[P2-086]: EDUCATION AND PHYSICAL ACTIVITY IN RELATION TO FRAILTY AND WHOLE-BRAIN STRUCTURAL HEALTH IN ALZHEIMER'S DISEASE, MILD COGNITIVE IMPAIRMENT, AND NORMAL AGING: RESULTS FROM THE AUSTRALIAN IMAGING, BIOMARKERS AND LIFESTYLE FLAGSHIP STUDY OF AGEING

2017 ◽  
Vol 13 (7S_Part_13) ◽  
pp. P639-P639 ◽  
Author(s):  
Xiaowei Song ◽  
Navjot Dhindsa ◽  
Stephanie R. Rainey-Smith ◽  
Hui Guo ◽  
An Zeng ◽  
...  
Keyword(s):  
Physical Activity ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Normal Aging ◽  
Imaging Biomarkers ◽  
Whole Brain ◽  
Structural Health

scholarly journals Working Memory and Executive Function Decline across Normal Aging, Mild Cognitive Impairment, and Alzheimer’s Disease

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Anna-Mariya Kirova ◽  
Rebecca B. Bays ◽  
Sarita Lagalwar
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Working Memory ◽  
Cognitive Impairment ◽  
Executive Function ◽  
Mild Cognitive Impairment ◽  
Executive Dysfunction ◽  
Normal Aging ◽  
Future Research ◽  
Neurological Differences

Alzheimer’s disease (AD) is a progressive neurodegenerative disease marked by deficits in episodic memory, working memory (WM), and executive function. Examples of executive dysfunction in AD include poor selective and divided attention, failed inhibition of interfering stimuli, and poor manipulation skills. Although episodic deficits during disease progression have been widely studied and are the benchmark of a probable AD diagnosis, more recent research has investigated WM and executive function decline during mild cognitive impairment (MCI), also referred to as the preclinical stage of AD. MCI is a critical period during which cognitive restructuring and neuroplasticity such as compensation still occur; therefore, cognitive therapies could have a beneficial effect on decreasing the likelihood of AD progression during MCI. Monitoring performance on working memory and executive function tasks to track cognitive function may signal progression from normal cognition to MCI to AD. The present review tracks WM decline through normal aging, MCI, and AD to highlight the behavioral and neurological differences that distinguish these three stages in an effort to guide future research on MCI diagnosis, cognitive therapy, and AD prevention.

Increasing Diagnostic Accuracy of Mild Cognitive Impairment due to Alzheimer’s Disease by User-Independent, Web-Based Whole-Brain Volumetry

2018 ◽  
Vol 65 (4) ◽  
pp. 1459-1467 ◽  
Author(s):  
Dennis M. Hedderich ◽  
Judith E. Spiro ◽  
Oliver Goldhardt ◽  
Johannes Kaesmacher ◽  
Benedikt Wiestler ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Diagnostic Accuracy ◽  
Whole Brain ◽  
Web Based ◽  
Brain Volumetry
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