Comparison of efficacy and safety of topical triamcinolone acetonide paste 0.1% and fluticasone propionate spray 0.05% in the treatment of symptomatic oral lichen planus and their influence on quality of life

2012 ◽  
Vol 66 (4) ◽  
pp. AB188
2019 ◽  
Vol 24 (1) ◽  
pp. 301-308 ◽  
Author(s):  
Ioanina Parlatescu ◽  
Mihaela Tovaru ◽  
Carmen Larisa Nicolae ◽  
Ruxandra Sfeatcu ◽  
Andreea Cristiana Didilescu

Author(s):  
Dvorak Gabriella ◽  
Rappersberger Klemens ◽  
Rausch-Fan Xiao-hui ◽  
Bruckmann Corinna ◽  
Hofmann Eva

Abstract Objectives The aim of this study was to evaluate the relationship between personality traits and perceived treatment success in oral lichen planus. Material and methods A total of 53 patients with diagnosed oral lichen planus were evaluated at the time of diagnosis and along the course of their treatment. The visual analogue scale (VAS) was used for evaluating pain and burning sensation, along with an evaluation of the oral health-related quality of life (OHIP) and the clinical severity. In order to determine the personality trait, the NEO-FFI questionnaire was applied. Data were assessed with the statistical software Stata by a multiple linear regression. Results A significant relationship between the two personality traits: “conscientiousness” and “extraversion” and a perceived improvement in oral lichen planus could be observed. The higher the “conscientiousness,” the better the perceived oral health-related quality of life. Furthermore, “extraversion” had a significant influence on the improvement in clinical severity index (P < 0.05). Conclusions Personality traits, especially conscientiousness and extraversion, have a significant impact on the perception of therapeutic intervention in oral lichen planus. Clinical relevance As personalized patient management is gaining importance and psychosocial factors play a significant role in mucosal diseases, the patient’s psychological profile should be considered in the oral lichen planus management.


2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Mircea Tampa ◽  
Constantin Caruntu ◽  
Madalina Mitran ◽  
Cristina Mitran ◽  
Isabela Sarbu ◽  
...  

Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology with significant impact on patients’ quality of life. Malignant transformation into oral squamous cell carcinoma (OSCC) is considered as one of the most serious complications of the disease; nevertheless, controversy still persists. Various factors seem to be involved in the progression of malignant transformation; however, the mechanism of this process is not fully understood yet. Molecular alterations detected in OLP samples might represent useful biomarkers for predicting and monitoring the malignant progression. In this review, we discuss various studies which highlight different molecules as ominous predictors of OLP malignant transformation.


2015 ◽  
Vol 8 (2) ◽  
pp. 33-40 ◽  
Author(s):  
Gabriella Dvorak ◽  
Babak Monshi ◽  
Markus Hof ◽  
Thomas Bernhart ◽  
Corinna Bruckmann ◽  
...  

Author(s):  
Doina Iulia Rotaru ◽  
Radu Marcel Chisnoiu ◽  
Andreea Iuliana Kui ◽  
Sorana D. Bolboacă ◽  
Andrea Maria Chisnoiu

Background: oral lichen planus (OLP) is a mucocutaneous disease that affects about 4% of the global population. Hepatitis C virus (HCV) was linked to lichen planus. The current study aimed to assess the impact of OLP associated or not with HCV infection on the oral health-related quality of life (OHRQoL). Methods: The study included patients diagnosed with OLP who filled in the Romanian version of OHIP-14 questionnaire at their first appointment and 6 months later, after the OLP treatment. A control group of OLP-free subjects similar as age and sex was also included in the study. Results: 68 patients with OLP and 46 controls were included in the study. The OHIP scores are significantly higher on OLP group than controls (p-value < 0.0001) and significantly reduced at 6-month follow-up (p-values: < 0.0001 pre- vs. post-treatment in OLP group). Patients with and without HCV associated with OLP demonstrated a similar oral quality of life (p-values > 0.05). Conclusions: the OHRQoL for patients suffering from OLP is compromised but is improved after treatment. The HCV associated with OLP did not influence the overall OHRQoL, but the patients who associate HCV reported more frequently aching in the mouth and discomfort eating food at six-month follow-up.


