scholarly journals Markers of Oral Lichen Planus Malignant Transformation

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Mircea Tampa ◽  
Constantin Caruntu ◽  
Madalina Mitran ◽  
Cristina Mitran ◽  
Isabela Sarbu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Squamous Cell Carcinoma ◽  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Chronic Inflammatory Disease ◽  
Unknown Etiology ◽  
Molecular Alterations ◽  
Oral Lichen

Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology with significant impact on patients’ quality of life. Malignant transformation into oral squamous cell carcinoma (OSCC) is considered as one of the most serious complications of the disease; nevertheless, controversy still persists. Various factors seem to be involved in the progression of malignant transformation; however, the mechanism of this process is not fully understood yet. Molecular alterations detected in OLP samples might represent useful biomarkers for predicting and monitoring the malignant progression. In this review, we discuss various studies which highlight different molecules as ominous predictors of OLP malignant transformation.

scholarly journals The Characteristics of Patients with Oral Lichen Planus and Malignant Transformation—A Retrospective Study of 271 Patients

2021 ◽  
Vol 18 (12) ◽  
pp. 6525
Author(s):  
Vladimíra Radochová ◽  
Romana Koberová Ivančaková ◽  
Ondřej Heneberk ◽  
Radovan Slezák
Keyword(s):  
Retrospective Study ◽  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Chronic Inflammatory Disease ◽  
University Hospital ◽  
Unknown Etiology ◽  
Transformation Rate ◽  
Oral Lichen

Introduction: Oral lichen planus (OLP) is a chronic inflammatory disease with an unknown etiology rating among oral potentially malignant disorder. The aim of the study was to determine the epidemiological and clinical characteristics of the patients with OLP and rate of malignant transformation. Patients and methods: Data were obtained from the medical records of 271 patients referred to the Oral Medicine Unit at the University Hospital in Hradec Králové diagnosed with oral lichen planus in the period of 2003–2020. The records were retrospectively analyzed. The following clinical data were retrieved from the medical charts: gender, age, systemic diseases, alcohol and tobacco consumption, localization/clinical appearance of lesions, distribution of the lesions, presence of the symptoms, treatment provided and malignant transformation. Results: A total of 271 charts of patients with confirmed diagnosis of OLP were retrospectively analyzed, of whom, 66.4% (180/271) were women and 33.6% (91/271) were men. The mean age of the patients was 56.0 (18.2–85.0) years. The median follow-up of all patients was 15.2 months. Overall, 2 patients (2/271, 0.74%) meeting the above-mentioned criteria for malignant transformation were identified during the follow-up period. Both patients suffered from erosive type OLP and developed squamous cell carcinoma of the tongue. Conclusions: This retrospective study is in concordance with other studies showing the similar profile and clinical features of the patients with OLP. Malignant transformation rate was 0.74%.

Oral health–related quality of life in different clinical forms of oral lichen planus

2019 ◽  
Vol 24 (1) ◽  
pp. 301-308 ◽  
Author(s):  
Ioanina Parlatescu ◽  
Mihaela Tovaru ◽  
Carmen Larisa Nicolae ◽  
Ruxandra Sfeatcu ◽  
Andreea Cristiana Didilescu
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Health Related Quality ◽  
Clinical Forms ◽  
Related Quality ◽  
Health Related ◽  
Oral Lichen

scholarly journals Effect of personality traits on the oral health-related quality of life in patients with oral lichen planus undergoing treatment

2020 ◽  
Author(s):  
Dvorak Gabriella ◽  
Rappersberger Klemens ◽  
Rausch-Fan Xiao-hui ◽  
Bruckmann Corinna ◽  
Hofmann Eva
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Personality Traits ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Oral Lichen

Abstract Objectives The aim of this study was to evaluate the relationship between personality traits and perceived treatment success in oral lichen planus. Material and methods A total of 53 patients with diagnosed oral lichen planus were evaluated at the time of diagnosis and along the course of their treatment. The visual analogue scale (VAS) was used for evaluating pain and burning sensation, along with an evaluation of the oral health-related quality of life (OHIP) and the clinical severity. In order to determine the personality trait, the NEO-FFI questionnaire was applied. Data were assessed with the statistical software Stata by a multiple linear regression. Results A significant relationship between the two personality traits: “conscientiousness” and “extraversion” and a perceived improvement in oral lichen planus could be observed. The higher the “conscientiousness,” the better the perceived oral health-related quality of life. Furthermore, “extraversion” had a significant influence on the improvement in clinical severity index (P < 0.05). Conclusions Personality traits, especially conscientiousness and extraversion, have a significant impact on the perception of therapeutic intervention in oral lichen planus. Clinical relevance As personalized patient management is gaining importance and psychosocial factors play a significant role in mucosal diseases, the patient’s psychological profile should be considered in the oral lichen planus management.

