Metabolic Risk Factors of Alzheimer’s Disease, Dementia with Lewy Bodies, and Normal Elderly: A Population-Based Study

Background. Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) share many risk factors. Evidence suggests that metabolic risk factors are important to AD; however, their association with DLB is unclear. The risk of cardiovascular diseases (CVD) associated with AD and DLB is also uncertain. Thus, this nationwide, population-based study was designed to evaluate the metabolic and CVD risks in AD and DLB. Materials and Methods. Data were obtained from the Taiwan National Health Insurance Research Database. AD patients, DLB patients, and normal control (NC) individuals from 1996 to 2013 were enrolled for risk assessment. Results. In total, 7544 NC individuals, 1324 AD patients, and 562 DLB patients were enrolled. Participants with one or more metabolic risk factors had significantly higher odds of AD or DLB. No significant differences in metabolic risk factors were observed between DLB and AD patients. AD patients had a lower risk of CVD (aHR = 0.67, 95% CI = 0.59–0.76, p value < 0.001) and coronary artery disease (CAD) (aHR = 0.59, 95% CI = 0.51–0.69, p value < 0.001) than NC. DLB patients had a higher risk of ischemic stroke (aHR = 2.27, 95% CI = 1.68–3.06, p value < 0.001) than NC. Conclusion. Metabolic risk factors are important in AD and DLB. Patients with AD might have a lower risk of CAD and ischemic strokes. Patients with DLB might have a higher risk of ischemic stroke.

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High-normal blood pressure is associated with a cluster of cardiovascular and metabolic risk factors: a population-based study

Journal of Hypertension ◽

10.1097/hjh.0b013e328317a7bb ◽

2009 ◽

Vol 27 (1) ◽

pp. 102-108 ◽

Cited By ~ 21

Author(s):

Simona Bo ◽

Roberto Gambino ◽

Luigi Gentile ◽

Gianfranco Pagano ◽

Rosalba Rosato ◽

...

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Population Based ◽

Metabolic Risk Factors ◽

Normal Blood ◽

Metabolic Risk ◽

Normal Blood Pressure ◽

Population Based Study

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Abstract #1060 The Prevalence of Subclinical Hypothyroidism and its Association with Cardio Metabolic Risk Factors in North-Western Nigeria. A Population-Based Study.

Endocrine Practice ◽

10.1016/s1530-891x(20)47425-7 ◽

2018 ◽

Vol 24 ◽

pp. 249-250

Author(s):

Salisu Muazu ◽

Haliru Ibrahim ◽

Hauwa Bako ◽

Ahmad Bello

Keyword(s):

Risk Factors ◽

Subclinical Hypothyroidism ◽

Population Based ◽

Metabolic Risk Factors ◽

Metabolic Risk ◽

Population Based Study ◽

North Western

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Prevalence of hepatic steatosis as assessed by controlled attenuation parameter (CAP) in subjects with metabolic risk factors in primary care. A population-based study

PLoS ONE ◽

10.1371/journal.pone.0200656 ◽

2018 ◽

Vol 13 (9) ◽

pp. e0200656 ◽

Cited By ~ 6

Author(s):

Núria Fabrellas ◽

Rosario Hernández ◽

Isabel Graupera ◽

Elsa Solà ◽

Pilar Ramos ◽

...

Keyword(s):

Risk Factors ◽

Primary Care ◽

Hepatic Steatosis ◽

Population Based ◽

Metabolic Risk Factors ◽

Metabolic Risk ◽

Controlled Attenuation Parameter ◽

Population Based Study ◽

Attenuation Parameter

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Trend of Cardio-Metabolic Risk Factors in Polycystic Ovary Syndrome: A Population-Based Prospective Cohort Study

PLoS ONE ◽

10.1371/journal.pone.0137609 ◽

2015 ◽

Vol 10 (9) ◽

pp. e0137609 ◽

Cited By ~ 24

Author(s):

Fahimeh Ramezani Tehrani ◽

Seyed Ali Montazeri ◽

Farhad Hosseinpanah ◽

Leila Cheraghi ◽

Hadi Erfani ◽

...

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Polycystic Ovary Syndrome ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Polycystic Ovary ◽

Population Based ◽

Metabolic Risk Factors ◽

Metabolic Risk ◽

Ovary Syndrome

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Association between homocysteine and white matter hyperintensities in asymptomatic intracranial arterial stenosis: results from a population-based study

10.21203/rs.2.16135/v1 ◽

2019 ◽

Author(s):

Hao Yin ◽

Xiang Wang ◽

Yuan-yuan Zhao ◽

Xiao-kang Ji ◽

Shao-wei Sang ◽

...

