Geographical Distribution of Systemic Sclerosis in Canada: An Ecological Study based on the Canadian Scleroderma Research Group

Author(s):  
Anastasiya Muntyanu ◽  
Lydia Ouchene ◽  
Siriu Zhou ◽  
Marie Hudson ◽  
Mohsen Rezaeian ◽  
...  
Author(s):  
José Carmine Dianese ◽  
Carlos Antônio Inácio ◽  
Anibal Alves de Carvalho-Junior ◽  
Maria do Desterro Mendes dos Santos ◽  
Taimy Cantillo-Pérez ◽  
...  

In this review, we present an historic account of the work on the diversity of fungi associated with plants of the Cerrado Biome, including an overview of the studies carried out by the research group of the Mycological Collection connected to the Herbarium UB (Universidade de Brasília), and the rust fungi in Herbarium IBI (Instituto Biológico, São Paulo). The contributions to Cerrado mycology from the early 19th century to the present days were highlighted. Illustrative maps were included to show the geographical distribution of the main fungal groups, associated with native plants of the Cerrado, belonging to the five predominant orders: Pucciniales (rust fungi), Phyllachorales (tar-spot fungi), Capnodiales (cercosporoid fungi: Family Mycosphaerellaceae), as well as Meliolales and Asterinales (black mildews).


2018 ◽  
Vol 70 (11) ◽  
pp. 1829-1834 ◽  
Author(s):  
Veronika K. Jaeger ◽  
Gabriele Valentini ◽  
Eric Hachulla ◽  
Franco Cozzi ◽  
Oliver Distler ◽  
...  

2013 ◽  
Vol 03 (02) ◽  
pp. 113-118 ◽  
Author(s):  
Vikram Tangri ◽  
Carly Hewson ◽  
Murray Baron ◽  
A. Bonner ◽  
Marvin Fritzler ◽  
...  

2011 ◽  
Vol 38 (7) ◽  
pp. 1326-1328 ◽  
Author(s):  
KYLE M. WALKER ◽  
JANET POPE

Objective.The European League Against Rheumatism/EULAR Scleroderma Trials and Research group (EULAR/EUSTAR) has published recommendations for the management of systemic sclerosis (SSc). Members of the Scleroderma Clinical Trials Consortium and the Canadian Scleroderma Research Group were surveyed regarding their level of agreement with the recommendations.Methods.A survey containing the 14 EULAR/EUSTAR recommendations asked participants to indicate their level of agreement with each on a 10-point scale, from 0 (not at all) to 9 (completely agree). The survey was sent to 117 people, and 66 replies were received (56% response rate).Results.Exceptions to generally high agreement included the use of iloprost and bosentan for digital vasculopathy, methotrexate for skin involvement, and bosentan and epoprostenol for pulmonary arterial hypertension (PAH; all < 69% agreement, defined as ≥ 7 rating). Vasculopathy and PAH treatment had differences in agreement between North America and Europe (p < 0.006). Respondents who were EULAR/EUSTAR recommendation authors shared a similar level of agreement compared to those who were not, except for the use of proton pump inhibitors for the prevention of SSc-related gastroesophageal reflux disease, esophageal ulcers, and strictures.Conclusion.EULAR/EUSTAR recommendations were relatively well accepted among SSc experts. Overall reduced agreement may be due to the modest efficacy of some agents (such as methotrexate for the skin). Some regional disagreement is likely because of access differences.


2010 ◽  
Vol 63 (1) ◽  
pp. 142-149 ◽  
Author(s):  
Sarit Khimdas ◽  
Sarah Harding ◽  
Ash Bonner ◽  
Brittany Zummer ◽  
Murray Baron ◽  
...  

2013 ◽  
Vol 40 (4) ◽  
pp. 447-454 ◽  
Author(s):  
Samah Mansour ◽  
Ashley Bonner ◽  
Chayawee Muangchan ◽  
Marie Hudson ◽  
Murray Baron ◽  
...  

Objective.In systemic lupus erythematosus, socioeconomic status (SES) affects outcomes. SES can modify outcomes by altering timing of access to care and adherence. It is unknown whether SES affects systemic sclerosis (SSc) outcomes. Disease can affect income and cause work disability, thus education (completed long before SSc onset) may be a proxy for SES.Methods.The Canadian Scleroderma Research Group collects annual data on patients with SSc. Baseline data were used from a prevalent cohort. Education was stratified by whether participants completed high school. Regression models assessed effects of education on organ complications and survival.Results.In our study, 1145 patients with SSc had 11.0 ± 9.5 years' disease duration; 86% were women, with a mean age of 55.4 ± 12.1 years. About one-quarter did not complete high school; this was more common in older patients (p < 0.0001), men (p = 0.017), those with lower income (p < 0.0001), the unemployed (p < 0.054), smokers (p < 0.001), where DLCO was < 70% predicted (p = 0.009), in those with arthritis (p = 0.047), higher Health Assessment Questionnaire-Disability Index (p = 0.017), elevated erythrocyte sedimentation rate (p = 0.019), median C-reactive protein (p = 0.002), proteinuria (p = 0.016), steroid use ever (p = 0.039), and those more likely to have died in followup (12.7% vs 8.0%; p = 0.024). However, adjusting for confounders, there was no effect of education on mortality; whereas mortality was related to age, diffuse cutaneous SSc (dcSSc) subset, elevated pulmonary arterial (PA) pressure on echocardiography, low forced vital capacity expressed as percentage of predicted, and proteinuria (similar in the dcSSc subset and in limited cutaneous SSc), mortality was increased in older patients, those with elevated PA pressure, and those with low DLCO.Conclusion.Completing less education than high school was not associated with a worse prognosis in SSc after adjustment for confounding characteristics.


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