Serum vitamin D level in Egyptian children with Familial Mediterranean fever

Abstract Background Familial Mediterranean fever (FMF) is autosomal recessive chronic disease represents by recurring attacks of polyserositis, fever, and joint pain. Vitamin D deficiency in FMF children has been recently mentioned in literature and linked to delayed physical growth. Osteoporosis in FMF patients can be linked to low levels of vitamin D, too. Osteoprotegerin (OPG) might be used as an indicator for osteoporosis. Therefore, this work aimed to investigate the impact of vitamin D administration on clinical status, BMI, and bone mineral density represented by alterations in the OPG serum levels in a group of Egyptian children with FMF. This was a prospective longitudinal study carried out on 33 children, aged 4–16 years, with FMF cases. Patients were on colchicine 0.5–2 mg/day and received vitamin D3 oral drops 2800 IU/ml; each drop contains 100 IU in a dose of 600 IU/day for 6 months. The effect of vitamin D administration was evaluated clinically, anthropometrically and by assessment of serum vitamin D and osteoprotegerin at baseline and 6 months later. Results Serum vitamin D levels were below the normal range before intervention and showed significant improvement (p < 0.001) 6 months after intervention. Significant increase in both BMI Z scores (p < 0.05) and OPG serum levels and improvement in the clinical status as illustrated by significant decrease in the number of cases with fever, arthritis, and abdominal pain and significant decrease in the frequency and duration of the attacks (p < 0.001). Conclusion Our results intensely indicate that vitamin D supplementation improved the clinical condition, BMI, and bone mineral density in children with FMF.

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Serum vitamin d levels during activation and remission periods of patients with juvenile idiopathic arthritis and familial mediterranean fever

The Turkish Journal of Pediatrics ◽

10.24953/turkjped.2016.02.001 ◽

2016 ◽

Vol 58 (2) ◽

pp. 125 ◽

Cited By ~ 2

Author(s):

Aydilek Dağdeviren-Çakır ◽

Ahmet Arvas ◽

Kenan Barut ◽

Emel Gür ◽

Özgür Kasapçopur

Keyword(s):

Vitamin D ◽

Juvenile Idiopathic Arthritis ◽

Familial Mediterranean Fever ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Mediterranean Fever

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AB1006 Serum Vitamin D Levels During Activation and Remission Periods of Patients with Juvenile Idiopathic Arthritis and Familial Mediterranean Fever

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2015-eular.6102 ◽

2015 ◽

Vol 74 (Suppl 2) ◽

pp. 1235.2-1235

Author(s):

A. Dagdeviren ◽

A. Arvas ◽

K. Barut ◽

E. Gur ◽

O. Kasapcopur

Keyword(s):

Vitamin D ◽

Juvenile Idiopathic Arthritis ◽

Familial Mediterranean Fever ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Mediterranean Fever

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Assessment of 25 Hydroxy Cholecalceferol Level in Autistic Children; is there a role for it in Treatment of Autism Spectrum Disorder?

QJM ◽

10.1093/qjmed/hcab113.039 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Martina Alfred Youssef Nakhla ◽

Eman Ahmed Zaky ◽

Enas Samir Nabeh ◽

Asmaa Wafeeq Abd El Aziz

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Autism Spectrum ◽

Laboratory Evaluation ◽

Control Group ◽

Autistic Children ◽

Serum Vitamin D ◽

Group I ◽

Egyptian Children ◽

Therapeutic Doses

Abstract Background Autism is a group of neurodevelopmental disabilities with various genetic and environmental risk factors. Vitamin D is an important neurosteroid hormone which can affect brain development and function, but research on its use in treating autism has been limited. Objectives The current study aimed at assessing the level of 25 OH vit D3level in a group of autistic infants and children compared to controls and correlating it with the severity of autistic manifestations and evaluation of the role of therapeutic doses of vitamin D on the severity of autistic manifestations. Methodology Thirty autistic Egyptian children (group I) and 30 clinically healthy age and sex matched controls were enrolled (group II). Therapeutic doses of vitamin D were given for autistic children who showed insufficient levels of 25 OH cholecalceferol for a period of 4-6 weeks followed by maintenance doses for another 6 weeks. Psychometric and laboratory evaluation for this group was done thrice: at the onset of study, at 6 week after enrollment in the study, and at 12 weeks after that enrollment. Results Serum vitamin D level was substantially reduced in patients with ASD in comparison to control group, and on the other hand, 25 (OH) vitamin D level was significantly negatively correlated with ATEC score and Total CARS score. Autistic children who received vitamin D3 treatment had significant improvement of CARS and ATEC scores. Conclusion vitamin D supplementation significantly improved the outcome of enrolled autistic children. It is recommended to follow up our studied sample to check the consolidation of improvement for how long it will be needed.