Gender aspects in oral health-related quality of life of oral lichen planus patients

2015 ◽  
Vol 8 (2) ◽  
pp. 33-40 ◽  
Author(s):  
Gabriella Dvorak ◽  
Babak Monshi ◽  
Markus Hof ◽  
Thomas Bernhart ◽  
Corinna Bruckmann ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Gender Aspects ◽  
Oral Lichen

scholarly journals The Influence of Hepatitis C Virus Infection on ORAL Health-Related Quality of Life in Patients with Oral Lichen Planus

2021 ◽  
Vol 18 (17) ◽  
pp. 9382
Author(s):  
Doina Iulia Rotaru ◽  
Radu Marcel Chisnoiu ◽  
Andreea Iuliana Kui ◽  
Sorana D. Bolboacă ◽  
Andrea Maria Chisnoiu
Keyword(s):  
Quality Of Life ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Health Related Quality ◽  
P Values ◽  
Related Quality ◽  
Health Related ◽  
Oral Lichen

Background: oral lichen planus (OLP) is a mucocutaneous disease that affects about 4% of the global population. Hepatitis C virus (HCV) was linked to lichen planus. The current study aimed to assess the impact of OLP associated or not with HCV infection on the oral health-related quality of life (OHRQoL). Methods: The study included patients diagnosed with OLP who filled in the Romanian version of OHIP-14 questionnaire at their first appointment and 6 months later, after the OLP treatment. A control group of OLP-free subjects similar as age and sex was also included in the study. Results: 68 patients with OLP and 46 controls were included in the study. The OHIP scores are significantly higher on OLP group than controls (p-value < 0.0001) and significantly reduced at 6-month follow-up (p-values: < 0.0001 pre- vs. post-treatment in OLP group). Patients with and without HCV associated with OLP demonstrated a similar oral quality of life (p-values > 0.05). Conclusions: the OHRQoL for patients suffering from OLP is compromised but is improved after treatment. The HCV associated with OLP did not influence the overall OHRQoL, but the patients who associate HCV reported more frequently aching in the mouth and discomfort eating food at six-month follow-up.

scholarly journals Risk co-factors inducing malignant transformation of oral lichen planus: A literature review of clinical studies

2021 ◽  
Vol 5 (1) ◽  
pp. 005-011
Author(s):  
Saleh Wafaa ◽  
Youssef Jilan M ◽  
Ata Fatma ◽  
Anees Mohamed M ◽  
Cha Seunghee ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Hepatitis C ◽  
Malignant Transformation ◽  
Lichen Planus ◽  
Potential Risk ◽  
Clinical Studies ◽  
Animal Studies ◽  
Oral Lichen Planus ◽  
Chronic Inflammatory Disease ◽  
Oral Lichen

Oral lichen planus (OLP) is an autoimmune chronic inflammatory disease. The potential risk of malignant transformation in OLP remains controversial. The aim of the present study was to review original clinical studies published in indexed databases, which assessed the potential risk cofactors which were implicated in the malignant transformation of oral lichen planus. We focused our search to include most of the studies that reported malignant transformation of oral lichen planus using different combinations of the following key indexing terms: oral lichen planus, malignant transformation, smoking, alcohol, chronic inflammation, candida, human papillomavirus (HPV), hepatitis C virus (HCV) and immunosuppression. The animal studies were excluded from our study. Despite a dearth of studies on this topic we have identified consumption of tobacco and/or alcohol, the presence of erosive and/or atrophic areas, infection with candida, HCV, HPV, and immunosuppression as significant cofactors. Patients with OLP with these risk co-factors are at risk of malignant transformation should, therefore be followed up for an extensive period or even for life.

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