scholarly journals Base change along the Frobenius endomorphism and the Gorenstein property

Author(s):  
Pinches Dirnfeld
Author(s):  
Kâzım Büyükboduk ◽  
Antonio Lei

AbstractThis article is a continuation of our previous work [7] on the Iwasawa theory of an elliptic modular form over an imaginary quadratic field $K$, where the modular form in question was assumed to be ordinary at a fixed odd prime $p$. We formulate integral Iwasawa main conjectures at non-ordinary primes $p$ for suitable twists of the base change of a newform $f$ to an imaginary quadratic field $K$ where $p$ splits, over the cyclotomic ${\mathbb{Z}}_p$-extension, the anticyclotomic ${\mathbb{Z}}_p$-extensions (in both the definite and the indefinite cases) as well as the ${\mathbb{Z}}_p^2$-extension of $K$. In order to do so, we define Kobayashi–Sprung-style signed Coleman maps, which we use to introduce doubly signed Selmer groups. In the same spirit, we construct signed (integral) Beilinson–Flach elements (out of the collection of unbounded Beilinson–Flach elements of Loeffler–Zerbes), which we use to define doubly signed $p$-adic $L$-functions. The main conjecture then relates these two sets of objects. Furthermore, we show that the integral Beilinson–Flach elements form a locally restricted Euler system, which in turn allow us to deduce (under certain technical assumptions) one inclusion in each one of the four main conjectures we formulate here (which may be turned into equalities in favorable circumstances).


Genetics ◽  
2004 ◽  
Vol 166 (2) ◽  
pp. 661-668
Author(s):  
Mandy Kim ◽  
Erika Wolff ◽  
Tiffany Huang ◽  
Lilit Garibyan ◽  
Ashlee M Earl ◽  
...  

Abstract We have applied a genetic system for analyzing mutations in Escherichia coli to Deinococcus radiodurans, an extremeophile with an astonishingly high resistance to UV- and ionizing-radiation-induced mutagenesis. Taking advantage of the conservation of the β-subunit of RNA polymerase among most prokaryotes, we derived again in D. radiodurans the rpoB/Rif r system that we developed in E. coli to monitor base substitutions, defining 33 base change substitutions at 22 different base pairs. We sequenced >250 mutations leading to Rif r in D. radiodurans derived spontaneously in wild-type and uvrD (mismatch-repair-deficient) backgrounds and after treatment with N-methyl-N′-nitro-N-nitrosoguanidine (NTG) and 5-azacytidine (5AZ). The specificities of NTG and 5AZ in D. radiodurans are the same as those found for E. coli and other organisms. There are prominent base substitution hotspots in rpoB in both D. radiodurans and E. coli. In several cases these are at different points in each organism, even though the DNA sequences surrounding the hotspots and their corresponding sites are very similar in both D. radiodurans and E. coli. In one case the hotspots occur at the same site in both organisms.


Author(s):  
Alice Garbagnati

Abstract We discuss the birational geometry and the Kodaira dimension of certain varieties previously constructed by Schreieder, proving that in any dimension they admit an elliptic fibration and they are not of general type. The $l$-dimensional variety $Y_{(n)}^{(l)}$, which is the quotient of the product of a certain curve $C_{(n)}$ by itself $l$ times by a group $G\simeq \left ({\mathbb{Z}}/n{\mathbb{Z}}\right )^{l-1}$ of automorphisms, was constructed by Schreieder to obtain varieties with prescribed Hodge numbers. If $n=3^c$ Schreieder constructed an explicit smooth birational model of it, and Flapan proved that the Kodaira dimension of this smooth model is 1, if $c>1$; if $l=2$ it is a modular elliptic surface; if $l=3$ it admits a fibration in K3 surfaces. In this paper we generalize these results: without any assumption on $n$ and $l$ we prove that $Y_{(n)}^{(l)}$ admits many elliptic fibrations and its Kodaira dimension is at most 1. Moreover, if $l=2$, its minimal resolution is a modular elliptic surface, obtained by a base change of order $n$ on a specific extremal rational elliptic surface; if $l\geq 3$ it has a birational model that admits a fibration in K3 surfaces and a fibration in $(l-1)$-dimensional varieties of Kodaira dimension at most 0.


Animals ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 668
Author(s):  
Zhi-gang Niu ◽  
Jin Qin ◽  
Yao Jiang ◽  
Xiang-Dong Ding ◽  
Yu-gong Ding ◽  
...  