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Decreased serum vitamin B12 and vitamin D levels affect sleep quality in children with familial Mediterranean fever

Rheumatology International ◽

10.1007/s00296-017-3883-2 ◽

2017 ◽

Vol 38 (1) ◽

pp. 83-87 ◽

Cited By ~ 3

Author(s):

Rabia Miray Kisla Ekinci ◽

Sibel Balci ◽

Mahir Serbes ◽

Dilek Dogruel ◽

Derya Ufuk Altintas ◽

...

Keyword(s):

Vitamin D ◽

Familial Mediterranean Fever ◽

Sleep Quality ◽

Vitamin B12 ◽

Serum Vitamin ◽

Vitamin D Levels ◽

Mediterranean Fever

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Influence of Supplementary Vitamin D on the Prognostic Pathway of Type1 Diabetes Among Children

Biomedical & Pharmacology Journal ◽

10.13005/bpj/2126 ◽

2021 ◽

Vol 14 (1) ◽

pp. 303-309

Author(s):

Mostafa Hassan Ragab ◽

Eman Monir Sherif ◽

Nadia Badawy Abd- El Gawad ◽

Safaa Mohamed Elserougy ◽

Eman Essam Shaban ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Vitamin D Supplementation ◽

Oral Vitamin ◽

Intake Assessment ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Egyptian Children ◽

The Impact

Diabetes is one of the commonest chronic diseases worldwide. Vitamin D deficiency showed to be increasing, and have a potential role in autoimmune diseases among which in type 1 diabetes. The aim The aim of the study was to assess the impact of oral vitamin D supplementation on blood glucose (HbA1C) in T1DM patients and to find out the role of vitamin D as a biomarker for follow of T1DM patients compared to HbA1C. Subjects and methods: A randomized interventional clinical study was designed. The study enrolled 60 children patients with T1DM. Only 45 children continued to the end of study. Initial (pre-intake) assessment included history taking, clinical examination, and measurement of serum 25-OH vitamin D3 and serum HbA1C. These children received oral vitamin D supplements for 3 months then post-intake assessment were done again. Results: The study showed that serum vitamin D was deficient among Egyptian children and adolescents with T1DM (mean 11.4±3.4 ng/ml). , 53.33% of the patients had vitamin D deficiency with a 35.6% had insufficiency and 11.11% were VD sufficient. Patients received oral vitamin D supplementation for 3 months after which marked improvement in the levels of serum vitamin D levels and HA1C, 87.5% and 86.5% respectively.

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Decreased vitamin D levels in children with primary mono-symptomatic nocturnal enuresis

Egyptian Journal of Medical Human Genetics ◽

10.1186/s43042-021-00191-8 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Farida M. El-Baz ◽

Marian G. R. Abdelsayed ◽

Aziza S. Abdel-Hafeez ◽

Reham I. Abdelmageed

Keyword(s):

Vitamin D ◽

Nocturnal Enuresis ◽

Serum Vitamin ◽

Study Groups ◽

Healthy Children ◽

Hydroxyvitamin D ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Egyptian Children ◽

25 Hydroxyvitamin D

Abstract Background Nocturnal enuresis (NE) is a common voiding problem in pediatric populations. Relatively, few studies have investigated the 25-Hydroxyvitamin D and NE associations in children, which may open up a new research area on the effect of vitamin D as nutritional therapy in the treatment of NE. The aim of this study was to determine the level of 25-hydroxyl vitamin D among children and adolescents with nocturnal enuresis in comparison to non-enuretic Egyptian children. Results Fifty children (24 females, 26 males) who presented with primary mono-symptomatic nocturnal enuresis (PMNE) and 50 healthy children (23 females, 27 males) were recruited in this study. A structured questionnaire focusing on demographic, socioeconomic, and frequency of bed-wetting were collected, and vitamin D serum levels were assessed in all children. In the NE group, the mean value of serum vitamin D levels was lower than the control (19.0 ± 6.5 versus 23.89 ± 4.19; P < 0.0001). Serum 25-hydroxyvitamin D levels were abnormal (< 20 ng/mL) in 46% of children with NE and 16% of controls (P < 0.001). The higher bed-wetting frequencies were associated with lower levels of 25(OH) D (Every night: 7.0 ± 1.4, 3–5 time/week: 11.2 ± 1.7, 1–3 times/week: 17.6 ± 3.7, < 2times/week: 22.4 ± 2.9, Once/6 month: 24.1 ± 4.3 (ng/ml), P < 0.001). Conclusion A difference in serum 25-hydroxyvitamin D levels was found between the two study groups. There is a need for more studies to explain vitamin D deficiency in larger series so that this test can be used in regular enuretic child investigations.

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