A novel target anti-interleukin-13 receptor subunit alpha-2 monoclonal antibody inhibits tumor growth and metastasis in lung cancer

2020 ◽  
pp. 107155
Author(s):  
Ghulam Raza ◽  
Fakhar-un-Nisa Yunus ◽  
Hitesh Bhagavanbhai Mangukiya ◽  
Siva Bharath Merugu ◽  
Dhahiri Saidi Mashausi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Monoclonal Antibody ◽  
Tumor Growth ◽  
Receptor Subunit ◽  
Interleukin 13 ◽  
Tumor Growth And Metastasis ◽  
Novel Target

scholarly journals Systemic Platelet-activating Factor Receptor Activation Augments Experimental Lung Tumor Growth and Metastasis

2014 ◽  
Vol 7 ◽  
pp. CGM.S14501 ◽  
Author(s):  
Patrick C. Hackler ◽  
Sarah Reuss ◽  
Raymond L. Konger ◽  
Jeffrey B. Travers ◽  
Ravi P. Sahu
Keyword(s):  
Lung Cancer ◽  
Tumor Growth ◽  
Cancer Progression ◽  
Lung Tumor ◽  
Platelet Activating Factor ◽  
Receptor Activation ◽  
Dependent Manner ◽  
Melanoma Tumor ◽  
Tumor Growth And Metastasis ◽  
The Impact

Pro-oxidative stressors including cigarette smoke (CS) generate novel lipids with platelet-activated factor-receptor (PAF-R) agonistic activity mediate systemic immunosuppression, one of the most recognized events in promoting carcinogenesis. Our previous studies have established that these oxidized-PAF-R-agonists augment murine B16F10 melanoma tumor growth in a PAF-R-dependent manner because of its effects on host immunity. As CS generates PAF-R agonists, the current studies sought to determine the impact of PAF-R agonists on lung cancer growth and metastasis. Using the murine Lewis Lung Carcinoma (LLC1) model, we demonstrate that treatment of C57BL/6 mice with a PAF-R agonist augments tumor growth and lung metastasis in a PAF-R-dependent manner as these findings were not seen in PAF-R-deficient mice. Importantly, this effect was because of host rather than tumor cells PAF-R dependent as LLC1 cells do not express functional PAF-R. These findings indicate that experimental lung cancer progression can be modulated by the PAF system.

scholarly journals Role of Exosomal Noncoding RNAs in Lung Carcinogenesis

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Tao Sun ◽  
Bill Kalionis ◽  
Guoying Lv ◽  
Shijin Xia ◽  
Wen Gao
Keyword(s):  
Lung Cancer ◽  
Tumor Growth ◽  
Cancer Biology ◽  
Noncoding Rnas ◽  
Membrane Vesicles ◽  
Body Fluids ◽  
Cancer Death ◽  
Lung Carcinogenesis ◽  
Tumor Growth And Metastasis

Lung cancer is the major cause of cancer death worldwide. Novel, recently discovered classes of noncoding RNAs (ncRNAs) have diverse functional and regulatory activities and increasing evidence suggests crucial roles for deregulated ncRNAs in the onset and progression of cancer, including lung cancer. Exosomes are small extracellular membrane vesicles of endocytic origin that are released by many cells and are found in most body fluids. Tumor-derived exosomes mediate tumorigenesis by facilitating tumor growth and metastasis. MicroRNAs (miRNAs) are a subclass of ncRNAs that are present in exosomes. miRNAs are taken up by neighboring or distant cells and modulate various functions of recipient cells. Here, we review exosome-derived ncRNAs with a focus on miRNAs and their role in lung cancer biology.

Neutralizing Monoclonal Antibody to Periostin Inhibits Ovarian Tumor Growth and Metastasis

2011 ◽  
Vol 10 (8) ◽  
pp. 1500-1508 ◽  
Author(s):  
Min Zhu ◽  
Romaine E. Saxton ◽  
Lillian Ramos ◽  
David D. Chang ◽  
Beth Y. Karlan ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Tumor Growth ◽  
Ovarian Tumor ◽  
Neutralizing Monoclonal Antibody ◽  
Tumor Growth And Metastasis
Sign in / Sign up

Export Citation Format

Share Document