IC-P-103: LOGICAL MEMORY DEFICITS ACROSS ALZHEIMER'S DISEASE SPECTRUM ARE ASSOCIATED WITH PATTERNS OF TAU PROPAGATION PREDICTED BY BRAAK STAGING

Little is known about possible differences in the memory deficits that occur in Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). We compared 24 autopsy-confirmed DLB and 24 age-, education-, and MMSE-matched autopsy-confirmed AD patients on the California Verbal Learning Test (CVLT) and the Wechsler Memory Scale-Revised Logical Memory subtest. The DLB and AD groups were similarly impaired on CVLT Total Learning (Trials 1–5) and Long Delayed Free Recall, but the DLB group demonstrated relative improvement in Savings scores and on recognition testing compared to the AD group. Likewise, the patient groups were equally impaired on Logical Memory immediate and delayed recall, but the DLB group's Saving scores were significantly better than those of the AD patients. These results indicate that while both DLB and AD patients exhibit significant memory impairment, the ability to consolidate information may be less severely impaired in DLB patients than in AD patients. (JINS, 2004, 10, 689–697.)

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Dimethyl fumarate attenuates working memory deficits in both young and old rats in the streptozotocin-induced model of sporadic Alzheimer’s disease

10.26226/morressier.5785edcfd462b80296c99f5f ◽

2016 ◽

Author(s):

Ewelina Kurowska

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Working Memory ◽

Dimethyl Fumarate ◽

Memory Deficits ◽

Sporadic Alzheimer’S Disease ◽

Old Rats

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Faculty Opinions recommendation of Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.4693956.4576054 ◽

2010 ◽

Author(s):

Francine Benes ◽

Barbara Gisabella

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Mouse Model ◽

Histone Deacetylases ◽

Memory Deficits ◽

Contextual Memory ◽

Model Of Alzheimer’S Disease ◽

Class 1

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Transcranial direct current stimulation does not improve memory deficits or alter pathological hallmarks in a rodent model of Alzheimer's disease

Journal of Psychiatric Research ◽

10.1016/j.jpsychires.2019.04.016 ◽

2019 ◽

Vol 114 ◽

pp. 93-98 ◽

Cited By ~ 5

Author(s):

Elise Gondard ◽

Maria Luisa Soto-Montenegro ◽

Amanda Cassol ◽

Andres M. Lozano ◽

Clement Hamani

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Direct Current ◽

Transcranial Direct Current Stimulation ◽

Memory Deficits ◽

Rodent Model ◽

Direct Current Stimulation ◽

Model Of Alzheimer’S Disease

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Levodopa ameliorates learning and memory deficits in a murine model of Alzheimer’s disease

Neurobiology of Aging ◽

10.1016/j.neurobiolaging.2007.11.010 ◽

2009 ◽

Vol 30 (8) ◽

pp. 1192-1204 ◽

Cited By ~ 48

Author(s):

Oliver Ambrée ◽

Helene Richter ◽

Norbert Sachser ◽

Lars Lewejohann ◽

Ekrem Dere ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Learning And Memory ◽

Murine Model ◽

Memory Deficits ◽

Model Of Alzheimer’S Disease ◽

Learning And Memory Deficits

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Women have Farther to Fall: Gender Differences Between Normal Elderly and Alzheimer's Disease in Verbal Memory Engender Better Detection of Alzheimer's Disease in Women

Journal of the International Neuropsychological Society ◽

10.1017/s1355617711000452 ◽

2011 ◽

Vol 17 (4) ◽

pp. 654-662 ◽

Cited By ~ 31

Author(s):

Robert M. Chapman ◽

Mark Mapstone ◽

Margaret N. Gardner ◽

Tiffany C. Sandoval ◽

John W. McCrary ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Gender Differences ◽

Verbal Memory ◽

Control Group ◽

Large Drop ◽

Delayed Recall ◽

Logical Memory ◽

Wechsler Memory Scale ◽

Immediate Recall

AbstractWe analyzed verbal episodic memory learning and recall using the Logical Memory (LM) subtest of the Wechsler Memory Scale-III to determine how gender differences in AD compare to those seen in normal elderly and whether or not these differences impact assessment of AD. We administered the LM to both an AD and a Control group, each comprised of 21 men and 21 women, and found a large drop in performance from normal elders to AD. Of interest was a gender interaction whereby the women's scores dropped 1.6 times more than the men's did. Control women on average outperformed Control men on every aspect of the test, including immediate recall, delayed recall, and learning. Conversely, AD women tended to perform worse than AD men. Additionally, the LM achieved perfect diagnostic accuracy in discriminant analysis of AD versus Control women, a statistically significantly higher result than for men. The results indicate the LM is a more powerful and reliable tool in detecting AD in women than in men. (JINS, 2011, 17, 654–662)

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