27538 Characteristics of patients with psoriasis differ by obesity status and history of metabolic comorbidities

Introduction: Myocardial fibrosis is a key feature of heart failure, and its mechanisms are incompletely understood. It has been postulated that advanced glycation end-products (AGEs) form an etiologic link between diabetes and its vascular complications. Binding of AGEs to the cellular receptor for AGEs (RAGE) induces a state of increased oxidative stress, inflammation and fibrosis. Circulating soluble RAGEs (sRAGE) compete with cellular RAGE for the binding of AGEs which reduces the activation of the AGE-RAGE mediated pro-inflammatory and pro-fibrotic signaling pathways. We hypothesize that low levels of sRAGE will be associated with higher risk of heart failure. Methods: We conducted a prospective analysis of a random subsample of 1,157 participants from the ARIC Study who attended visit 2 (1990-1992). We included participants without a history of heart disease or heart failure, and with measured plasma sRAGE levels. Incident heart failure was defined as death from health failure or hospitalization due to heart failure. Results: In this community-based population (mean age 63 years, 60% women, 78% white), there were 132 incident cases of heart failure during approximately 20 years of follow up. Lower levels of sRAGE were significantly and independently associated with an increased risk of heart failure (Table). Analyses stratified by diabetes status at baseline showed that the risk of heart failure among those in the lowest quartile, compared to those in the upper quartile, was consistent but stronger among persons with diabetes compared to those without diabetes with HR=5.31 (95%CI 1.05-26.76) versus HR=2.50 (95%CI, 1.22-5.13), respectively. We did not observe any significant interactions by race or obesity status. Conclusions: Lower circulating levels of sRAGE are independently associated with the development of heart failure in older adults. These results highlight the pathophysiological role of the AGE-RAGE-sRAGE axis even among persons without diabetes.

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The Natural History of Metabolic Comorbidities in Turner Syndrome from Childhood to Early Adulthood: Comparison between 45,X Monosomy and Other Karyotypes

Frontiers in Endocrinology ◽

10.3389/fendo.2018.00027 ◽

2018 ◽

Vol 9 ◽

Cited By ~ 10

Author(s):

Yael Lebenthal ◽

Sigal Levy ◽

Efrat Sofrin-Drucker ◽

Nessia Nagelberg ◽

Naomi Weintrob ◽

...

Keyword(s):

Natural History ◽

Turner Syndrome ◽

Early Adulthood ◽

History Of ◽

Metabolic Comorbidities

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Parenting With a Substance Abuse History: The Moderating Role of Parenting Behaviors on Obesity and Internalizing Symptoms in Adolescence

Youth & Society ◽

10.1177/0044118x18815274 ◽

2018 ◽

Vol 52 (8) ◽

pp. 1436-1456

Author(s):

H. Isabella Lanza ◽

Patricia Pittman ◽

Yih-Ing Hser

Keyword(s):

Substance Abuse ◽

Internalizing Symptoms ◽

Emotional Health ◽

Parenting Behaviors ◽

Hierarchical Regression ◽

Physical Discipline ◽

Obesity Status ◽

History Of ◽

The Relationship

Although numerous studies have shown that child obesity is associated with internalizing symptoms, relatively few studies have examined the role of parenting behaviors on this relationship. Youth meeting obesity status may be at higher risk of psychosocial maladjustment when exposed to more vulnerable parenting contexts. The current study interviewed mothers with a history of substance abuse to assess whether parenting behaviors moderated the relationship between obesity and internalizing symptoms among adolescents ( N = 160; 51% girls; M = 12.76 years). Hierarchical regression analyses identified physical discipline as a moderator; girls meeting obesity status displayed higher levels of internalizing symptoms when exposed to higher versus lower levels of physical discipline. Prevention/intervention efforts targeting mothers with substance abuse histories should aim to not only improve physical and emotional health but also highlight the connections between physical and emotional health and the influence of parenting behaviors on associations.

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Bedside Point-of-Care Ultrasound of an Adult with Diffuse Intermittent Abdominal Pain

Acute Medicine Journal ◽

10.52964/amja.0798 ◽

2020 ◽

Vol 19 (1) ◽

pp. 49-51

Author(s):

Jamaji C Nwanaji-Enwerem ◽

◽

Adaira Landry ◽

Keyword(s):

Emergency Department ◽

Abdominal Pain ◽

Point Of Care ◽

Sudden Onset ◽

Point Of Care Ultrasound ◽

Intermittent Abdominal Pain ◽

Obesity Status ◽

History Of ◽

History Of Obesity ◽

New Onset

A 29-year-old woman with a history of obesity status post Roux-en-Y gastric bypass greater than five years prior presented to the emergency department with four hours of sudden-onset stabbing left-sided abdominal pain associated with nausea and non-bloody emesis. She denied melaena and hematochezia, but did report two weeks of diarrhoea that was unchanged with this new onset abdominal pain.

