The protective effect of sunscreens, vitamin E 6% cream, and betamethasone 0.1% cream on solar-simulating radiation-induced erythema and neutrophil influx

SummaryThe effect of alfa-tocopherol on the cell-cell interactions at the vessel wall were studied, using an in vitro model of human umbilical vein endothelial cell cultures (HUEC). Immune triggered granulocytes (PMN) will adhere to and damage HUEC and platelets enhance this PMN mediated endothelial injury. When HUEC are cultured in the presence of vitamin E, 51Cr-leakage induced by complement stimulated PMN is significantly decreased and the enhanced cytotoxicity by platelets is completely abolished (p <0.001).The inhibition of PMN induced endothelial injury is directly correlated to a diminished adherence of PMN to vitamin E- cultured HUEC (p <0.001), which may be mediated by an increase of both basal and stimulated endogenous prostacyclin (PGI2) from alfa-tocopherol-treated HUEC (p <0.025). The vitamin E-effect is abolished by incubation of HUEC with the irreversible cyclo-oxygenase inhibitor, acetylsalicylic acid, but the addition of exogenous PGI2 could not reproduce the vitamin E-mediated effects.We conclude that vitamin E exerts a protective effect on immune triggered endothelial damage, partly by increasing the endogenous anti-oxidant potential, partly by modulating intrinsic endothelial prostaglandin production. The failure to reproduce vitamin E-protection by exogenously added PGI2 may suggest additional, not yet elucidated vitamin E-effects on endothelial metabolism.

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Protective Effect of Hypoxia Against Radiation Induced Fibrosis in the Rat Gut

Acta Radiologica Oncology Radiation Physics Biology ◽

10.3109/02841867909128191 ◽

1979 ◽

Vol 18 (1) ◽

pp. 65-75 ◽

Cited By ~ 4

Author(s):

J. O. Forsberg ◽

H. Jiborn ◽

B. Jung

Keyword(s):

Protective Effect ◽

Radiation Induced ◽

Rat Gut

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Protective effect of titanium tetrafluoride and silver diamine fluoride on radiation-induced dentin caries in vitro

Scientific Reports ◽

10.1038/s41598-021-85748-8 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Beatriz Martines de Souza ◽

Mayara Souza Silva ◽

Aline Silva Braga ◽

Patrícia Sanches Kerges Bueno ◽

Paulo Sergio da Silva Santos ◽

...

Keyword(s):

Lactic Acid ◽

Protective Effect ◽

Acid Production ◽

Lactic Acid Production ◽

Negative Control ◽

Titanium Tetrafluoride ◽

Silver Diamine Fluoride ◽

Dentin Caries ◽

Radiation Induced

AbstractThis in vitro study evaluated the protective effect of titanium tetrafluoride (TiF4) varnish and silver diamine fluoride (SDF) solution on the radiation-induced dentin caries. Bovine root dentin samples were irradiated (70 Gy) and treated as follows: (6 h): 4% TiF4 varnish; 5.42% NaF varnish; 30% SDF solution; placebo varnish; or untreated (negative control). Microcosm biofilm was produced from human dental biofilm (from patients with head-neck cancer) mixed with McBain saliva for the first 8 h. After 16 h and from day 2 to day 5, McBain saliva (0.2% sucrose) was replaced daily (37 °C, 5% CO2) (biological triplicate). Demineralization was quantified by transverse microradiography (TMR), while biofilm was analyzed by using viability, colony-forming units (CFU) counting and lactic acid production assays. The data were statistically analyzed by ANOVA (p < 0.05). TiF4 and SDF were able to reduce mineral loss compared to placebo and the negative control. TiF4 and SDF significantly reduced the biofilm viability compared to negative control. TiF4 significantly reduced the CFU count of total microorganism, while only SDF affected total streptococci and mutans streptococci counts. The varnishes induced a reduction in lactic acid production compared to the negative control. TiF4 and SDF may be good alternatives to control the development of radiation-induced dentin caries.

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