Effect of mesenchymal stem cells versus aloe vera on healing of deep second-degree burn

Objective: Current treatment for second-degree burn wounds, including silver sulfadiazine (SSD) application, may cause side effects such as delayed and incomplete wound healing, leaving a scar. Traditional plants empirically used for burn wounds, such as Aloe vera, seem to be a promising option with good safety profiles. Methods: We therefore compared Aloe vera to SSD for second-degree burn wounds based on a review of clinical trials obtained by an organized search through the Cochrane, PubMed, and DynaMed databases. Three randomized clinical trials studies were selected, two of which were critically appraised. The third study, with a different outcome assessment, was analyzed separately. Results: Two studies showed that Aloe vera was more effective in treating second-degree burn wounds than SSD 1% with an absolute risk reduction of 0.2, relative risk reduction of 0.83–1.0, and number needed to treat five patients. The Aloe vera group showed faster healing, earlier epithelialization, and earlier pain alleviation. The third study combined Aloe vera with other herbs, which showed better healing ability and restored skin hydration than those with SSD. Conclusion: Each of the three articles stated that Aloe vera was more effective than SSD for treating second-degree burn wounds. Nevertheless, each of the studies lacked methodology and comprehensive data reporting.

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The influence of Aloe vera with mesenchymal stem cells from dental pulp on bone regeneration: characterization and treatment of non-critical defects of the tibia in rats

Journal of Applied Oral Science ◽

10.1590/1678-7757-2018-0103 ◽

2019 ◽

Vol 27 ◽

Cited By ~ 6

Author(s):

Isadora Mello Vilarinho SOARES ◽

Gustavo Vicentis de Oliveira FERNANDES ◽

Larissa Cordeiro CAVALCANTE ◽

Yulla Klinger Pereira de Carvalho LEITE ◽

Dayseanny de Oliveira BEZERRA ◽

...

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Bone Regeneration ◽

Dental Pulp ◽

Aloe Vera

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Induced pluripotent stem cells-derived microvesicles accelerate deep second-degree burn wound healing in mice through miR-16-5p-mediated promotion of keratinocytes migration

Theranostics ◽

10.7150/thno.46639 ◽

2020 ◽

Vol 10 (22) ◽

pp. 9970-9983

Author(s):

Yuan Yan ◽

Ruijun Wu ◽

Yunyao Bo ◽

Min Zhang ◽

Yinghua Chen ◽

...

Keyword(s):

Stem Cells ◽

Wound Healing ◽

Induced Pluripotent Stem Cells ◽

Pluripotent Stem Cells ◽

Burn Wound ◽

Burn Wound Healing ◽

Degree Burn ◽

Induced Pluripotent ◽

Second Degree

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Comparison of therapeutic effects of encapsulated Mesenchymal stem cells in Aloe vera gel and Chitosan-based gel in healing of grade-II burn injuries

Regenerative Therapy ◽

10.1016/j.reth.2021.02.007 ◽

2021 ◽

Vol 18 ◽

pp. 30-37

Author(s):

Esmaeel Sharifi ◽

Mohammad Chehelgerdi ◽

Ali Fatahian-Kelishadrokhi ◽

Farshad Yazdani-Nafchi ◽

Korosh Ashrafi-Dehkordi

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Aloe Vera ◽

Burn Injuries ◽

Therapeutic Effects ◽

Aloe Vera Gel ◽

Grade Ii

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The Effect of Myrtus, Honey, Aloe vera and Pseudomonas Phage Treatment on Infected Second Degree Burns: in vivo Study

Biointerface Research in Applied Chemistry ◽

10.33263/briac111.74227430 ◽

2020 ◽

Vol 11 (1) ◽

pp. 7422-7430

Keyword(s):

