TLR2 Agonist Enhances CD8+Foxp3+ Regulatory T cells and Limits Th2 Immune Response during Allergen Immunotherapy

Regulatory T cells (Tregs) is heterogenic subpopulation of T cells that is able to suppress function of effector cells during the immune response. Among them are natural (nTreg) and induced Treg (Tr1, Th3, CD4+CD25-). CD25, CD45Ro, CD152, GITR, LAG-3, several adhesion molecules, chemokine receptors as well as Toll-like receptors are present on the surface of Treg. Mechanism of suppression used by nTreg is not completely understood.

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Exogenous C3 protein enhances the adaptive immune response to polymicrobial sepsis through down-regulation of regulatory T cells

International Immunopharmacology ◽

10.1016/j.intimp.2011.11.022 ◽

2012 ◽

Vol 12 (1) ◽

pp. 271-277 ◽

Cited By ~ 12

Author(s):

Yujie Yuan ◽

Jianan Ren ◽

Shougen Cao ◽

Weiwei Zhang ◽

Jieshou Li

Keyword(s):

Immune Response ◽

T Cells ◽

Regulatory T Cells ◽

Adaptive Immune Response ◽

Polymicrobial Sepsis ◽

Down Regulation ◽

Adaptive Immune

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In Vivo-Generated Antigen-Specific Regulatory T Cells Treat Autoimmunity Without Compromising Antibacterial Immune Response

Science Translational Medicine ◽

10.1126/scitranslmed.3008895 ◽

2014 ◽

Vol 6 (241) ◽

pp. 241ra78-241ra78 ◽

Cited By ~ 55

Author(s):

S. Kasagi ◽

P. Zhang ◽

L. Che ◽

B. Abbatiello ◽

T. Maruyama ◽

...

Keyword(s):

Immune Response ◽

T Cells ◽

Regulatory T Cells

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Helicobacter pylori Infection: Regulatory T Cells and Their Participation in the Immune Response

Jundishapur Journal of Microbiology ◽

10.5812/jjm.5183 ◽

2013 ◽

Vol 6 (4) ◽

Cited By ~ 3

Author(s):

Tania Beatriz Romero-Adriàn ◽

Jorymar Leal-Montiel

Keyword(s):

Immune Response ◽

T Cells ◽

Helicobacter Pylori ◽

Regulatory T Cells

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Analysis of regulatory T cells and CTLA-4 expression in pregnant women according to seropositivity to Toxoplasma gondii

Parasitology ◽

10.1017/s0031182020000475 ◽

2020 ◽

Vol 147 (7) ◽

pp. 810-815

Author(s):

Karine Rezende-Oliveira ◽

César Gómez-Hernández ◽

Marcos Vinicius da Silva ◽

Fernanda Rodrigues Helmo ◽

Virmondes Rodrigues

Keyword(s):

Immune Response ◽

T Cells ◽

Toxoplasma Gondii ◽

Regulatory T Cells ◽

Pregnant Women ◽

Positive Serology ◽

Surface Molecules

AbstractPregnancy is considered a period in which immunomodulation occurs, although it is important for the maintenance of the foetus, could contribute to infections as Toxoplasma gondii. Immune response cells such as regulatory T cells participate in this immunomodulation, and surface molecules such as CTLA-4 develop an immunosuppressive role, could contribute to the establishment of the parasite. This study aimed to evaluate the presence of regulatory T cells and the expression of CTLA-4 in parturient and non-pregnant seropositive and seronegative for anti-T. gondii antibodies. Sixty-two participants were evaluated, 14 parturient with negative serology, 23 parturient with positive serology, 16 non-pregnant women seronegative and 9 non-pregnant women seropositive. Immunophenotyping was performed for characterize TCD4+Foxp3+ cells, T CD4+CD25-Foxp3+, TCD4+CD25highFoxp3+, TCD4+CTLA-4+, TCD4+CD25-CTLA-4+ and TCD4+CD25highCTLA-4+. We observed a lower level of CD4+CD25highFoxp3+ cells from seropositive parturient compared with seropositive non-pregnant cells. Significative levels of CD4+CD25-Foxp3+ cells from seronegative pregnant were observed compared with seropositive pregnant cells. Furthermore, the higher level of CD4+CD25-CTLA-4+ cells populations was detected in seropositive pregnant cells compared with seropositive non-pregnant. Although a significant increase in CTLA-4 cells was observed in pregnant women positive for anti-T. gondii antibodies, this increase did not cause a risk of reactivation of the infection.

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