Spatiotemporal expression pattern of neuroepithelial stem cell marker nestin suggests a role in dermal homeostasis, neovasculogenesis, and tumor stroma development: A study on embryonic and adult human skin

2010 ◽  
Vol 63 (1) ◽  
pp. 93-113 ◽  
Author(s):  
Klaus Sellheyer ◽  
Dieter Krahl
Keyword(s):  
Stem Cell ◽  
Expression Pattern ◽  
Human Skin ◽  
Tumor Stroma ◽  
Stem Cell Marker ◽  
Cell Marker ◽  
Adult Human ◽  
Spatiotemporal Expression ◽  
Adult Human Skin

scholarly journals Pluripotency-associated stem cell marker expression in proliferative cell cultures derived from adult human pancreas

2011 ◽  
Vol 211 (2) ◽  
pp. 169-176 ◽  
Author(s):  
Michael G White ◽  
Hussain R Al-Turaifi ◽  
Graham N Holliman ◽  
Ali Aldibbiat ◽  
Aiman Mahmoud ◽  
...  
Keyword(s):  
Stem Cell ◽  
Western Blot ◽  
Gradient Centrifugation ◽  
Stem Cell Marker ◽  
Stem Cell Markers ◽  
Human Pancreas ◽  
Cell Marker ◽  
Β Cells ◽  
Pancreatic Cell ◽  
Adult Human

The source of new β-cells in adult human pancreas remains incompletely elucidated with recent studies on rodents providing evidence for neogenesis from progenitor cells in addition to self-replication. The aim of this study was to investigate the expression of pluripotency-associated stem cell markers in proliferative cultures derived from adult human pancreas. Human pancreatic tissue was obtained from deceased donors following ethical approval and relative consent. Islet-enriched fraction was separated from the retrieved organ by digestion and density gradient centrifugation. Dissociated cells were seeded in adherent culture forming proliferative ‘islet survivor cells’ (ISCs). These were characterised at fifth passage by RT-PCR, immunofluorescence staining, FACS, western blot and transfection studies with an OCT4 promoter-driven reporter. Nuclear expression of the pluripotency-associated stem cell marker complex OCT4/SOX2/NANOG was confirmed in ISCs. The phenotype constituted ∼8% of the overall population. OCT4 biosynthesis was confirmed by western blot and activation of an exogenous OCT4 promoter. Co-expression of pluripotency-associated markers has been confirmed in proliferative primary cells derived from adult human pancreas. Further studies are required to elucidate whether these cells possess functional stem cell characteristics and assess potential for differentiation into pancreatic cell lineages including new β-cells.

Prominin-1/CD133, a neural and hematopoietic stem cell marker, is expressed in adult human differentiated cells and certain types of kidney cancer

2004 ◽  
Vol 319 (1) ◽  
pp. 15-26 ◽  
Author(s):  
Mareike Florek ◽  
Michael Haase ◽  
Anne-Marie Marzesco ◽  
Daniel Freund ◽  
Gerhard Ehninger ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Kidney Cancer ◽  
Stem Cell Marker ◽  
Cell Marker ◽  
Hematopoietic Stem ◽  
Adult Human ◽  
Differentiated Cells

Stem Cell Marker Prominin-1/AC133 Is Expressed in Duct Cells of the Adult Human Pancreas

Pancreas ◽  
2008 ◽  
Vol 36 (1) ◽  
pp. e1-e6 ◽  
Author(s):  
Jessy Lardon ◽  
Denis Corbeil ◽  
Wieland B. Huttner ◽  
Zhidong Ling ◽  
Luc Bouwens
Keyword(s):  
Stem Cell ◽  
Stem Cell Marker ◽  
Human Pancreas ◽  
Cell Marker ◽  
Adult Human ◽  
Duct Cells

KLF4 inhibition promotes the expansion of keratinocyte precursors from adult human skin and of embryonic-stem-cell-derived keratinocytes

2019 ◽  
Vol 3 (12) ◽  
pp. 985-997 ◽  
Author(s):  
Nicolas O. Fortunel ◽  
Loubna Chadli ◽  
Julien Coutier ◽  
Gilles Lemaître ◽  
Frédéric Auvré ◽  
...  
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Human Skin ◽  
Embryonic Stem ◽  
Adult Human ◽  
Adult Human Skin

scholarly journals Association of stem cell marker expression pattern and survival in human biliary tract cancer

2012 ◽  
Vol 41 (2) ◽  
pp. 511-522 ◽  
Author(s):  
RALF KEMMERLING ◽  
BEATE ALINGER ◽  
OTTO DIETZE ◽  
HANS-CHRISTIAN BÖSMÜLLER ◽  
MATTHIAS OCKER ◽  
...  
Keyword(s):  
Stem Cell ◽  
Expression Pattern ◽  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Stem Cell Marker ◽  
Cell Marker ◽  
Tract Cancer ◽  
Marker Expression

scholarly journals Expression Pattern of the Cancer Stem Cell Marker “Nestin” in Leukoplakia and Oral Squamous Cell Carcinoma

2019 ◽  
Vol 10 (4) ◽  
pp. e0024
Author(s):  
Kushbu Narender Singh ◽  
Madhavan Nirmal Ramadas ◽  
Veeravarmal Veeran ◽  
Murali Radhakrishnan Naidu ◽  
Thamarai Selvi Dhanaraj ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Oral Squamous Cell Carcinoma ◽  
Cancer Stem Cell ◽  
Cell Carcinoma ◽  
Expression Pattern ◽  
Squamous Cell ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker

scholarly journals Newer Insights Into Premeiotic Development of Germ Cells in Adult Human Testis Using Oct-4 as a Stem Cell Marker

2010 ◽  
Vol 58 (12) ◽  
pp. 1093-1106 ◽  
Author(s):  
Deepa Bhartiya ◽  
Sandhya Kasiviswanathan ◽  
Sreepoorna K. Unni ◽  
Prasad Pethe ◽  
Jayesh V. Dhabalia ◽  
...  
Keyword(s):  
Stem Cell ◽  
Germ Cells ◽  
Stem Cell Marker ◽  
Human Testis ◽  
Cell Marker ◽  
Adult Human
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