S1-01-03: Are metabolic risk factors also risk factors for Alzheimer's disease or vascular dementia?

There is little doubt that dementia is a very common cause of disability and dependency in our society. Since dementia of whatever type is usually more common with increasing age, then as population demographics change, so will the prevalence of dementia. Dementia is a generic term and the objective for clinicians, once dementia is suspected, is to attempt to define the cause. Alzheimer's disease is the most common cause of dementia, and in most centres vascular dementia would feature as the next most common aetiology. In some centres, Lewy body dementia is the second most common cause. Mixed Alzheimer's disease and vascular dementia would also feature high on the list at most centres.

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Use of aripiprazole for psychosis and agitation in dementia

International Psychogeriatrics ◽

10.1017/s1041610205002541 ◽

2005 ◽

Vol 18 (2) ◽

pp. 335-340 ◽

Cited By ~ 5

Author(s):

Jerson Laks ◽

Roberto Miotto ◽

Valeska Marinho ◽

Eliasz Engelhardt

Keyword(s):

Risk Factors ◽

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Vascular Dementia ◽

Elderly Woman ◽

Marked Decrease ◽

Disease Risk ◽

Complete Recovery ◽

Neuropsychiatric Inventory

We report the case of an elderly woman with Alzheimer's disease, risk factors for vascular dementia, and atrium-ventricular blockade, who presented with severe agitation and psychosis. She was treated with aripiprazole and assessed with the Neuropsychiatric Inventory (NPI) over the course of 14 weeks. NPI scores showed a marked decrease in psychosis and agitation at week 4, and complete recovery at week 14, except for depression.

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The Role of Cardiovascular Risk Factors in Alzheimer's Disease

CNS Spectrums ◽

10.1017/s109285290001926x ◽

2003 ◽

Vol 8 (11) ◽

pp. 824-831 ◽

Cited By ~ 13

Author(s):

Ramit Ravona-Springer ◽

Michael Davidson ◽

Shlomo Noy

Keyword(s):

Risk Factors ◽

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cardiovascular Risk ◽

Vascular Dementia ◽

Cardiovascular Risk Factors ◽

Treatment Strategies ◽

Mechanisms Of Action ◽

Clinical Imaging

ABSTRACTThe distinction between Alzheimer's disease and vascular dementia, the two most common types of dementia, has been undermined by recent advances in epidemiologic, clinical, imaging, and neuropathological studies. Cardiovascular risk factors, traditionally regarded as distinguishing criteria between the two entities, have been shown to be associated with both AD and vascular dementia. In this article, we propose mechanisms of action of cardiovascular risk factors in AD, suggest possible explanations for the overlap with vascular dementia and discuss the implications this might have on future differential diagnosis, research, and treatment strategies.

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Metabolic Risk Factors of Alzheimer’s Disease, Dementia with Lewy Bodies, and Normal Elderly: A Population-Based Study

Behavioural Neurology ◽

10.1155/2018/8312346 ◽

2018 ◽

Vol 2018 ◽

pp. 1-8 ◽

Cited By ~ 2

Author(s):

Chih-Kuang Cheng ◽

Yu-Chien Tsao ◽

Yuan-Chih Su ◽

Fung-Chang Sung ◽

Hsu-Chih Tai ◽

...

Keyword(s):

Risk Factors ◽

Alzheimer’S Disease ◽

Ischemic Stroke ◽

Lower Risk ◽

Dementia With Lewy Bodies ◽

Lewy Bodies ◽

Population Based ◽

Metabolic Risk Factors ◽

Metabolic Risk ◽

Population Based Study

Background. Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) share many risk factors. Evidence suggests that metabolic risk factors are important to AD; however, their association with DLB is unclear. The risk of cardiovascular diseases (CVD) associated with AD and DLB is also uncertain. Thus, this nationwide, population-based study was designed to evaluate the metabolic and CVD risks in AD and DLB. Materials and Methods. Data were obtained from the Taiwan National Health Insurance Research Database. AD patients, DLB patients, and normal control (NC) individuals from 1996 to 2013 were enrolled for risk assessment. Results. In total, 7544 NC individuals, 1324 AD patients, and 562 DLB patients were enrolled. Participants with one or more metabolic risk factors had significantly higher odds of AD or DLB. No significant differences in metabolic risk factors were observed between DLB and AD patients. AD patients had a lower risk of CVD (aHR = 0.67, 95% CI = 0.59–0.76, p value < 0.001) and coronary artery disease (CAD) (aHR = 0.59, 95% CI = 0.51–0.69, p value < 0.001) than NC. DLB patients had a higher risk of ischemic stroke (aHR = 2.27, 95% CI = 1.68–3.06, p value < 0.001) than NC. Conclusion. Metabolic risk factors are important in AD and DLB. Patients with AD might have a lower risk of CAD and ischemic strokes. Patients with DLB might have a higher risk of ischemic stroke.

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