O4-04-03: Amnestic mild cognitive impairment in a referral population-a non-progressing subgroup exists on long-term follow-up

Background: Amyloid PET allows for the assessment of amyloid β status in the brain, distinguishing true Alzheimer’s disease from Alzheimer’s disease-mimicking conditions. Around 15–20% of patients with clinically probable Alzheimer’s disease have been found to have no significant Alzheimer’s pathology on amyloid PET. However, a limited number of studies had been conducted this subpopulation in terms of clinical progression. Objective: We investigated the risk factors that could affect the progression to dementia in patients with amyloid-negative amnestic mild cognitive impairment (MCI). Methods: This study was a single-institutional, retrospective cohort study of patients over the age of 50 with amyloidnegative amnestic MCI who visited the memory clinic of Asan Medical Center with a follow-up period of more than 36 months. All participants underwent brain magnetic resonance imaging (MRI), detailed neuropsychological testing, and fluorine-18[F18]-florbetaben amyloid PET. Results: During the follow-up period, 39 of 107 patients progressed to dementia from amnestic MCI. In comparison with the stationary group, the progressed group had a more severe impairment in verbal and visual episodic memory function and hippocampal atrophy, which showed an Alzheimer’s disease-like pattern despite the lack of evidence for significant Alzheimer’s disease pathology. Voxel-based morphometric MRI analysis revealed that the progressed group had a reduced gray matter volume in the bilateral cerebellar cortices, right temporal cortex, and bilateral insular cortices. Conclusion: Considering the lack of evidence of amyloid pathology, clinical progression of these subpopulation may be caused by other neuropathologies such as TDP-43, abnormal tau or alpha synuclein that lead to neurodegeneration independent of amyloid-driven pathway. Further prospective studies incorporating biomarkers of Alzheimer’s diseasemimicking dementia are warranted.

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332 - Electroconvulsive therapy in older adults with major depression was not associated with cognitive decline during a 15-year follow-up

International Psychogeriatrics ◽

10.1017/s104161022000232x ◽

2020 ◽

Vol 32 (S1) ◽

pp. 91-91

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Major Depression ◽

Cognitive Decline ◽

Electroconvulsive Therapy ◽

Antidepressant Treatment ◽

Community Sample ◽

Control Group

AUTHORS:Kerstin Johansson, Karolina Thömkvist, Ingmar Skoog and Sacuiu SF* (*presenter)OBJECTIVE:To determine the effects of electroconvulsive therapy (ECT) in major depression in relation to the development of dementia during long-term follow-up.METHOD:In an observational clinical prospective study of consecutive patients 70 years and older diagnosed with major depression at baseline 2000-2004 (n=1090), who were free of dementia and received antidepressant treatment, with or without ECT, we sought to determine if cognitive decline (mild cognitive impairment and dementia) during 15 -year follow-up was associated with receiving ECT at baseline. The control group was selected among the participants in the Gothenburg H70 Birth Cohort Studies matched by age group and sex 1:1.RESULTS:Among patients with affective syndromes 7% received ECT. During follow-up, 157 patients were diagnosed with dementia, equal proportions among those who received ECT (14.5%) and those who did not receive ECT (14.5%). The relation between ECT and cognitive decline remained non-significant irrespective antidepressive medication or presence of mild cognitive impairment at baseline.CONCLUSION:Preliminary results indicate that ECT was not associated with the development of cognitive decline in the long-term in a hospital-based cohort of 70+ year-olds. The results remain to verify against controls from a representative community sample.

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P4-308: [18F]FLUTEMETAMOL AMYLOID PET IMAGING: OUTCOME OF A PHASE III STUDY IN SUBJECTS WITH AMNESTIC MILD COGNITIVE IMPAIRMENT AFTER A 3-YEAR FOLLOW-UP

Alzheimer s & Dementia ◽

10.1016/j.jalz.2014.07.079 ◽

2014 ◽

Vol 10 ◽

pp. P898-P898 ◽

Cited By ~ 2

Author(s):

David A. Wolk ◽

Ranjan Duara ◽

Carl Sadowsky

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Pet Imaging ◽

Amnestic Mild Cognitive Impairment ◽

Phase Iii ◽

Amyloid Pet ◽

Phase Iii Study ◽

Amyloid Pet Imaging

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P2-019: THE LONG-TERM EFFECTS OF ACUPUNCTURE ON HIPPOCAMPUS FUNCTIONAL CONNECTIVITY IN AMNESTIC MILD COGNITIVE IMPAIRMENT: A LONGITUDINAL FMRI STUDY

Alzheimer s & Dementia ◽

10.1016/j.jalz.2019.06.1241 ◽

2019 ◽

Vol 15 ◽

pp. P577-P577

Author(s):

Hui Li ◽

Kuncheng Li

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Functional Connectivity ◽

Amnestic Mild Cognitive Impairment ◽

Long Term Effects ◽

Fmri Study

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Benefits of training working memory in amnestic mild cognitive impairment: specific and transfer effects

International Psychogeriatrics ◽

10.1017/s1041610212002177 ◽

2012 ◽

Vol 25 (4) ◽

pp. 617-626 ◽

Cited By ~ 42

Author(s):

