 30 days.


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