Keyword(s):

Risk Factors ◽

Ischemic Stroke ◽

White Matter ◽

Magnetic Resonance ◽

White Matter Hyperintensities ◽

Population Based ◽

Arterial Stenosis ◽

Chinese People ◽

Intracranial Arterial Stenosis ◽

Population Based Study

Abstract Background: Although homocysteine (Hcy) and white matter hyperintensities (WMH) have been proven to be correlated with increased risks of ischemic stroke, there have been few studies addressing the association between serum Hcy and WMH in a population with asymptomatic intracranial arterial stenosis (aICAS). Thus, the aim of the present study is to describe the association between Hcy and WMH in rural-dwelling Chinese people with aICAS. Methods: In this study, 150 participants diagnosed as aICAS by magnetic resonance angiography were recruited from the Kongcun Town Study, which was a population-based study aimed to investigate the prevalence of aICAS in general population aged 40 to 90 years old, free of ischemic stroke history, and living in the Kongcun town, Pingyin county, Shandong, China. Data on demographics, risk factors, and serum Hcy levels were collected via interview, clinical examination, and laboratory tests. The WMH volumes were calculated through the lesion segmentation tool system for the Statistical Parametric Mapping package based on magnetic resonance imaging. The association between Hcy and WMH volume was analyzed using both linear and logistic regression analysis. Results: After adjusting for all confounders, high Hcy (HHcy) (serum Hcy ≥15umol/L) was significantly associated with severe WMH (the highest quartile in WMH volume) (OR: 2.972, 95%CI: 1.017-7.979, P <0.05). However, with changing of WMH volumes, only trends towards association with HHcy were observed in all 3 models (P values only slightly exceeded 0.05). After being stratified by age, sex, or ever smoking, the association between HHcy and WMH became more significant in participants who were ≥60 years old, male, or ever smoker. Conclusions: HHcy is associated with severe WMH in rural-dwelling Chinese people with aICAS, especially in participants ≥60 years old, male participants, or ever smokers, indicating these may be risk factors that contribute to the association between HHcy and severe WMH.

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Tomato and lycopene consumption is inversely associated with total and cause-specific mortality: a population-based cohort study, on behalf of the International Lipid Expert Panel (ILEP)

British Journal Of Nutrition ◽

10.1017/s0007114519002150 ◽

2019 ◽

Vol 124 (12) ◽

pp. 1303-1310 ◽

Cited By ~ 3

Author(s):

Mohsen Mazidi ◽

Niki Katsiki ◽

Elena S. George ◽

Maciej Banach

Keyword(s):

Risk Factors ◽

Population Based ◽

Metabolic Risk Factors ◽

Favourable Effect ◽

Metabolic Risk ◽

Total Risk ◽

Reactive Protein ◽

Specific Mortality ◽

Cox Proportional Hazard Regression ◽

Long Term Impact

AbstractNo data exist on the associations of dietary tomato and lycopene consumption with total and cause-specific mortality. Using the National Health and Nutrition Examination Surveys 1999–2010, we evaluted the long-term impact of tomato and lycopene intake on total and cause-specific (CHD and cerebrovascular disease) mortality. We also assessed the changes in cardio-metabolic risk factors according to tomato and lycopene intake. Vital status to 31 December 2011 was ascertained. Cox proportional hazard regression models (followed by propensity score matching) were used to investigate the link between tomato and lycopene consumption total, CHD and cerebrovascular mortality. Among the 23 935 participants included (mean age = 47·6 years, 48·8 % men), 3403 deaths occurred during 76·4 months of follow-up. Tomato intake was inversely associated with total (risk ratio (RR) 0·86, 95 % CI 0·81, 0·92), CHD (RR 0·76, 95 % CI 0·70, 0·85) and cerebrovascular (RR 0·70, 95 % CI 0·62, 0·81) mortality. Similar inverse associations were found between lycopene consumption, total (RR 0·76, 95 % CI 0·72, 0·81), CHD (RR 0·73, 95 % CI 0·65, 0·83) and cerebrovascular (RR 0·71, 95 % CI 0·65, 0·78) mortality; these associations were independent of anthropometric, clinical and nutritional parameters. Age and obesity did not affect the association of tomato and lycopene consumption with total, CHD and cerebrovascular mortality. C-reactive protein significantly moderated the link between lycopene and tomato intake with total, CHD and cerebrovascular mortality. ANCOVA showed that participants with a higher tomato and lycopene consumption had a more cardio-protective profile compared with those with a lower intake. Our results highlighted the favourable effect of tomato and lycopene intake on total and cause-specific mortality as well as on cardio-metabolic risk factors. These findings should be taken into consideration for public health strategies.

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