[P3-562]: HIGH PREVALENCE OF VASCULAR AND METABOLIC RISK FACTORS AMONG DOWN SYNDROME PATIENTS WITH ALZHEIMER's DISEASE: A SURVEY REPORT OF THE NATIONAL DOWN SYNDROME REGISTRY (DS-CONNECT)

Background. Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) share many risk factors. Evidence suggests that metabolic risk factors are important to AD; however, their association with DLB is unclear. The risk of cardiovascular diseases (CVD) associated with AD and DLB is also uncertain. Thus, this nationwide, population-based study was designed to evaluate the metabolic and CVD risks in AD and DLB. Materials and Methods. Data were obtained from the Taiwan National Health Insurance Research Database. AD patients, DLB patients, and normal control (NC) individuals from 1996 to 2013 were enrolled for risk assessment. Results. In total, 7544 NC individuals, 1324 AD patients, and 562 DLB patients were enrolled. Participants with one or more metabolic risk factors had significantly higher odds of AD or DLB. No significant differences in metabolic risk factors were observed between DLB and AD patients. AD patients had a lower risk of CVD (aHR = 0.67, 95% CI = 0.59–0.76, p value < 0.001) and coronary artery disease (CAD) (aHR = 0.59, 95% CI = 0.51–0.69, p value < 0.001) than NC. DLB patients had a higher risk of ischemic stroke (aHR = 2.27, 95% CI = 1.68–3.06, p value < 0.001) than NC. Conclusion. Metabolic risk factors are important in AD and DLB. Patients with AD might have a lower risk of CAD and ischemic strokes. Patients with DLB might have a higher risk of ischemic stroke.

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High prevalence of cardio-metabolic risk factors among adolescents with intellectual disability

Acta Paediatrica ◽

10.1111/j.1651-2227.2008.01197.x ◽

2009 ◽

Vol 98 (5) ◽

pp. 853-859 ◽

Cited By ~ 35

Author(s):

Eva Flygare Wallén ◽

Maria Müllersdorf ◽

Kyllike Christensson ◽

Gunilla Malm ◽

Örjan Ekblom ◽

...

Keyword(s):

Risk Factors ◽

Intellectual Disability ◽

Metabolic Risk Factors ◽

Metabolic Risk ◽

High Prevalence

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The prevalence of metabolic risk factors of atherosclerotic cardiovascular disease in Williams syndrome, Prader–Willi syndrome, and Down syndrome

Journal of Intellectual & Developmental Disability ◽

10.3109/13668250.2016.1167845 ◽

2016 ◽

Vol 41 (3) ◽

pp. 187-196 ◽

Cited By ~ 5

Author(s):

Marianne Nordstrøm ◽

Benedicte Paus ◽

Kjetil Retterstøl ◽

Svein O. Kolset

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Down Syndrome ◽

Williams Syndrome ◽

Metabolic Risk Factors ◽

Atherosclerotic Cardiovascular Disease ◽

Prader Willi Syndrome ◽

Metabolic Risk

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Physical activity, BMI and metabolic risk in Portuguese adolescents

Brazilian Journal of Kinanthropometry and Human Performance ◽

10.5007/1980-0037.2016v18n1p103 ◽

2016 ◽

Vol 18 (1) ◽

pp. 103 ◽

Cited By ~ 3

Author(s):

Fernanda Karina dos Santos ◽

Thayse Natacha Queiroz Ferreira Gomes ◽

Michele Caroline de Souza ◽

Raquel Nichele Chaves ◽

Daniel Monteiro de Vilhena Santos ◽

...

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Blood Pressure ◽

Hdl Cholesterol ◽

Normal Weight ◽

Metabolic Risk Factors ◽

Metabolic Risk ◽

Positive Role ◽

High Prevalence ◽

Portuguese Adolescents

DOI: http://dx.doi.org/10.5007/1980-0037.2016v18n1p103 It has been reported, in the last decades, a significant decrease in physical activity (PA) levels, with a consequent increase in obesity and metabolic risk factors among youth. The aims of this study were to describe PA levels, the prevalence of overweight/obesity and metabolic risk factors, and to examine the association between PA and body mass index (BMI) with metabolic risk among Portuguese youth. The sample comprises 212 Portuguese adolescents (12-16 years old). Height and weight were measured. PA was estimated with the Bouchard questionnaire (3 days recall), as well as with the use of a pedometer (used for 5 consecutive days). Metabolic risk factors comprised fasting glucose, triglycerides, HDL-cholesterol, systolic blood pressure and waist circumference. Subjects were classified as normal weight, overweight or obese according to BMI; the maturational status was indirectly estimated with the maturity offset procedure. A continuous metabolic risk score was computed (zMR) and PA values were divided into tertiles. Qui-square test, t-test and ANOVA were used in statistical analyses. SPSS 18.0 and WinPepi softwares were used and p<0.05. A moderate to high prevalence of overweight/obesity and HDL-cholesterol was found, as well as a high prevalence of high blood pressure and low to moderate PA levels among Portuguese youth. The relationship between BMI and zMR showed that obese adolescents have higher zMR when compared to normal weight or overweight adolescents. This finding suggests that increased levels of PA and reduction in the prevalence of overweight/obesity may have a positive role against the development of metabolic risk factors.

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