Serotonin 2A receptor polymorphism rs3803189 mediated by dynamics of default mode network: a potential biomarker for antidepressant early response

2021 ◽  
Vol 283 ◽  
pp. 130-138
Author(s):  
Yurong Sun ◽  
Shiwan Tao ◽  
Shui Tian ◽  
Junneng Shao ◽  
Zhaoqi Mo ◽  
...  
Keyword(s):  
Default Mode Network ◽  
Early Response ◽  
Serotonin 2A Receptor ◽  
Default Mode ◽  
Potential Biomarker ◽  
Serotonin 2A ◽  
Receptor Polymorphism

A Potential Biomarker in Sports-Related Concussion: Brain Functional Connectivity Alteration of the Default-Mode Network Measured with Longitudinal Resting-State fMRI over Thirty Days

2015 ◽  
Vol 32 (5) ◽  
pp. 327-341 ◽  
Author(s):  
David C. Zhu ◽  
Tracey Covassin ◽  
Sally Nogle ◽  
Scarlett Doyle ◽  
Doozie Russell ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Default Mode Network ◽  
Resting State ◽  
Resting State Fmri ◽  
Default Mode ◽  
Potential Biomarker ◽  
Brain Functional Connectivity

Serotonin-2A receptor polymorphism (102T/C) in mood disorders

1999 ◽  
Vol 87 (2-3) ◽  
pp. 233-237 ◽  
Author(s):  
Shih-Jen Tsai ◽  
Chen-Jee Hong ◽  
Ching-Chi Hsu ◽  
Chih-Ya Cheng ◽  
Wen-Yu Liao ◽  
...  
Keyword(s):  
Mood Disorders ◽  
Serotonin 2A Receptor ◽  
Serotonin 2A ◽  
Receptor Polymorphism

Default Mode Network: Potential Biomarker for Mild Cognitive Impairment in Parkinson’s Disease

2015 ◽  
Vol 96 (10) ◽  
pp. e91-e92 ◽  
Author(s):  
Sandra Kletzel ◽  
Brett Harton ◽  
Alicia Kopicki ◽  
Amy A. Herrold ◽  
Tanya Simuni ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Default Mode Network ◽  
Default Mode ◽  
Potential Biomarker

scholarly journals Differences in functional connectivity profiles as a predictor of response to anterior thalamic nucleus deep brain stimulation for epilepsy: a hypothesis for the mechanism of action and a potential biomarker for outcomes

2018 ◽  
Vol 45 (2) ◽  
pp. E7 ◽  
Author(s):  
Erik H. Middlebrooks ◽  
Sanjeet S. Grewal ◽  
Matthew Stead ◽  
Brian N. Lundstrom ◽  
Gregory A. Worrell ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Pilot Study ◽  
Functional Connectivity ◽  
Mechanism Of Action ◽  
Brain Stimulation ◽  
Default Mode Network ◽  
Refractory Epilepsy ◽  
Default Mode ◽  
Potential Biomarker ◽  
Deep Brain

OBJECTIVEDeep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) is a promising therapy for refractory epilepsy. Unfortunately, the variability in outcomes from ANT DBS is not fully understood. In this pilot study, the authors assess potential differences in functional connectivity related to the volume of tissue activated (VTA) in ANT DBS responders and nonresponders as a means for better understanding the mechanism of action and potentially improving DBS targeting.METHODSThis retrospective analysis consisted of 6 patients who underwent ANT DBS for refractory epilepsy. Patients were classified as responders (n = 3) if their seizure frequency decreased by at least 50%. The DBS electrodes were localized postoperatively and VTAs were computationally generated based on DBS programming settings. VTAs were used as seed points for resting-state functional MRI connectivity analysis performed using a control dataset. Differences in cortical connectivity to the VTA were assessed between the responder and nonresponder groups.RESULTSThe ANT DBS responders showed greater positive connectivity with the default mode network compared to nonresponders, including the posterior cingulate cortex, medial prefrontal cortex, inferior parietal lobule, and precuneus. Interestingly, there was also a consistent anticorrelation with the hippocampus seen in responders that was not present in nonresponders.CONCLUSIONSBased on their pilot study, the authors observed that successful ANT DBS in patients with epilepsy produces increased connectivity in the default mode network, which the authors hypothesize increases the threshold for seizure propagation. Additionally, an inhibitory effect on the hippocampus mediated through increased hippocampal γ-aminobutyric acid (GABA) concentration may contribute to seizure suppression. Future studies are planned to confirm these findings.

The serotonin-2A receptor polymorphism and smoking behavior in Japan

2004 ◽  
Vol 14 (4) ◽  
pp. 195-197 ◽  
Author(s):  
Hayato Terayama ◽  
Masahiro Itoh ◽  
Isao Fukunishi ◽  
Kazuhiko Iwahashi
Keyword(s):  
Smoking Behavior ◽  
Serotonin 2A Receptor ◽  
Serotonin 2A ◽  
Receptor Polymorphism

Increased Default Mode Network Connectivity Following EEG Neurofeedback in PTSD

2012 ◽  
Author(s):  
Rosemarie Kluetsch ◽  
Tomas Ros ◽  
Jean Theberge ◽  
Paul Frewen ◽  
Christian Schmahl ◽  
...  
Keyword(s):  
Default Mode Network ◽  
Network Connectivity ◽  
Default Mode ◽  
Eeg Neurofeedback

Default mode network connections supporting intra-individual variability in typically developing primary school children: An EEG study.

2020 ◽  
Vol 34 (7) ◽  
pp. 811-823
Author(s):  
Evgeniya Yu. Privodnova ◽  
Helena R. Slobodskaya ◽  
Andrey V. Bocharov ◽  
Alexander E. Saprigyn ◽  
Gennady G. Knyazev
Keyword(s):  
Primary School ◽  
School Children ◽  
Default Mode Network ◽  
Individual Variability ◽  
Primary School Children ◽  
Typically Developing ◽  
Default Mode ◽  
Network Connections

Frequency domains of resting state default mode network activity in schizophrenia

2014 ◽  
Vol 45 (01) ◽  
Author(s):  
G Mingoia ◽  
K Langbein ◽  
M Dietzek ◽  
G Wagner ◽  
S Smesny ◽  
...  
Keyword(s):  
Default Mode Network ◽  
Resting State ◽  
Network Activity ◽  
Default Mode ◽  
Frequency Domains
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