Use of mesenchymal stem cells to improve healing of second degree burn wound and improve split-thickness skin graft outcome

2019 ◽  
Vol 81 (4) ◽  
pp. AB144 ◽  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Skin Graft ◽  
Split Thickness Skin Graft ◽  
Burn Wound ◽  
Graft Outcome ◽  
Thickness Skin ◽  
Degree Burn ◽  
Second Degree

scholarly journals Effect of mesenchymal stem cells versus aloe vera on healing of deep second-degree burn

2021 ◽  
Vol 8 ◽  
pp. 12-12
Author(s):  
Nahla Imbarak ◽  
H. Ismail Abdel-Aziz ◽  
Lamiaa M. Farghaly ◽  
Somaya Hosny
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Aloe Vera ◽  
Degree Burn ◽  
Second Degree

scholarly journals Managing Neglected Burn Wound with Exposed Upper Tibia Using Multiple Modalities

2013 ◽  
Vol 2 (3) ◽  
pp. 142-146
Author(s):  
Cherry G Kalangi ◽  
Agus Hariyanto ◽  
Mendy Hatibie Oley
Keyword(s):  
Knee Joint ◽  
Skin Graft ◽  
Muscle Flap ◽  
Left Knee ◽  
Medial Gastrocnemius ◽  
Split Thickness Skin Graft ◽  
Hospital Data ◽  
Burn Wound ◽  
Muscle Contracture ◽  
Thickness Skin

Background: Deep burn wound with exposed underlying structures such as muscle or moreover in this case, bone, may increase morbidity in the terms of infection. Therefore careful planning of reconstruction is needed. Patient and Method: We report one case of neglected burn wound with exposed tibia and muscle contracture on bilateral knee joint that was reconstructed in our Plastic Surgery Division of Prof RD Kandou Hospital. Data was taken from medical and surgery record. Result: We managed the muscle contracture of the left knee joint by sedated gradual stretching and splinting. We also utilized hyperbaric treatment in order to maximize granulation process. A medial gastrocnemius muscle flap followed by split thickness skin graft is used to reconstruct the missing tissue at upper tibia, and another split thickness skin graft to cover another wound at opposite upper leg. The result was satisfying without any complication. Conclusion: In managing a neglected burn wound with bone exposed and muscle contracture, it is compulsory to have a careful reconstruction planning. Our objectives are to release the muscle contracture and to provide an adequate coverage to the bone-exposed wound by using many modalities we have.

Clinical Therapeutic Effect of Sheet Split-Thickness Skin Graft with Micropores in Repairing Third-Degree Burn Wounds on the Hands

2016 ◽  
Vol 57 ◽  
pp. 74-80
Author(s):  
Xiaopeng Zheng ◽  
Tiansheng Chen ◽  
Lisen Zhang ◽  
Ruibin Cheng ◽  
Fei Chang ◽  
...  
Keyword(s):  
Therapeutic Effect ◽  
Skin Graft ◽  
Split Thickness Skin Graft ◽  
Burn Wounds ◽  
Thickness Skin ◽  
Degree Burn

scholarly journals Application Of Allo Mesenchymal Stem Cells On Chronic Burn Wound: Case Series Report

2018 ◽  
Vol 4 (1) ◽  
pp. 68-72 ◽  
Author(s):  
Aditya Wardhana ◽  
Isabella Kurnia Liem ◽  
Lauda Feroniasanti ◽  
Dyah Juliana Pudjiti ◽  
Fajar Mujadid ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Wound Healing ◽  
Mesenchymal Stem Cells ◽  
Umbilical Cord ◽  
Skin Graft ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Burn Wound ◽  
Severe Burns

Background : Severe burns are among the commonly occurring trauma with lethal outcome. One of the important aspects of severe burn therapy is to quickly achieve wound healing. Previous reports indicated that mesenchymal stem cells (MSCs) therapy contributes in facilitating better wound healing. In this report, we investigated the effects of MSCs derived from human bone marrow and umbilical cord on wound healing in patients with severe burns and its mechanism. Method : We performed human bone marrow and human umbilical cord MSCs therapy on 3 severe burns patients. Two of the patients had inadequate donor to close raw surface with skin graft, whilst one patient had infected chronic burn wound which have failed to epithelialize despite repeated attempts of skin graft and wound care. Result : We observed that MSCs therapy significantly accelerated wound healing. The effects after MSCs migrated into wound were decreased infiltration of inflammatory cells and faster epithelialization. Conclusion : This study suggests that MSCs therapy has positive effects in improving wound healing in severe burns patients. Data provided by this research may serve as theoretical basis for further study of MSCs application in burn wound therapy.

