[P2-553]: THE ASSOCIATION BETWEEN ANTIDEPRESSANT USE AND RISK OF MILD COGNITIVE IMPAIRMENT AND DEMENTIA IN OLDER WOMEN

2017 ◽  
Vol 13 (7S_Part_17) ◽  
pp. P857-P857
Author(s):  
Yue Leng ◽  
Susan Diem ◽  
Katie Stone ◽  
Kristine Yaffe
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yemin Yuan ◽  
Jie Li ◽  
Nan Zhang ◽  
Peipei Fu ◽  
Zhengyue Jing ◽  
...  

Abstract Background Evidence concerning the association between body mass index (BMI) and cognitive function among older people is inconsistent. This study aimed to investigate gender and age as moderators in association between BMI and mild cognitive impairment (MCI) among rural older adults. Methods Data were derived from the 2019 Health Service for Rural Elderly Families Survey in Shandong, China. In total, 3242 people aged 60 years and above were included in the analysis. Multilevel mixed-effects logistic regression was used to examine the moderating roles of gender and age, then further to explore the relationship between BMI and MCI. Results There were 601 (18.5%) participants with MCI. Compared with normal BMI group, low BMI group had a higher risk of MCI among older people [adjusted odds ratio (aOR) = 2.08, 95% confidence interval (CI): 1.26–3.44], women (aOR = 2.06, 95% CI: 1.35–3.12), or the older elderly aged ≥75 years old (aOR = 3.20, 95% CI: 1.34–7.45). This effect remained statistically significant among older women (aOR = 3.38, 95% CI: 1.69–6.73). Among older men, elevated BMI group had a higher risk of MCI (aOR = 2.32, 95% CI: 1.17–4.61) than normal BMI group. Conclusions Gender and age moderated the association between BMI and MCI among Chinese rural older adults. Older women with low BMI were more likely to have MCI, but older men with elevated BMI were more likely to have MCI. These findings suggest rural community managers strengthen the health management by grouping the weight of older people to prevent the risk of dementia.


2012 ◽  
Vol 67 (1) ◽  
pp. 34-36 ◽  
Author(s):  
Kristine Yaffe ◽  
Alison M. Laffan ◽  
Stephanie Litwack Harrison ◽  
Susan Redline ◽  
Adam P. Spira ◽  
...  

2016 ◽  
Vol 65 (3) ◽  
pp. 511-519 ◽  
Author(s):  
Erin S. LeBlanc ◽  
Joanne H. Rizzo ◽  
Kathryn L. Pedula ◽  
Kristine Yaffe ◽  
Kristine E. Ensrud ◽  
...  

2011 ◽  
Vol 70 (5) ◽  
pp. 722-732 ◽  
Author(s):  
Gregory J. Tranah ◽  
Terri Blackwell ◽  
Katie L. Stone ◽  
Sonia Ancoli-Israel ◽  
Misti L. Paudel ◽  
...  

2011 ◽  
Vol 7 ◽  
pp. S373-S373
Author(s):  
Terri Blackwell ◽  
Katie Stone ◽  
Sonia Ancoli-Israel ◽  
Kristine Ensrud ◽  
Jane Cauley ◽  
...  

2021 ◽  
Vol 12 ◽  
Author(s):  
Jindong Chang ◽  
Wenbing Zhu ◽  
Jia Zhang ◽  
Liming Yong ◽  
Ming Yang ◽  
...  

The present study aimed to assess the effects of square dance exercise on the cognitive function and quality of life in older women with mild cognitive impairment and to investigate the mediating role of a depressed mood and reduced quality of life in the relationship between square dance exercise and cognition. The study design was a single-blind whole-group controlled trial. A total of 136 eligible participants were divided according to their nursing home into either an experimental or control group. The nursing home grouping was determined by the drawing of lots. The Montreal Cognitive Assessment (MoCA), Quality of Life (SF-12) and Geriatric Depression Scale (GDS-15) were used to assess participants at baseline, week 9, and week 18, respectively. Generalized estimating equations (GEE) were used to compare the results at baseline with mid-test and post-test changes in cognitive function and quality of life. Maximum likelihood estimation (ML) and robust standard errors were used to perform the mediation model. The study results indicated that the experimental group (compared to the control group) had a significant improvement in cognitive function, quality of life, and mood state at baseline in the mid-test and post-test results. The results of this 18-week experiment showed that the exercise–cognition relationship was significantly mediated by a reduction in depressive symptoms (indirect effect: β = −0.375; 95% CI = −0.864 to −0.069) and an improvement in quality of life (indirect effect: β = −0.678; 95% CI = −1.222 to −0.290). This study revealed the effects of moderate-intensity square dance exercise on cognitive function and quality of life in older Chinese women with mild cognitive impairment and explored the potential mediating mechanisms. These findings can be used to inform the development of public health policies to promote brain health in older adults with mild cognitive impairment.


Author(s):  
Andrew J. Petkus ◽  
Susan M. Resnick ◽  
Stephen R. Rapp ◽  
Mark A. Espeland ◽  
Margaret Gatz ◽  
...  

PLoS ONE ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. e0227924
Author(s):  
Fang Han ◽  
Tyler Bonnett ◽  
Willa D. Brenowitz ◽  
Merilee A. Teylan ◽  
Lilah M. Besser ◽  
...  

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