P4-320: Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease

2012 ◽  
Vol 8 (4S_Part_21) ◽  
pp. S771-S771
Author(s):  
Yoon-Jee Lee ◽  
Jong-Sung Park ◽  
A-Ryeong Gwoan ◽  
Mark Mattson ◽  
Dong-Gyu Jo
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gamma Secretase ◽  
Beta Secretase

Potential Phyto Therapeutic Approaches for the Treatment of Alzheimer’s Disease: An Overview

2020 ◽  
Vol 06 ◽  
Author(s):  
Chetna Kaushik ◽  
Prarthna Yadav
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Tau Protein ◽  
Symptomatic Relief ◽  
Gamma Secretase ◽  
Therapeutic Approaches ◽  
Common Cause ◽  
Cholinergic Pathways ◽  
Beta Secretase ◽  
Age Dependent

: Alzheimer’s disease is one of the most prevailing age-dependent neurodegenerative disease and the most common cause of dementia. The pharmacological therapies available for the disease provide only symptomatic relief. Plants are being extensively investigated for Alzheimer’s as they are relatively safer and cheaper. This review summarizes recent findings suggesting anti-Alzheimer potential of the plants along with compounds or mechanisms responsible for their efficacy and their therapeutic targets. The findings of recent studies revealed that the plants or the compounds isolated from them exhibit mitigative potential in Alzheimer’s disease by targeting amyloid beta, tau protein, cholinergic pathways via various enzymes like beta secretase, gamma secretase, acetylcholinesterase or receptors involved in these pathways. A number of putative compounds revealed from these studies can be investigated further for the mitigation of Alzheimer’s disease.

Proteolytic processing of the amyloid-beta protein precursor of Alzheimer's disease

2002 ◽  
Vol 38 ◽  
pp. 37-49 ◽  
Author(s):  
Janelle Nunan ◽  
David H Small
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Alternative Pathway ◽  
Protein A ◽  
Proteolytic Processing ◽  
Gamma Secretase ◽  
Amyloid Beta Protein ◽  
Protein Precursor ◽  
Amyloid Beta Protein Precursor

The proteolytic processing of the amyloid-beta protein precursor plays a key role in the development of Alzheimer's disease. Cleavage of the amyloid-beta protein precursor may occur via two pathways, both of which involve the action of proteases called secretases. One pathway, involving beta- and gamma-secretase, liberates amyloid-beta protein, a protein associated with the neurodegeneration seen in Alzheimer's disease. The alternative pathway, involving alpha-secretase, precludes amyloid-beta protein formation. In this review, we describe the progress that has been made in identifying the secretases and their potential as therapeutic targets in the treatment or prevention of Alzheimer's disease.

Oxidative Stress and Amyloid Beta Toxicity in Alzheimer’s Disease: Intervention in a Complex Relationship by Antioxidants

2013 ◽  
Vol 20 (37) ◽  
pp. 4648-4664 ◽  
Author(s):  
S. Chakrabarti ◽  
M. Sinha ◽  
I. Thakurta ◽  
P. Banerjee ◽  
M. Chattopadhyay
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Complex Relationship
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