Oral administration of endotoxins modulates allergen-induced immune reactions in a rat model of food allergy*1

2004 ◽  
Vol 113 (2) ◽  
pp. S238
Author(s):  
D QUARCOO
Keyword(s):  
Food Allergy ◽  
Oral Administration ◽  
Rat Model ◽  
Immune Reactions

Mechanism of Traditional Medicine Tongfeng Li’an Granules on Hyperuricemic Rats Based on Regulating Uric Acid Transporter

2021 ◽  
Vol 15 (4) ◽  
pp. 536-541
Author(s):  
Xiangpei Zhao ◽  
Li Li ◽  
Chuanmei Zhong ◽  
Hongli Teng ◽  
Guodong Huang
Keyword(s):  
Uric Acid ◽  
Oral Administration ◽  
Natural Product ◽  
Serum Uric Acid ◽  
Rat Model ◽  
Regulatory Mechanism ◽  
High Dose ◽  
Model Group ◽  
Serum Biochemical ◽  
Acid Transporter

Hyperuricemia (HUA) is a metabolic disorder of purine metabolism which leads to the increase of serum uric acid. Tongfeng Lian granule (TFLA) is a clinical empirical traditional herb prescription in China, is biobased natural product material. To study its regulatory mechanism on uric acid transporter in rats with HUA, the rat model of hyperuricemic was established by oral administration of potassium oxazinate (1.5 g/kg) and adenine (0.05 g/kg). The related indexes were detected to evaluate the uric Acid Transporter after treat with TFLA. In the results, compared with model group, the high dose TFLA can reduce the levels of Related serum biochemical indexes (*P < 0.05, **P < 0.01). TFLA could reduce the levels of URAT1, GLUT9 and increase the expression of OAT3 in kidney. In conclusion, TFLA can effectively inhibit the level of serum uric acid with hyperuricemia rats, and the possible mechanism related to TFLA inhibiting the reabsorption of uric acid by URAT1 and GLUT9, promoting the secretion of OAT3 and uric acid into urine.

Oral administration of kaempferol inhibits bone loss in rat model of ovariectomy-induced osteopenia

2017 ◽  
Vol 69 (5) ◽  
pp. 1113-1119 ◽  
Author(s):  
Beata Nowak ◽  
Agnieszka Matuszewska ◽  
Anna Nikodem ◽  
Jarosław Filipiak ◽  
Marcin Landwójtowicz ◽  
...  
Keyword(s):  
Bone Loss ◽  
Oral Administration ◽  
Rat Model

Determination of allergenicity of different food allergens in a rat model of food allergy

2003 ◽  
Vol 111 (2) ◽  
pp. S251
Author(s):  
B. Ahrens ◽  
D. Quarcoo ◽  
A. Meeuw ◽  
J. Zagon ◽  
G. Reese ◽  
...  
Keyword(s):  
Food Allergy ◽  
Rat Model ◽  
Food Allergens

Pancreatic Regeneration by Long-Term Oral Administration of a Protease Inhibitor in a Rat Model of Chronic Pancreatitis

2011 ◽  
Vol 140 (5) ◽  
pp. S-550
Author(s):  
Michiaki Takii ◽  
Yoshifumi Arisaka ◽  
Daisuke Masuda ◽  
Reiko Ashida ◽  
Kazuhide Higuchi
Keyword(s):  
Chronic Pancreatitis ◽  
Oral Administration ◽  
Protease Inhibitor ◽  
Rat Model ◽  
Pancreatic Regeneration

Oral Administration of Bacterial Lysates Attenuates Experimental Food Allergy

2011 ◽  
Vol 156 (2) ◽  
pp. 196-204 ◽  
Author(s):  
Birgit Ahrens ◽  
David Quarcoo ◽  
Sabine Buhner ◽  
Paolo M. Matricardi ◽  
Eckard Hamelmann
Keyword(s):  
Food Allergy ◽  
Oral Administration ◽  
Bacterial Lysates

Probiotics Have a Different Immunomodulatory Potential in vitro versus ex vivo upon Oral Administration in Children with Food Allergy

2007 ◽  
Vol 143 (3) ◽  
pp. 237-244 ◽  
Author(s):  
A.E. Flinterman ◽  
E.F. Knol ◽  
A.G. van Ieperen-van Dijk ◽  
H.M. Timmerman ◽  
A.C. Knulst ◽  
...  
Keyword(s):  
Food Allergy ◽  
Oral Administration ◽  
Ex Vivo ◽  
Immunomodulatory Potential

scholarly journals Comparison of intestinal APC subsets from homeostatic and immunostimulatory environments

2021 ◽  
Author(s):  
◽  
Kerry Hilligan
Keyword(s):  
T Cells ◽  
Food Allergy ◽  
Immune Responses ◽  
Oral Administration ◽  
Mesenteric Lymph Nodes ◽  
Adaptive Immune Responses ◽  
Naive T Cells ◽  
Naïve T Cells ◽  
Adaptive Immune ◽  
Inflammatory Bowel

<p>Antigen presenting cells (APC) including dendritic cells (DC) play a key role in the initiation and direction of adaptive immune responses. Acting as sentinels in the tissue, DC sample antigen and traffic to the local lymph node where they present antigen to naïve T cells. The signals DC provide to naïve T cells determines the functional fate of the T cell and therefore, the type of immune response generated. At mucosal sites, such as the intestine, immune responses need to be carefully regulated due to the high antigenic load. For this reason, intestinal immune cells are highly specialised to prevent immune activation to innocuous antigens while still holding the capacity to induce potent responses to pathogenic microbes and helminths. Oral administration of antigen is associated with tolerance and the generation of FoxP3+ regulatory T cells (Tregs). Specialised lamina propria (LP) resident APC are required for the initiation of Treg differentiation in the mesenteric lymph nodes (MLN) through production of chemical mediators such as retinoic acid (RA). Ablation of these populations or restricted trafficking prevents the development of Tregs in mouse models thus supporting the essential role of APC in maintaining intestinal homeostasis. During infection, APC promote the induction of adaptive immune responses which neutralise threats. However, the APC subsets involved in this are not well defined. Pathologies such as food allergy and inflammatory bowel disease are thought to arise due to the development of aberrant immune responses. Food allergy can be modelled in mice using the mucosal adjuvant cholera toxin (CT) which has been shown to drive immunity to co-delivered antigens and is associated with the generation of IL-4 producing T helper 2 cells. Understanding the APC subsets involved in the initiation of intestinal immune responses could help in the development of targeted therapies for inflammatory bowel conditions. In this thesis, I show that oral administration of CT is followed by the appearance of a novel phenotype of DC in the intestinal LP and MLN. These DC differ functionally from DC at steady-state and may contribute to the generation of IL-4 producing T cells observed in the LP, MLN and spleen following oral administration of CT.</p>

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