Barbara Carretti ◽

Erika Borella ◽

Silvia Fostinelli ◽

Michela Zavagnin

Keyword(s):

Working Memory ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Fluid Intelligence ◽

Amnestic Mild Cognitive Impairment ◽

Control Group ◽

Long Term Memory ◽

Transfer Effects ◽

Memory Problems

ABSTRACTBackground:A growing number of studies are attempting to understand how effective cognitive interventions may be for patients with amnestic mild cognitive impairment (aMCI), particularly in relation to their memory problems.Methods:The present study aimed to explore the benefits of a working memory (WM) training program in aMCI patients. Patients (N= 20) were randomly assigned to two training programs: the experimental group practiced with a verbal WM task, while the active control group conducted educational activities on memory.Results:Results showed that the aMCI patients completing the WM training obtained specific gains in the task trained with some transfer effects on other WM measures (visuospatial WM) and on processes involved in or related to WM, e.g. fluid intelligence (the Cattell test) and long-term memory. This was not the case for the aMCI control group, who experienced only a very limited improvement.Conclusion:This pilot study suggests that WM training could be a valuable method for improving cognitive performance in aMCI patients, possibly delaying the onset of Alzheimer's disease.

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P1-464: Episodic long-term memory as a predictor of change from retrieval to storage memory profile in amnestic mild cognitive impairment

Alzheimer s & Dementia ◽

10.1016/j.jalz.2011.05.746 ◽

2011 ◽

Vol 7 ◽

pp. S262-S262

Author(s):

Emma Rodriguez-Noriega ◽

Mikel Olabarrieta ◽

Francesc Pujadas ◽

Marta Ibarria ◽

Diana Liebana ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Amnestic Mild Cognitive Impairment ◽

Long Term Memory ◽

Term Memory

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Cognitive impairment predicts poststroke death in long-term follow-up

Journal of Neurology Neurosurgery & Psychiatry ◽

10.1136/jnnp.2009.174573 ◽

2009 ◽

Vol 80 (11) ◽

pp. 1230-1235 ◽

Cited By ~ 69

Author(s):

N K J Oksala ◽

H Jokinen ◽

S Melkas ◽

A Oksala ◽

T Pohjasvaara ◽

...

Keyword(s):

Cognitive Impairment ◽

Long Term Follow Up

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180 Cognitive disorders in takotsubo syndrome: incidence, short, and long term outcome. Results from a prospective multi-centre registry

European Heart Journal Supplements ◽

10.1093/eurheartj/suab142.025 ◽

2021 ◽

Vol 23 (Supplement_G) ◽

Author(s):

Adriana Mallardi ◽

Francesco Santoro ◽

Alessandra Leopizzi ◽

Enrica Vitale ◽

Massimo Iacoviello ◽

...

Keyword(s):

Cognitive Impairment ◽

Old Age ◽

Neurological Disorders ◽

Left Ventricular ◽

Left Ventricular Ejection ◽

Takotsubo Syndrome ◽

Long Term Follow Up ◽

Short And Long Term

Abstract Aims Takotsubo syndrome (TTS) is an acute and reversible left ventricular dysfunction, whose pathophysiological mechanisms are not completely known. There are evidence suggesting a possible link between neurological disease and TTS. Aim of the study was to evaluate incidence and prognostic value of cognitive neurological disorders among TTS patients. Methods and results 379 consecutive patients were enrolled in a prospective multicentre registry. History, clinical features, echocardiographic parameters, in-hospital complications and long-term Follow-up events of all patients were recorded. Cognitive neurological disorders included Alzheimer disease, old age dementia and cognitive impairment for other causes. Prevalence of cognitive neurological disorders among TTS patients was 5.5% (num = 21). Among this subset of patients 48% (num = 10) had Alzheimer syndrome, 24% (num = 5) old age dementia and 28% (num = 6) cognitive impairment for other causes. Compared to the control group, these patients were older (81 ± 5 vs. 71 ± 12, P = 0.01) and predominantly men (24% vs. 9%, P = 0.01). No differences in term of cardiovascular risk factors and left ventricular ejection fraction at admission and discharge were found among the two groups. TTS patients with cognitive neurological disorders experienced higher rate of in-hospital complications (62% vs. 28%, P = 0.01), that were mainly driven by higher rate of pulmonary oedema (14% vs. 9%, P = 0.01), cardiogenic shock (29% vs. 8%, P = 0.01), death (24% vs. 4% P = 0.01), ischaemic stroke (10% vs. 4%, P = 0.01), and left ventricular thrombi (10% vs. 3%, P = 0.01). At long-term follow-up patients with cognitive neurological disorders when compared to those without, experienced higher rate of mayor cardiovascular events (48% vs. 16%, P = 0.01), cardiovascular re-hospitalization (14% vs. 10%, P = 0.01) and death (43% vs. 9%, P = 0.01). Conclusions TTS patients with cognitive neurological disorders had an increased risk of in and out of hospital mayor cardiac adverse events and mortality at short and long-term follow-up.

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