Background:
Baseline social support is associated with outcomes after AMI. However, little is known about changes in social support during the early AMI recovery period and whether changes influence outcomes over the first year.
Methods:
Using data from 1951 AMI patients enrolled in the 19-center PREMIER study, we longitudinally examined whether changes in social support between baseline (index hospitalization) and 1 month post-AMI were associated with health status and depressive symptom outcomes. Using 5 items from the ENRICHD Social Support Inventory, we categorized patients into low (score <=18) and high (score >18) support and examined changes between these categories during the first month of recovery. Health status and depressive symptoms were assessed at baseline, 6, and 12 months using the Seattle Angina Questionnaire (SAQ), Short Form-12 (SF-12), and the Patient Health Questionnaire-9 (PHQ-9). Associations were evaluated using hierarchical repeated-measures regression, adjusting for site, baseline health status, depressive symptoms, and other sociodemographic and clinical factors.
Results:
During the first month of recovery, 5.6% of patients had persistently low support, 6.4% had worsened support, 8.1% had improved support, and 80.0% had persistently high support. In risk-adjusted analyses, patients with persistently low or worsened support (versus those with persistently high support) had greater risk of angina, worse SAQ quality of life (QOL), worse SF-12 mental component summary (MCS), and more PHQ-9 depressive symptoms (
table
). Patients with improved support had outcomes consistent with those of patients with persistently high support (
table
). Similarly, patients with worsened support had outcomes comparable to patients with persistently low support (p>0.50 for all comparisons).
Conclusion:
Changes in social support within the early recovery period are not uncommon and are important for predicting patient-centered outcomes.
Outcome
Social Support Status at 1 Month
Persistently Low
Worsened
Improved
Persistently High
SAQ Angina
*
1.39 (1.09, 1.78)
1.46 (1.08, 1.97)
1.13 (0.89, 1.43)
reference
SAQ QoL
†
-7.63 (-10.96, -4.30)
-7.44 (-10.54, -4.34)
-0.85 (-3.49, 1.80)
reference
SF-12 PCS
†
-0.14 (-2.20, 1.91)
-0.20 (-2.14, 1.73)
-0.44 (-2.07, 1.18)
reference
SF-12 MCS
†
-5.63 (-7.33, -3.92)
-4.82 (-6.42, -3.22)
-1.54 (-2.88, -0.20)
reference
PHQ-9
†
2.29 (1.51, 3.06)
1.94 (1.22, 2.66)
0.81 (0.19, 1.43)
reference
*
Estimates correspond to relative risks (95% confidence intervals) of any angina (SAQ Angina Score <100).
†
Estimates correspond to beta values (95% confidence intervals).