scholarly journals 8. Long-Term Effects of Gay Straight Alliances On Perceived School Safety Among LGB Youth In Western Canada, Using A Novel Analytical Method To Enhance Causal Inference For Population Health Interventions

2019 ◽  
Vol 64 (2) ◽  
pp. S4-S5
Author(s):  
Elizabeth M. Saewyc ◽  
Amery Wu ◽  
Sheila Marshall ◽  
Gu Li ◽  
Ryan J. Watson ◽  
...  
Keyword(s):  
Causal Inference ◽  
Population Health ◽  
Analytical Method ◽  
School Safety ◽  
Health Interventions ◽  
Western Canada ◽  
Long Term Effects ◽  
Lgb Youth

scholarly journals Rapid, Precise and Affordable Estimation of Venlafaxine and Its Metabolites in Highly Polluted Effluent Waters: Proof-of-Concept for Methodology

Molecules ◽  
2020 ◽  
Vol 25 (20) ◽  
pp. 4793
Author(s):  
Snawar Hussain ◽  
Chandramouli Ramnarayanan ◽  
Teeka S. Roopashree ◽  
Md. Khalid Anwer ◽  
Nagaraja Sreeharsha ◽  
...  
Keyword(s):  
Analytical Method ◽  
Antidepressant Drug ◽  
Colorimetric Method ◽  
Parent Drug ◽  
Pharmaceutical Formulations ◽  
Effluent Treatment ◽  
Long Term Effects ◽  
Drug Molecules ◽  
Pharmacologically Active

Widespread presence of pharmaceuticals and their metabolites in the environment of industrialized countries is an emerging global concern. Potential contamination of the soil and water by such pharmacologically active substances poses serious ecotoxicological implications. Several studies assessing the long-term ecological risks of pharmaceutical contaminants mainly focus on the risk assessment of the parent drug, while the potential contributions of their metabolites is often neglected. Presence of selective serotonin and norepinephrine reuptake inhibitor venlafaxine, an antidepressant drug, and its metabolites is a matter of serious concern for aquatic systems, since they are difficult to remove by traditional wastewater treatment processes. The concentration of VEN present in water is reportedly one of the highest among pharmaceuticals; however, the long-term effects of its metabolites have not yet been systematically studied. Given the consideration to complex and time-consuming effluent treatment, and realizing the importance of levels of venlafaxine and its metabolites, a simple and accurate analytical method for quick determination is needed. We designed a selective colorimetric method by using oxidative coupling of drug molecules with 3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) reagent, to quantify the presence of venlafaxine and its metabolites in aquatic samples, with special emphasis on effluent. The method was validated for selectivity, specificity and robustness as per the ICH Q2 guidelines to assess its suitability in pharmaceutical samples, as well. Highly sensitive and green economical analytical method was successfully established for estimation of venlafaxine and its metabolites in aquatic samples. The method was quick, as it involved minimum processing steps. The method was accurate and linear in the range of 0.5 to 80 ppm and could successfully detect lowest concentration of 1.3 ppm, thus qualifying its applicability for the desired purpose to check the presence of trace levels of VEN or its metabolites in aquatic samples or in pharmaceutical formulations.

scholarly journals COVID-19 and Third Age: psychological relapses of “new behaviours”

2020 ◽  
Vol 3 (2) ◽  
pp. 137-143
Author(s):  
Guido Amoretti
Keyword(s):  
Social Relationships ◽  
Preventive Measures ◽  
Psychological Impact ◽  
The Elderly ◽  
Health Interventions ◽  
Individual Freedom ◽  
Long Term Effects ◽  
Self Sufficiency ◽  
The Family

Abstract The pandemic has forced many countries to introduce restrictions on individual freedom and to support the adoption of hygienically responsible behaviour in order to contain the spread of the infection. The elderly, one of the most fragile sections of the population, have paid and are paying the highest price in terms of contagion and deaths. In Italy, for example, the average age of patients who have died and are positive for SARS-CoV- 2 is 80 years (median 82, range 0–109, InterQuartile Range - IQR 74–88). The median age of SARSCoV- 2 positive deceased patients is over 30 years higher than that of infected patients (median age: deceased patients 82 years - infected patients 48 years) [data from Istituto Superiore di Sanita updated 18/11/2020]. It is clear that preventive measures are essential to preserve the elderly from the risk of contracting COVID- 19. The psychological impact on the elderly and their relatives of the introduction of “new behaviours” and health safety rules that greatly limit social relationships will be discussed. The medium and long term effects of the various forms of isolation that affect both those living in the family and those who are guests of dedicated facilities concern both emotional and cognitive aspects. The risk is that at the end of the pandemic emergency a large number of elderly people will face increasing levels of non-self-sufficiency and the need for medical and health interventions, which were not necessary in the pre-pandemic phase.

scholarly journals Investigating site-level longitudinal effects of population health interventions: Gay-Straight Alliances and school safety

2019 ◽  
Vol 7 ◽  
pp. 100350 ◽  
Author(s):  
Gu Li ◽  
Amery D. Wu ◽  
Sheila K. Marshall ◽  
Ryan J. Watson ◽  
Jones K. Adjei ◽  
...  
Keyword(s):  
Population Health ◽  
School Safety ◽  
Health Interventions ◽  
Longitudinal Effects

