scholarly journals Comparison of machine learning methods for the classification of cardiovascular disease

2021 ◽  
pp. 100606
Author(s):  
Rachael Hagan ◽  
Charles J. Gillan ◽  
Fiona Mallett
Keyword(s):  
Machine Learning ◽  
Cardiovascular Disease ◽  
Learning Methods ◽  
Machine Learning Methods

Machine Learning methods for micro-FTIR imaging classification of human skin tumors

2021 ◽  
Author(s):  
Matheus del Valle ◽  
Kleber Stancari ◽  
Pedro Arthur Augusto de Castro ◽  
Moises Oliveira dos Santos ◽  
Denise Maria Zezell
Keyword(s):  
Machine Learning ◽  
Human Skin ◽  
Skin Tumors ◽  
Learning Methods ◽  
Ftir Imaging ◽  
Machine Learning Methods ◽  
Imaging Classification

scholarly journals Classification of HIV-1 Protease Inhibitors by Machine Learning Methods

ACS Omega ◽  
2018 ◽  
Vol 3 (11) ◽  
pp. 15837-15849 ◽  
Author(s):  
Yang Li ◽  
Yujia Tian ◽  
Zijian Qin ◽  
Aixia Yan
Keyword(s):  
Machine Learning ◽  
Protease Inhibitors ◽  
Learning Methods ◽  
Machine Learning Methods ◽  
Hiv 1

scholarly journals Seeing It All: Evaluating Supervised Machine Learning Methods for the Classification of Diverse Otariid Behaviours

PLoS ONE ◽  
2016 ◽  
Vol 11 (12) ◽  
pp. e0166898 ◽  
Author(s):  
Monique A. Ladds ◽  
Adam P. Thompson ◽  
David J. Slip ◽  
David P. Hocking ◽  
Robert G. Harcourt
Keyword(s):  
Machine Learning ◽  
Supervised Machine Learning ◽  
Learning Methods ◽  
Machine Learning Methods

scholarly journals Accurate Prediction of Coronary Heart Disease for Patients With Hypertension From Electronic Health Records With Big Data and Machine-Learning Methods: Model Development and Performance Evaluation (Preprint)

2019 ◽  
Author(s):  
Zhenzhen Du ◽  
Yujie Yang ◽  
Jing Zheng ◽  
Qi Li ◽  
Denan Lin ◽  
...  
Keyword(s):  
Machine Learning ◽  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Big Data ◽  
Heart Disease ◽  
Large Population ◽  
High Accuracy ◽  
Learning Methods ◽  
Health Records ◽  
Machine Learning Methods

BACKGROUND Predictions of cardiovascular disease risks based on health records have long attracted broad research interests. Despite extensive efforts, the prediction accuracy has remained unsatisfactory. This raises the question as to whether the data insufficiency, statistical and machine-learning methods, or intrinsic noise have hindered the performance of previous approaches, and how these issues can be alleviated. OBJECTIVE Based on a large population of patients with hypertension in Shenzhen, China, we aimed to establish a high-precision coronary heart disease (CHD) prediction model through big data and machine-learning METHODS Data from a large cohort of 42,676 patients with hypertension, including 20,156 patients with CHD onset, were investigated from electronic health records (EHRs) 1-3 years prior to CHD onset (for CHD-positive cases) or during a disease-free follow-up period of more than 3 years (for CHD-negative cases). The population was divided evenly into independent training and test datasets. Various machine-learning methods were adopted on the training set to achieve high-accuracy prediction models and the results were compared with traditional statistical methods and well-known risk scales. Comparison analyses were performed to investigate the effects of training sample size, factor sets, and modeling approaches on the prediction performance. RESULTS An ensemble method, XGBoost, achieved high accuracy in predicting 3-year CHD onset for the independent test dataset with an area under the receiver operating characteristic curve (AUC) value of 0.943. Comparison analysis showed that nonlinear models (K-nearest neighbor AUC 0.908, random forest AUC 0.938) outperform linear models (logistic regression AUC 0.865) on the same datasets, and machine-learning methods significantly surpassed traditional risk scales or fixed models (eg, Framingham cardiovascular disease risk models). Further analyses revealed that using time-dependent features obtained from multiple records, including both statistical variables and changing-trend variables, helped to improve the performance compared to using only static features. Subpopulation analysis showed that the impact of feature design had a more significant effect on model accuracy than the population size. Marginal effect analysis showed that both traditional and EHR factors exhibited highly nonlinear characteristics with respect to the risk scores. CONCLUSIONS We demonstrated that accurate risk prediction of CHD from EHRs is possible given a sufficiently large population of training data. Sophisticated machine-learning methods played an important role in tackling the heterogeneity and nonlinear nature of disease prediction. Moreover, accumulated EHR data over multiple time points provided additional features that were valuable for risk prediction. Our study highlights the importance of accumulating big data from EHRs for accurate disease predictions.

Classification of beta‐site amyloid precursor protein cleaving enzyme 1 inhibitors by using machine learning methods

2021 ◽  
Author(s):  
Ravi Singh ◽  
Ankit Ganeshpurkar ◽  
Powsali Ghosh ◽  
Ankit Vyankatrao Pokle ◽  
Devendra Kumar ◽  
...  
Keyword(s):  
Machine Learning ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Learning Methods ◽  
Machine Learning Methods

scholarly journals Optimizing automatic morphological classification of galaxies with machine learning and deep learning using Dark Energy Survey imaging

2020 ◽  
Vol 493 (3) ◽  
pp. 4209-4228 ◽  
Author(s):  
Ting-Yun Cheng ◽  
Christopher J Conselice ◽  
Alfonso Aragón-Salamanca ◽  
Nan Li ◽  
Asa F L Bluck ◽  
...  
Keyword(s):  
Machine Learning ◽  
Imaging Data ◽  
Morphological Classification ◽  
Learning Methods ◽  
Visual Classification ◽  
Machine Learning Methods ◽  
Dark Energy Survey ◽  
Galaxy Classification ◽  
Energy Survey

ABSTRACT There are several supervised machine learning methods used for the application of automated morphological classification of galaxies; however, there has not yet been a clear comparison of these different methods using imaging data, or an investigation for maximizing their effectiveness. We carry out a comparison between several common machine learning methods for galaxy classification [Convolutional Neural Network (CNN), K-nearest neighbour, logistic regression, Support Vector Machine, Random Forest, and Neural Networks] by using Dark Energy Survey (DES) data combined with visual classifications from the Galaxy Zoo 1 project (GZ1). Our goal is to determine the optimal machine learning methods when using imaging data for galaxy classification. We show that CNN is the most successful method of these ten methods in our study. Using a sample of ∼2800 galaxies with visual classification from GZ1, we reach an accuracy of ∼0.99 for the morphological classification of ellipticals and spirals. The further investigation of the galaxies that have a different ML and visual classification but with high predicted probabilities in our CNN usually reveals the incorrect classification provided by GZ1. We further find the galaxies having a low probability of being either spirals or ellipticals are visually lenticulars (S0), demonstrating that supervised learning is able to rediscover that this class of galaxy is distinct from both ellipticals and spirals. We confirm that ∼2.5 per cent galaxies are misclassified by GZ1 in our study. After correcting these galaxies’ labels, we improve our CNN performance to an average accuracy of over 0.99 (accuracy of 0.994 is our best result).

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