Our Experience of Tie Over bolster and Quilting Sutures Versus Stapler fixation for Split thickness skin graft in post burn neck contracture – A Comparative study

2021 ◽  
Vol 8 (2) ◽  
pp. 58-61
Author(s):  
Dr. Ganesh Chaudhari ◽  
Dr. Satish Sonawane
Keyword(s):  
Comparative Study ◽  
Skin Graft ◽  
Comfort Level ◽  
Split Thickness Skin Graft ◽  
Medical College ◽  
Graft Outcome ◽  
Thickness Skin ◽  
Time Required ◽  
Mean Time ◽  
Quilting Suture

Background: Traditional method to fix Split thickness skin graft in post burn neck contracture is Tie over Bolster dressing and Quilting sutures. We used staplers to fix split thickness skin graft. Materials & methods: A comparative study conducted in 30 patients with post burn neck contracture at Dr. Vasantrao Pawar Medical College, Nashik, during January 2015 to December 2020. Time required for fixation of split thickness skin graft, outcome in terms of graft uptake and patients comfort level while removing sutures and stapler recorded. Results: Total 30 Patients were included in our study. Mean time required for Tie over and quilting suture was 10.53 ± 0.88 min, significantly higher than the mean time in stapler fixation 4.87 ± 0.81 min. (p<0.001). Graft take was 95% in stapler and 93% in Tie over and quilting suture. Conclusion: Fixation of Split thickness skin graft with stapler is more rapid, less time consuming also results in decreased surgical and anaesthesia time. More patient friendly while removing staplers with comparable skin graft uptake.

scholarly journals Nanostructured Cellulose–Gellan–Xyloglucan–Lysozyme Dressing Seeded with Mesenchymal Stem Cells for Deep Second-Degree Burn Treatment

2021 ◽  
Vol Volume 16 ◽  
pp. 833-850
Author(s):  
Carolina Maria Costa de Oliveira Souza ◽  
Clayton Fernandes de Souza ◽  
Bassam Felipe Mogharbel ◽  
Ana Carolina Irioda ◽  
Celia Regina Cavichiolo Franco ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Burn Treatment ◽  
Degree Burn ◽  
Second Degree

Improving Outcomes in Anterolateral Thigh Flap Donor-Site Reconstruction Using Propeller Flaps: A Retrospective Comparative Study with Skin Grafting

2020 ◽  
Author(s):  
Domenico Pagliara ◽  
Maria Lucia Mangialardi ◽  
Stefano Vitagliano ◽  
Valentina Pino ◽  
Marzia Salgarello
Keyword(s):  
Comparative Study ◽  
Skin Graft ◽  
Donor Site ◽  
Split Thickness Skin Graft ◽  
Tactile Sensitivity ◽  
Aesthetic Outcome ◽  
Propeller Flap ◽  
Thickness Skin ◽  
Anterolateral Thigh ◽  
Alt Flap

Abstract Background After anterolateral thigh (ALT) flap harvesting, skin graft of the donor site is commonly performed. When the defect width exceeds 8 cm or 16% of thigh circumference, it can determine lower limb function impairment and poor aesthetic outcomes. In our comparative study, we assessed the functional and aesthetic outcomes related to ALT donor-site closure with split-thickness skin graft compared with thigh propeller flap. Methods We enrolled 60 patients with ALT flap donor sites. We considered two groups of ALT donor-site reconstructions: graft group (30 patients) with split-thickness skin graft and flap group (30 patients) with local perforator-based propeller flap. We assessed for each patient the range of motion (ROM) at the hip and knee, tension, numbness, paresthesia, tactile sensitivity, and gait. Regarding the impact on daily life activities, patients completed the lower extremity functional scale (LEFS) questionnaire. Patient satisfaction for aesthetic outcome was obtained with a 5-point Likert scale (from very poor to excellent). Results In the propeller flap group, the ROMs of hip and knee and the LEFS score were significantly higher. At 12-month follow-up, in the graft group, 23 patients reported tension, 19 numbness, 16 paresthesia, 22 reduction of tactile sensitivity, and 5 alteration of gait versus only 5 patients experienced paresthesia and 7 reduction of tactile sensitivity in the propeller flap group. The satisfaction for aesthetic outcome was significantly higher in the propeller flap group. Conclusion In high-tension ALT donor-site closure, the propeller perforator flap should always be considered to avoid split-thickness skin graft with related functional and aesthetic poor results.

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