Ovarian Dysfunction in Fetally Irradiated Beagles

1977 ◽  
Vol 35 ◽  
pp. 658-659
Author(s):  
T. M. Seed ◽  
M. H. Sanderson ◽  
D. L. Gutzeit ◽  
T. E. Fritz ◽  
D. V. Tolle ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Low Dose ◽  
Long Term Effects ◽  
Ovarian Dysfunction ◽  
Dose Rates ◽  
Highly Sensitive ◽  
Microscopic Evaluation ◽  
Ovarian Pathology ◽  
Normal Offspring

The developing mammalian fetus is thought to be highly sensitive to ionizing radiation. However, dose, dose-rate relationships are not well established, especially the long term effects of protracted, low-dose exposure. A previous report (1) has indicated that bred beagle bitches exposed to daily doses of 5 to 35 R 60Co gamma rays throughout gestation can produce viable, seemingly normal offspring. Puppies irradiated in utero are distinguishable from controls only by their smaller size, dental abnormalities, and, in adulthood, by their inability to bear young.We report here our preliminary microscopic evaluation of ovarian pathology in young pups continuously irradiated throughout gestation at daily (22 h/day) dose rates of either 0.4, 1.0, 2.5, or 5.0 R/day of gamma rays from an attenuated 60Co source. Pups from non-irradiated bitches served as controls. Experimental animals were evaluated clinically and hematologically (control + 5.0 R/day pups) at regular intervals.

Ultrastructural investigations of MDL 19,660-induced effects on the canine platelet and megakaryocyte

1990 ◽  
Vol 48 (3) ◽  
pp. 374-375
Author(s):  
D.E. Loudy ◽  
J. Sprinkle-Cavallo ◽  
J.T. Yarrington ◽  
F.Y. Thompson ◽  
J.P. Gibson
Keyword(s):  
Antidepressant Drug ◽  
Beagle Dogs ◽  
Long Term Effects ◽  
Short Term ◽  
Platelet Counts ◽  
Toxicological Studies ◽  
Induced Aggregation ◽  
Internal Architecture

Previous short term toxicological studies of one to two weeks duration have demonstrated that MDL 19,660 (5-(4-chlorophenyl)-2,4-dihydro-2,4-dimethyl-3Hl, 2,4-triazole-3-thione), an antidepressant drug, causes a dose-related thrombocytopenia in dogs. Platelet counts started to decline after two days of dosing with 30 mg/kg/day and continued to decrease to their lowest levels by 5-7 days. The loss in platelets was primarily of the small discoid subpopulation. In vitro studies have also indicated that MDL 19,660: does not spontaneously aggregate canine platelets and has moderate antiaggregating properties by inhibiting ADP-induced aggregation. The objectives of the present investigation of MDL 19,660 were to evaluate ultrastructurally long term effects on platelet internal architecture and changes in subpopulations of platelets and megakaryocytes.Nine male and nine female beagle dogs were divided equally into three groups and were administered orally 0, 15, or 30 mg/kg/day of MDL 19,660 for three months. Compared to a control platelet range of 353,000- 452,000/μl, a doserelated thrombocytopenia reached a maximum severity of an average of 135,000/μl for the 15 mg/kg/day dogs after two weeks and 81,000/μl for the 30 mg/kg/day dogs after one week.

Long-Term Effects of Head Lice Tx Unknown

2012 ◽  
Vol 43 (3) ◽  
pp. 42
Author(s):  
MITCHEL L. ZOLER
Keyword(s):  
Head Lice ◽  
Long Term Effects

The response of skin perfusion and of rheological and immunological variables to intravenous prostanoid administration in Raynaud’s phenomenon secondary to collagenosis

VASA ◽  
2005 ◽  
Vol 34 (4) ◽  
pp. 243-249 ◽  
Author(s):  
Drinda ◽  
Neumann ◽  
Pöhlmann ◽  
Vogelsang ◽  
Stein ◽  
...  
Keyword(s):  
Laser Doppler Flowmetry ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Plasma Viscosity ◽  
Laser Doppler ◽  
Erythrocyte Aggregation ◽  
Control Group ◽  
Long Term Effects ◽  
Doppler Flowmetry

Background: Prostanoids are used in the treatment of Raynaud’s phenomenon and acral perfusion disorders secondary to collagenosis. In subjective terms, intravenous administration of these agents produces success in more than 50% of patients. The therapeutic outcome of clinical administration of alprostadil or iloprost may vary from individual to individual. Patients and methods: The following variables were analysed in a cross-over study in 27 patients with collagenosis and Raynaud’s phenomenon: plasma viscosity and erythrocyte aggregation (rheological variables), partial pressure of oxygen and laser Doppler flowmetry in the finger region, and lymphocyte phenotyping and interleukin (IL) determinations (immunological variables). Results: Laser Doppler flowmetry revealed significant differences between patients with secondary Raynaud’s phenomenon and a control group of 25 healthy subjects. Laser Doppler readings did not change significantly as a result of the treatments. Therapy with iloprost produced a reduction in IL-1beta, L-selectin (CD 62 L) and IL-6. Conclusion: The change in immunological variables due to iloprost may explain the long-term effects of prostaglandins in the treatment of Raynaud’s phenomenon. From our results it is not possible to infer any preference for iloprost or alprostadil.

Sign in / Sign up

Export Citation Format

Share Document