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Asthma in Youth and Early-Onset Type 2 Diabetes: A Nationwide Study of 1.72 Million Israeli Adolescents

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/clinem/dgab542 ◽

2021 ◽

Author(s):

Michael Shapiro ◽

Chen Arbel ◽

Inbar Zucker ◽

Gingy Ronen Balmor ◽

Miri Lutski ◽

...

Keyword(s):

Type 2 Diabetes ◽

Early Onset ◽

Military Service ◽

Population Based ◽

Diabetes Registry ◽

Compulsory Military Service ◽

Obesity Status ◽

Develop Type ◽

History Of

Abstract Background The prevalence of both asthma and early onset diabetes is on the rise, however the association between them remains unclear. We examined a possible association of asthma at adolescence with type 2 diabetes in young adulthood. Methods This is a nationwide, population-based study of 1,718,541 Israeli adolescents (59% males; mean age 17.3 years; range 16-19 years), examined before compulsory military service during 1992-2016, with data linked to the Israeli National Diabetes Registry. Asthma diagnosis and severity were determined by a board-certified pulmonologist and based on spirometry tests. Results Type 2 diabetes developed in 58/9,090 (0.64%), 507/97,059 (0.52%), 114/23,332 (0.49%), and 7,095/1,589,060 (0.44%) persons with moderate-to-severe, mild, inactive, and no history of asthma, respectively, during a mean follow-up >13 years. The respective odds ratios (ORs) were 1.33 (95%CI, 1.02-1.74), 1.17 (1.06-1.28), and 1.09 (0.9-1.31), considering those without asthma history as the reference, in a model adjusted for birth year, sex, BMI, and other socio-demographic variables. The association persisted when the analysis accounted for coexisting morbidities, and when persons without asthma, individually matched by age, sex, birth year, and BMI were the reference. Both mild and moderate-to-severe asthma were associated with type 2 diabetes before age 35 years: ORs 1.18 (1.05-1.34) and 1.44 (1.05-2.00), respectively. The strength of the association was accentuated over time. The effect was unchanged when adjusted for oral and inhaled glucocorticoid use. Conclusion Adolescents with active asthma have higher risk to develop type 2 diabetes. This seems related to disease severity, independent of adolescent obesity status, apparent before age 35 years, and more pronounced in recent years

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DIFFERENCES OF TODDLER OBESITY BASED ON EXCLUSIVE BREASTFEEDING HISTORY IN TEGALREJO HEALTH CENTER, YOGYAKARTA

Epidemiology and Society Health Review (ESHR) ◽

10.26555/eshr.v3i1.3635 ◽

2021 ◽

Vol 3 (1) ◽

pp. 21

Author(s):

Suci Musvita Ayu ◽

Arini Mayang Fa'uni

Keyword(s):

Health Center ◽

Exclusive Breastfeeding ◽

Bivariate Analysis ◽

Control Group ◽

Case Group ◽

Obese Children ◽

Children Under Five ◽

Under Five ◽

Obesity Status ◽

History Of

Background: Obesity is a global problem and continues to affect low and middle-income countries, mainly urban areas. In Indonesia, the obesity rate of children was 11.5% and was ranked 21st in the world by 2016. Even according to WHO, the number of obese children will continue to increase every year. Several studies have shown that a history of exclusive breastfeeding can reduce the risk of obesity in toddlers. This study aimed to determine the differences in the obesity status of children under five based on a history of exclusive breastfeeding in the Tegalrejo Health Center, Yogyakarta City.Methods: This research employed an analytical observational study with a case-control design. The research sample consisted of 34 toddlers aged 6-24 months, calculated using the difference of two proportions: 17 cases of obese children under five and 17 controls under five who were not obese. A questionnaire was used to collect the data. A Chi-square test was used to analyse the data.Results: There were children under five without exclusive breastfeeding in the group of as many as 41.7% and 29.4% in the control group. 52,9% of children in the case group had exclusive breastfeeding, and 70% in the control group. The bivariate analysis showed no difference in the obesity status of children under five based on a history of exclusive breastfeeding with a value of p = 0.480 and OR = 2.133 (95% CI = 0.519-8.751).Conclusions: There was no difference in the obesity status of children under five based on a history of exclusive breastfeeding, but children without a history of exclusive breastfeeding were 2.133 times more likely to have obesity than children with exclusive breastfeeding.

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