Pseudomonas Aeruginosa ◽

Wound Healing ◽

Aloe Vera ◽

Wound Contraction ◽

Control Group ◽

Burn Wounds ◽

Degree Burn ◽

Significant Difference ◽

Hematoxylin Eosin ◽

Second Degree

Many researches have been exerted to find an application dressing for wound healing and also attain a considerable microbial reduction in burn wounds. In this study, the healing effect of a mixed herbal ointment (containing Myrtus, honey, Aloe vera, and pseudomonas phage) on the healing process of second degree burn wounds infected with Pseudomonas aeruginosa in comparison was evaluated. For this purpose, a hot metal square piece (4×2 cm, 50 g) was applied using a standard burning technique, and the applied pressure on the skin kept the same for all animals, then infected with Pseudomonas aeruginosa. Rats were randomly divided into 2 groups. Group 1 was treated with mixed herbal ointment, and group 2 received no treatment (control group). The treatment was daily, and sampling was weekly for three consecutive weeks (7, 14, and 21-day). Formalin 10% was used for tissue fixation. Wound healing in test and control groups was investigated by macroscopic and microscopic methods using Hematoxylin-Eosin staining. It wound contraction evaluation (Image J software). Macroscopic findings showed that wound contraction of the mixed herbal ointment group was significantly higher than the control group for 21 days. Hematoxylin-Eosin staining revealed that the epithelialization was considerably more completed in the mixed herbal ointment group in comparison with the control group. Also, neovascularization was significantly higher in the mixed herbal ointment group. The comparative results demonstrated that the mixed herbal ointment group had a significant difference (P<0.05) with a non-treated group (control). Therefore, the mixed herbal ointment is suggested as a suitable candidate for the treatment of second-degree burn wounds infected to pseudomonas aeruginosa.

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Effect of different concentrations of Aloe vera leave\'s extract on the healing process of rat\'s second degree burn

Journal of Basic Research in Medical Sciences ◽

10.18869/acadpub.jbrms.3.4.34 ◽

2016 ◽

Vol 3 (4) ◽

pp. 34-39

Author(s):

Kholoud Ramz ◽

Naser Abbasi ◽

Mohammadreza Hafeziahmadi ◽

Monireh Azizi ◽

Azim Hedayatpour ◽

...

Keyword(s):

Healing Process ◽

Aloe Vera ◽

Degree Burn ◽

Second Degree

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Comparison of the effectiveness of Aloe Vera Gel with 2% Nitrofurazone ointment on the healing of superficial second-degree burns. Randomised clinical trial

10.21203/rs.3.rs-16854/v1 ◽

2020 ◽

Author(s):

Shokoh Varaei ◽

Hadi Ranjbar ◽

Parichehr Sabaghzadeh ◽

Sanaz Bostani ◽

Soodabhe Amirsalari

Keyword(s):

Clinical Trial ◽

Assessment Tool ◽

Aloe Vera ◽

The Body ◽

Burn Wound ◽

Aloe Vera Gel ◽

Degree Burn ◽

Significant Difference ◽

The Mean ◽

Second Degree

Abstract Background Burn injuries are one of the most common sources of trauma globally that comprise a significant drain on long-term personal and healthcare cost Large surface area burn wounds are difficult to manage and may result in significant physiologic and psychological sequelae . The aim of this study was to compare the effectiveness of Aloe Vera gel with Nitrofurazone ointment in the healing of superficial second-degree burn wounds.Methods The present study was a split body controlled, randomized clinical trial. The sample was recruited from patients with superficial second-degree burn wound who were prescribed to treat with 2% Nitrofurazone ointment. Thirty patients with at least two burn, each burn on an alternate side of the body, entered the study — samples allocated to two groups which received Aloe Vera gel or 2% Nitrofurazone ointment on their burns. Bates-Jensen Wound assessment tool (BWAT) was used to evaluate the healing of burns. The burns were evaluated before, one, two and three weeks after the beginning of treatment.Results The mean ± SD of BWAT scores in Aloe Vera zones were 30.32 ± 3.28, 27.33 ± 3.38, 21.33 ± 3.13, 16.12 ± 2.16 respectively (F(2, 65.07) =440.00, p=0.001). The mean ± SD of BWAT scores in Nitrofurazone ointment zones were 30.51 ± 3.79, 28.45 ± 3.49, 23.36 ± 2.89, 19.23 ± 2.11 (F(1, 52.00) =228.00, p=0.001).Conclusions There is a significant difference in (BWAT) scores between intervention and control groups. Aloe Vera gel was as effective as Nitrofurazone ointment in the treatment of superficial second-degree burns.Trial registration IRCT2014113020151N1. Registered 14 December 2014, https://www.irct.ir/trial/17874

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