scholarly journals Binocular reading in children following extraction of a dense congenital or infantile unilateral cataract

2020 ◽  
Vol 24 (4) ◽  
pp. 228.e1-228.e7
Author(s):  
Krista R. Kelly ◽  
Reed M. Jost ◽  
Serena X. Wang ◽  
David R. Stager ◽  
Eileen E. Birch
Keyword(s):  
Unilateral Cataract

A Novel Missense Mutation in the Gene Encoding Major Intrinsic Protein (MIP) in a Giant Panda with Unilateral Cataract Formation

2020 ◽  
Author(s):  
Chao Bai ◽  
Yuyan You ◽  
Xuefeng Liu ◽  
Maohua Xia ◽  
Wei Wang ◽  
...  
Keyword(s):  
Missense Mutation ◽  
Conformational Changes ◽  
Giant Panda ◽  
Ailuropoda Melanoleuca ◽  
Major Intrinsic Protein ◽  
Gene Encoding ◽  
Functional Candidate Gene ◽  
Intrinsic Protein ◽  
Age Related ◽  
Unilateral Cataract

Abstract Background: Cataracts are defects of the lens that cause progressive visual impairment and ultimately blindness in many vertebrate species. Most cataracts are age-related, but up to one third have an underlying genetic cause. Cataracts are common in captive zoo animals, but it is often unclear whether these are congenital or acquired (age-related) lesions. Results: Here we used a functional candidate gene screening approach to identify mutations associated with cataracts in a captive giant panda (Ailuropoda melanoleuca). We screened 11 genes often associated with human cataracts and identified a novel missense mutation (c.686G>A) in the MIP gene encoding major intrinsic protein. This is expressed in the lens and normally accumulates in the plasma membrane of lens fiber cells, where it plays an important role in fluid transport and cell adhesion. The mutation causes the replacement of serine with asparagine (p.S229N) in the C-terminal tail of the protein, and modeling predicts that the mutation induces conformational changes that may interfere with lens permeability and cell–cell interactions.Conclusion: The c.686G>A mutation was found in a captive giant panda with a unilateral cataract but not in 18 controls from diverse regions in China, suggesting it is most likely a genuine disease-associated mutation rather than a single-nucleotide polymorphism. The mutation could therefore serve as a new genetic marker to predict the risk of congenital cataracts in captive giant pandas.

Bilateral morphometric analysis of corneal sub-basal nerve plexus in patients undergoing unilateral cataract surgery: a preliminary in vivo confocal microscopy study

2020 ◽  
pp. bjophthalmol-2019-315449 ◽  
Author(s):  
Giuseppe Giannaccare ◽  
Federico Bernabei ◽  
Marco Pellegrini ◽  
Fabio Guaraldi ◽  
Federica Turchi ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Cataract Surgery ◽  
Nerve Fibre ◽  
Fibre Length ◽  
Nerve Plexus ◽  
In Vivo Confocal Microscopy ◽  
Corneal Nerve ◽  
Branch Density ◽  
Unilateral Cataract

AimsTo evaluate bilateral morphometric changes of corneal sub-basal nerve plexus (CSNP) occurring after unilateral cataract surgery by in vivo confocal microscopy (IVCM) images analysed with automated software.MethodsIVCM was performed before (V0) and 1 month after surgery (V1) in both operated eyes (OEs) and unoperated eyes (UEs) of 30 patients. Thirty age and sex-matched subjects acted as controls. Corneal nerve fibre density (CNFD), corneal nerve branch density (CNBD), corneal nerve fibre length (CNFL), corneal nerve total branch density (CTBD), corneal nerve fibre area (CNFA), corneal nerve fibre width, corneal nerve fractal dimension (CNFrD) and dendritic cells density were calculated.ResultsMean CNFD, CNBD, CNFL, CTBD, CNFA and CNFrD significantly decreased at V1 versus V0 in both eyes (respectively, 15.35±7.00 vs 21.21±6.56 n/mm2 in OEs and 20.11±6.69 vs 23.20±7.26 in UEs; 13.57±12.16 vs 26.79±16.91 n/mm2 in OEs and 24.28±14.88 vs 29.76±15.25 in UEs; 9.67±3.44 mm/mm2 vs 13.49±3.42 in OEs and 12.53±3.60 vs 14.02±3.82 in UEs; 22.81±18.77 vs 42.25±24.64 n/mm2 in OEs and 38.06±20.52 vs 43.93±22.27 in UEs; 0.0040±0.0021 vs 0.0058±0.0020 mm2/mm2 in OEs and 0.0049±0.0016 vs 0.0057±0.0019 in UEs; 1.418±0.058 vs 1.470±0.037 in OEs and 1.466±0.040 vs 1.477±0.036 in UEs; always p<0.049).ConclusionPatients undergoing cataract surgery exhibit bilateral alterations of CSNP. This finding could have broad implications in the setting of sequential cataract surgery.

scholarly journals Corneal Changes in Children after Unilateral Cataract Surgery in the Infant Aphakia Treatment Study

Ophthalmology ◽  
2015 ◽  
Vol 122 (11) ◽  
pp. 2186-2192 ◽  
Author(s):  
David G. Morrison ◽  
Michael J. Lynn ◽  
Sharon F. Freedman ◽  
Faruk H. Orge ◽  
Scott R. Lambert
Keyword(s):  
Cataract Surgery ◽  
Unilateral Cataract

scholarly journals Unilateral cataract associated with eyelid ash-leaf macule in tuberous sclerosis complex

2018 ◽  
pp. bcr-2018-224923
Author(s):  
Rajalakshmi Selvaraj ◽  
Nirupama Kasturi ◽  
Pooja Kumari ◽  
Sabreesh Muraleedharan
Keyword(s):  
Tuberous Sclerosis ◽  
Tuberous Sclerosis Complex ◽  
Congenital Cataract ◽  
Male Child ◽  
Periocular Region ◽  
Unilateral Cataract

A 9-month-old male child with tuberous sclerosis complex presented with ash-leaf macules on the left periocular region and ipsilateral dense cataract. Fundus showed retinal astrocytic hamartomas. This case is reported for unilaterality of congenital cataract on the same side of eyelid ash-leaf macule in tuberous sclerosis.

Unilateral Cataract from Electricity

1911 ◽  
Vol 141 (1) ◽  
pp. 154
Author(s):  
EDWARD JACKSON ◽  
T. B. SCHNEIDEMAN
Keyword(s):  
Unilateral Cataract
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