The Bone Morphogenetic Protein 15 (BMP15) gene is known to have multiple single-nucleotide polymorphism sites associated with sheep fecundity. This study used gene sequence analysis and mutation detection assays for BMP15 by using 205 blood samples of ewes with known lambing records. Sequence analysis showed that mutation B1 missed the CTT base in exon 1 at positions 28–30, leading to a leucine deletion in the BMP15 protein. Litter size of ewes differed significantly between BB and B+ genotypes of B1 (p < 0.05); however, the differences between wild genotype (++) and homozygous (BB) or wild genotype (++) and heterozygous (B+) were not significant (p > 0.05). Another mutation, T755C, is a T-to-C base change at position 755 of exon 2, resulting in leucine replacement by proline at this position of the BMP15 protein (p.L252P). Two genotypes were identified in the flock: heterozygous (E+) and wild-type genotype (++). Ewes with heterozygous (E+) p.L252P had significantly larger litter sizes than those with the wild-type genotype (p < 0.05). Comprehensive analysis suggests that p.L252P is a mutation that affects fecundity in Cele black sheep.


2005 ◽  
Vol 33 (11) ◽  
pp. 3977-3987 ◽  
Author(s):  
Massoud Tousi ◽  
Siamak Yassemi
Keyword(s):  

2019 ◽  
Vol 12 (2) ◽  
pp. 205979911986328
Author(s):  
Hester Nienaber

Management theory and practice are characterised by the ‘theory–practice gap’. A way of addressing this divide is to engage in reflective practice, in this instance, a creative auto/biography. This different way of presenting an old issue demonstrates how the original teachings of the management pioneers remain relevant today. The central issues are the purpose of the organisation and the role of both leadership and employees in unlocking human competence in pursuit of organisational performance. The concepts ‘autonomy’ and ‘control’ transpired as crucial, which could easily be misunderstood or misapplied. This personal reflection presents evidence on which to base change, enhancing the well-being of employees, societies and the profit of organisations. This article contributes to knowledge by making inaccessible knowledge, accessible and inclusive, and the expectation that the meaning emanating from this reflection will result in the management audience to reconsider management, advancing management science and benefitting society at large.


2014 ◽  
Vol 398 ◽  
pp. 131-155 ◽  
Author(s):  
Mrinal Kanti Das ◽  
Md. Ali Zinna
Keyword(s):  

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yavor K. Bozhilov ◽  
Damien J. Downes ◽  
Jelena Telenius ◽  
A. Marieke Oudelaar ◽  
Emmanuel N. Olivier ◽  
...  

AbstractMany single nucleotide variants (SNVs) associated with human traits and genetic diseases are thought to alter the activity of existing regulatory elements. Some SNVs may also create entirely new regulatory elements which change gene expression, but the mechanism by which they do so is largely unknown. Here we show that a single base change in an otherwise unremarkable region of the human α-globin cluster creates an entirely new promoter and an associated unidirectional transcript. This SNV downregulates α-globin expression causing α-thalassaemia. Of note, the new promoter lying between the α-globin genes and their associated super-enhancer disrupts their interaction in an orientation-dependent manner. Together these observations show how both the order and orientation of the fundamental elements of the genome determine patterns of gene expression and support the concept that active genes may act to disrupt enhancer-promoter interactions in mammals as in Drosophila. Finally, these findings should prompt others to fully evaluate SNVs lying outside of known regulatory elements as causing changes in gene expression by creating new regulatory elements.


2011 ◽  
Vol 78 (2) ◽  
pp. 334-345 ◽  
Author(s):  
Tsvetan R. Bachvaroff ◽  
Sunju Kim ◽  
Laure Guillou ◽  
Charles F. Delwiche ◽  
D. Wayne Coats

ABSTRACTThe genusEuduboscquellais one of a few described genera within the syndinean dinoflagellates, an enigmatic lineage with abundant diversity in marine environmental clone libraries based on small subunit (SSU) rRNA. The region composed of the SSU through to the partial large subunit (LSU) rRNA was determined from 40 individual tintinnid ciliate loricae infected withEuduboscquellasampled from eight surface water sites in the Northern Hemisphere, producing seven distinct SSU sequences. The corresponding host SSU rRNA region was also amplified from eight host species. The SSU tree ofEuduboscquellaand syndinean group I sequences from environmental clones had seven well-supported clades and one poorly supported clade across data sets from 57 to 692 total sequences. The genusEuduboscquellaconsistently formed a supported monophyletic clade within a single subclade of group I sequences. For most parasites with identical SSU sequences, the more variable internal transcribed spacer (ITS) to LSU rRNA regions were polymorphic at 3 to 10 sites. However, inE. cachonithere was variation between ITS to LSU copies at up to 20 sites within an individual, while in a parasite ofTintinnopsisspp., variation between different individuals ranged up to 19 polymorphic sites. However, applying the compensatory base change model to the ITS2 sequences suggested no compensatory changes within or between individuals with the same SSU sequence, while one to four compensatory changes between individuals with similar but not identical SSU sequences were found. Comparisons between host and parasite phylogenies do not suggest a simple pattern of host or parasite specificity.


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