Quantifying the effects of operational parameters on the counting efficiency of a condensation particle counter using response surface Design of Experiments (DoE)

2017 ◽  
Vol 106 ◽  
pp. 11-23 ◽  
Author(s):  
Longfei Chen ◽  
Yuegang Ma ◽  
Yuejie Guo ◽  
Cuiqi Zhang ◽  
Zhirong Liang ◽  
...  
Keyword(s):  
Design Of Experiments ◽  
Response Surface ◽  
Counting Efficiency ◽  
Response Surface Design ◽  
Operational Parameters ◽  
Surface Design ◽  
Particle Counter ◽  
Condensation Particle Counter

Rotordynamic Optimization of Fixed Pad Journal Bearings Using Response Surface Design of Experiments

2016 ◽  
Vol 138 (12) ◽  
Author(s):  
Leonardo Urbiola-Soto ◽  
Raymundo Santibañez-Santoscoy ◽  
Marcelo López-Parra ◽  
Alejandro C. Ramírez-Reivich ◽  
Ricardo Yañez-Valdez
Keyword(s):  
Design Of Experiments ◽  
Response Surface ◽  
Critical Speed ◽  
Journal Bearings ◽  
Operating Conditions ◽  
Inlet Temperature ◽  
Response Surface Design ◽  
Surface Design ◽  
Design Variables ◽  
Response Variables

The design process of journal bearings of turbomachines is complex and time-consuming due to the many geometric and physical variables involved. This paper reports on the design of experiments (DOE) and the response surface design of experiments (RSDOE) methods employed on the design of the drive-end and free-end three-lobe journal bearings supporting a centrifugal compressor rotor. The suitability of each technique is discussed. The bearing design variables employed are bearing slenderness ratio, radial clearance, preload, and lubricant inlet temperature. The rotordynamic response variables selected were the critical speed location, the vibrations at critical speed and operating speed for both bearings, and the threshold speed of instability. The use of a nonlinear (quadratic) RSDOE model is justified. An optimization approach combining an SRDOE and rotordynamic finite element modeling is presented. This method leads to arrive to a multivariate model for multi-objective optimization with very few computations. Identification of the dominant design variables and their effects on several response variables allows establishing engineering feasible solutions with focus on manufacturing versus operating conditions tradeoff.

scholarly journals Preclinical optimization of an enterotoxigenic Escherichia coli adjuvanted subunit vaccine using response surface design of experiments

npj Vaccines ◽  
2020 ◽  
Vol 5 (1) ◽  
Author(s):  
David Poncet ◽  
Catherine Hessler ◽  
Hong Liang ◽  
Sylviane Gautheron ◽  
Michelle Sergent ◽  
...  
Keyword(s):  
Immune Responses ◽  
Design Of Experiments ◽  
Response Surface ◽  
Enterotoxigenic Escherichia Coli ◽  
Watery Diarrhoea ◽  
Optimal Dosage ◽  
Response Surface Design ◽  
Surface Design ◽  
Colonization Factor ◽  
Factor Antigen

Abstract Enterotoxigenic E. coli (ETEC) is a leading cause of moderate-to-severe diarrhoea. ETEC colonizes the intestine through fimbrial tip adhesin colonization factors and produces heat-stable and/or heat-labile (LT) toxins, stimulating fluid and electrolyte release leading to watery diarrhoea. We reported that a vaccine containing recombinant colonization factor antigen (CfaEB) targeting fimbrial tip adhesin of the colonization factor antigen I (CFA/I) and an attenuated LT toxoid (dmLT) elicited mucosal and systemic immune responses against both targets. Additionally, the toll-like receptor 4 ligand second-generation lipid adjuvant (TLR4-SLA) induced a potent mucosal response, dependent on adjuvant formulation. However, a combination of vaccine components at their respective individual optimal doses may not achieve the optimal immune profile. We studied a subunit ETEC vaccine prototype in mice using a response surface design of experiments (DoE), consisting of 64 vaccine dose-combinations of CfaEB, dmLT and SLA in four formulations (aqueous, aluminium oxyhydroxide, squalene-in-water stable nanoemulsion [SE] or liposomes containing the saponin Quillaja saponaria-21 [LSQ]). Nine readouts focusing on antibody functionality and plasma cell response were selected to profile the immune response of parenterally administered ETEC vaccine prototype. The data were integrated in a model to identify the optimal dosage of each vaccine component and best formulation. Compared to maximal doses used in mouse models (10 µg CfaEB, 1 µg dmLT and 5 µg SLA), a reduction in the vaccine components up to 37%, 60% and 88% for CfaEB, dmLT and SLA, respectively, maintained or even maximized immune responses, with SE and LSQ the best formulations. The DoE approach can help determine the best vaccine composition with a limited number of experiments and may accelerate development of multi-antigen/component ETEC vaccines.

Defluoridation of drinking water by magnesium and aluminum electrocoagulation in continuous flow-rate: A response surface design.

2021 ◽  
pp. 1-37
Author(s):  
Ana Gabriela Sierra-Sánchez ◽  
Verónica Martínez-Miranda ◽  
Elia Alejandra Teutli-Sequeira ◽  
Ivonne Linares-Hernández ◽  
Guadalupe Vázquez-Mejía ◽  
...  
Keyword(s):  
Drinking Water ◽  
Response Surface ◽  
Flow Rate ◽  
Continuous Flow ◽  
Response Surface Design ◽  
Surface Design

Cleaning and Bacteria Removal in Milking Systems by Alkaline Electrolyzed Oxidizing Water with Response Surface Design

2019 ◽  
Vol 62 (5) ◽  
pp. 1251-1258 ◽  
Author(s):  
Yu Liu ◽  
Chaoyuan Wang ◽  
Zhengxiang Shi ◽  
Baoming Li
Keyword(s):  
Water Treatment ◽  
Response Surface ◽  
Treatment Time ◽  
System Response ◽  
Surface Model ◽  
Response Surface Design ◽  
Surface Design ◽  
Response Surface Models ◽  
Surface Models ◽  
Bacteria Removal

Abstract. A wash cycle using an alkaline solution with a dissolved chemical detergent is a standard clean-in-place (CIP) process for cleaning milking systems. However, long-term chemical use may corrode equipment and create difficulties in wastewater treatment. This study investigated the potential for using alkaline electrolyzed oxidizing (EO) water as an alternative to alkaline chemical detergent for removal of microorganisms and adenosine triphosphate (ATP) on milking system materials. Laboratory trials were performed based on a Box-Behnken response surface design to assess the cleaning effect of alkaline EO water on three materials typically used in milking systems: stainless steel, rubber gasket, and polyvinyl chloride (PVC) hose. Results showed that alkaline EO water treatment was generally enhanced with increased treatment time, temperature, and pH, and their interaction effects were also observed in ATP removal. However, treatment time did not have a dominant role in cleaning PVC hose. Response surface models were developed to reliably predict detected microorganisms and relative light units (RLU) on the three materials after alkaline EO water treatment. Based on the response surface models, the three parameters for alkaline EO water cleaning were optimized as treatment time of 10.0 min, temperature of 61.8°C, and pH of 12, after which microorganisms and RLU were nearly undetectable. Alkaline EO water treatment with the optimized parameters had an equivalent or better cleaning ability compared to the commercial detergent, suggesting its potential as a cleaning and bacteria removal agent for milking systems. Keywords: Alkaline electrolyzed oxidizing water, Cleanliness, Milking system, Response surface model.

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