GM-CSF Pathway Defects May Account for Reduced Neutrophil Chemotaxis in Atopic Dermatitis

2007 ◽  
Vol 119 (1) ◽  
pp. S238 ◽  
Author(s):  
L.G. Bankova ◽  
M.E. Brummet ◽  
B.S. Bochner ◽  
D.N. Grigoryev ◽  
K.C. Barnes ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Neutrophil Chemotaxis ◽  
Gm Csf

scholarly journals Inhibitory Effects of Luteolin 7-Methyl Ether Isolated from Wikstroemia ganpi on Tnf-A/Ifn-Γ Mixture-Induced Inflammation in Human Keratinocyte

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4387
Author(s):  
Jonghwan Jegal ◽  
Tae-Young Kim ◽  
No-June Park ◽  
Beom-Geun Jo ◽  
Geon-A. Jo ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Methyl Ether ◽  
Therapeutic Agent ◽  
Inflammatory Diseases ◽  
Hacat Cells ◽  
Inhibitory Effects ◽  
Gm Csf ◽  
Human Keratinocyte ◽  
Tnf Α ◽  
Ifn Γ

Plants of the genus Wikstroemia are traditionally used in China to treat various inflammatory diseases. The purpose of this study was to isolate the components of Wikstroemia ganpi (Siebold & Zucc.) Maxim., to evaluate their anti-atopic activities and to identify candidates with anti-atopic therapeutics. A total of 24 compounds were isolated by bioassay-guided separation, including one novel compound, which was tilianin 5-methyl ether. The anti-atopic activities of the isolated compounds were determined using TNF-α-treated RBL-2H3 cells and HaCaT cells. The mRNA expressions of IL-4, IL-6, GM-CSF, G-CSF and TRPV1 were reduced by luteolin 7-methyl ether. The study shows that the luteolin 7-methyl ether isolated from W. ganpi is a potential therapeutic agent for the treatment of atopic dermatitis.

scholarly journals Differential regulation of neutrophil chemotaxis to IL-8 and fMLP by GM-CSF: lack of direct effect of oestradiol

Immunology ◽  
2006 ◽  
Vol 117 (2) ◽  
pp. 205-212 ◽  
Author(s):  
Li Shen ◽  
Jennifer M. Smith ◽  
Zheng Shen ◽  
Stephen B. Hussey ◽  
Charles R. Wira ◽  
...  
Keyword(s):  
Direct Effect ◽  
Differential Regulation ◽  
Neutrophil Chemotaxis ◽  
Gm Csf

Analysis of GM-CSF gene polymorphisms (3606T/C and 3928C/T) in Japanese patients with atopic dermatitis

2006 ◽  
Vol 31 (2) ◽  
pp. 278-280 ◽  
Author(s):  
H. Saeki ◽  
Y. Tsunemi ◽  
N. Asano ◽  
K. Nakamura ◽  
T. Sekiya ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Gene Polymorphisms ◽  
Japanese Patients ◽  
Gm Csf

scholarly journals Haplopine Ameliorates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions in Mice and TNF-α/IFN-γ-Induced Inflammation in Human Keratinocyte

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 806
Author(s):  
Tae-Young Kim ◽  
Ye Jin Kim ◽  
Jonghwan Jegal ◽  
Beom-Geun Jo ◽  
Han-Seok Choi ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Skin Lesions ◽  
Skin Thickness ◽  
Dependent Manner ◽  
Active Components ◽  
Concentration Dependent Manner ◽  
Gm Csf ◽  
Tnf Α ◽  
Protein Expressions

This study aimed to investigate the anti-inflammatory, antioxidant, and anti-atopic dermatitis (AD) effects of haplopine, which is one of the active components in D. dasycarpus. Haplopine (12.5 and 25 mM) inhibited the mRNA expressions of inflammatory cytokines IL-6, TSLP, GM-CSF, and G-CSF and the protein expressions of IL-6 and GM-CSF in TNF-α/INF-γ-stimulated HaCaT cells. In H2O2-induced Jukat T cells, haplopine (25 and 50 mM) suppressed the productions of proinflammatory cytokines (IL-4, IL-13, and COX-2) and increased the mRNA and protein expressions of oxidative stress defense enzymes (SOD, CAT, and HO-1) in a concentration-dependent manner. In vivo, haplopine significantly attenuated the development of AD symptoms in 2,4-dinitrochlorobenzene (DNCB)-stimulated Balb/c mice, as evidenced by reduced clinical dermatitis scores, skin thickness measurements, mast cell infiltration, and serum IgE concentrations. These findings demonstrate that haplopine should be considered a novel anti-atopic agent with the potential to treat AD.

Synergy between IL-8 and GM–CSF in reproductive tract epithelial cell secretions promotes enhanced neutrophil chemotaxis

2004 ◽  
Vol 230 (1) ◽  
pp. 23-32 ◽  
Author(s):  
Li Shen ◽  
John V. Fahey ◽  
Stephen B. Hussey ◽  
Susana N. Asin ◽  
Charles R. Wira ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Reproductive Tract ◽  
Neutrophil Chemotaxis ◽  
Gm Csf

scholarly journals The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced byDermatophagoides farinaeAllergen in NC/Nga Mice

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Rosa Mistica C. Ignacio ◽  
Hyun-Suk Kwak ◽  
Young-Uk Yun ◽  
Ma. Easter Joy V. Sajo ◽  
Yang-Suk Yoon ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Serum Levels ◽  
Hydrogen Water ◽  
Gm Csf ◽  
Beneficial Effects ◽  
Oxidation Reduction ◽  
Oxidation Reduction Potential ◽  
Immunological Effect ◽  
Th1 And Th2 Responses ◽  
Allergic Contact

Hydrogen water (HW) produced by electrolysis of water has characteristics of extremely low oxidation-reduction potential (ORP) value and high dissolved hydrogen (DH). It has been proved to have various beneficial effects including antioxidant and anti-inflammatory effects; however, HW effect on atopic dermatitis (AD), an inflammatory skin disorder, is poorly documented. In the present study, we examined the immunological effect of drinking HW onDermatophagoides farinae-induced AD-like skin in NC/Nga mice. Mice were administered with HW and purified water (PW) for 25 days. We evaluated the serum concentration of pro-inflammatory (TNF-α), Th1 (IFN-γ, IL-2, and IL-12p70), Th2 (IL-4, IL-5, and IL-10), and cytokine expressed by both subsets (GM-CSF) to assess their possible relationship to the severity of AD. The serum levels of cytokines such as IL-10, TNF-α, IL-12p70, and GM-CSF of mice administered with HW was significantly reduced as compared to PW group. The results suggest that HW affects allergic contact dermatitis through modulation of Th1 and Th2 responses in NC/Nga mice. This is the first note on the drinking effect of HW on AD, clinically implying a promising potential remedy for treatment of AD.

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