2016 ◽  
Vol 2 (3) ◽  
pp. 147
Author(s):  
Indah Suasani Wahyuni ◽  
Tenny Setiana Dewi ◽  
Erna Herawati ◽  
Dewi Zakiawati

Oral lesion’s profi le in autoimmune disease. Oral lesions are commonly found in patients with autoimmune diseases as manifestations of the disease or a side effect of the treatment. Oral lesions must be handled properly to prevent secondary infection, relieve pain and improve the patient’s quality of life. The aim of this study is to describe oral lesions profile in patients with autoimmune diseases, including clinical characteristics and location of oral lesions as well as the distribution of age and sex of the patient. The methods were retrospective observation by describing the secondary data from patients with autoimmune handled by Oral Medicine Specialist, Faculty of Dentistry, University of Padjadjaran in dr. Hasan Sadikin Hospital Dental Clinic. Patient files from August 2010 untill August 2014 (n = 66) were used, with the most often diagnosis were Systemic Lupus erythematosus (SLE), Oral lichen planus (OLP) and Pemphigus vulgaris (PV). It is revealed that, the age of patients varied between 9 to 68 years old and there was predominance of female patients. Patients diagnosed with SLE were 26 (39.4%), 12 patients with OLP (18.2%) and 28 patients with PV (42.4%). Based on the clinical feature, the most commonly found type of oral lesion was erosion (n=52/78,8%), while the most commonly predilection was in the buccal mucosa (n = 46/69,7%). In conclusion, intra-oral examination should be used as a routine procedure in the comprehensive management of patients with autoimmune diseases. Dentist have a professional role in the diagnosis of oral lesions and provide appropriate therapy in order to improve the quality of life of patients with autoimmune diseases.ABSTRAKLesi oral biasa ditemukan pada penderita penyakit autoimun sebagai manifestasi penyakit atau efek samping pengobatan kortikosteroid jangka panjang. Lesi oral harus ditangani dengan baik untuk mencegah terjadinya infeksi sekunder, mengatasi rasa sakit dan meningkatkan kualitas hidup penderita. Pengumpulan data gambaran profil lesi oral penderita penyakit autoimun, meliputi karakteristik klinis dan lokasi lesi oral serta distribusi usia dan jenis kelamin penderita belum pernah dilakukan. Metode yang digunakan adalah non eksperimen, retrospektif dan deskripsi data sekunder penderita autoimun yang ditangani oleh bagian Ilmu Penyakit Mulut FKG Universitas Padjadjaran di SMF Gigi dan Mulut RS dr. Hasan Sadikin Bandung. Data pasien yang dipergunakan antara bulan Agustus 2010 sampai Agustus 2014 (n=66), dengan diagnosis penyakit autoimun yang paling sering adalah Sistemic Lupus Erythematous (SLE), Oral Lichen Planus  (OLP) dan Pemphigus Vulgaris (PV). Semua pasien memberikan persetujuan pada saat dilakukan pemeriksaan dan  pengumpulan data melalui informed consent. Hasil penelitian ini menunjukkan usia penderita bervariasi antara 9 hingga 68 tahun dan jumlah penderita wanita lebih banyak daripada pria. Penderita yang didiagnosis SLE 26 orang (39,4%), OLP 12 orang (18,2%) dan PV 28 orang (42,4%). Berdasarkan gambaran klinisnya jenis lesi oral yang banyak ditemukan adalah erosi (n = 52/ 78,8%) dan berdasarkan lokasi lesi oral banyak ditemukan pada mukosa bukal (n = 46/69,7% penderita). Kesimpulannya, pemeriksaan intra oral disarankan menjadi prosedur rutin dalam tatalaksana komprehensif penderita penyakit autoimun. Dokter gigi diharapkan dapat berperan dalam mendiagnosis lesi oral dan memberikan terapi yang tepat sehingga dapat meningkatkan kualitas hidup penderita penyakit autoimun. 


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