Ephrin B2 Regulates Inflammatory Cell Accumulation in a Rat Aortic Transplant Model

The inflammatory response adjacent to implants has not been well-investigated and may influence peri-implant tissue levels. The purpose of this study was to assess, histomorphometrically, (1) the timing of abutment connection and (2) the influence of a microgap. Three implant designs were placed in the mandibles of dogs. Two-piece implants were placed at the alveolar crest and abutments connected either at initial surgery (non-submerged) or three months later (submerged). The third implant was one-piece. Adjacent interstitial tissues were analyzed. Both two-piece implants resulted in a peak of inflammatory cells approximately 0.50 mm coronal to the microgap and consisted primarily of neutrophilic polymorphonuclear leukocytes. For one-piece implants, no such peak was observed. Also, significantly greater bone loss was observed for both two-piece implants compared with one-piece implants. In summary, the absence of an implant-abutment interface (microgap) at the bone crest was associated with reduced peri-implant inflammatory cell accumulation and minimal bone loss.

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Elevated Plasma Level of Interferon-λ1 in Chronic Spontaneous Urticaria: Upregulated Expression in CD8+and Epithelial Cells and Induction of Inflammatory Cell Accumulation

Mediators of Inflammation ◽

10.1155/2016/5032051 ◽

2016 ◽

Vol 2016 ◽

pp. 1-13 ◽

Cited By ~ 3

Author(s):

S. F. Wang ◽

X. Q. Gao ◽

Y. N. Xu ◽

D. N. Li ◽

H. Y. Wang ◽

...

Keyword(s):

Mast Cells ◽

Inflammatory Cell ◽

Inflammatory Cells ◽

Chronic Spontaneous Urticaria ◽

Intercellular Adhesion Molecule ◽

Double Labeling ◽

Cell Accumulation ◽

Healthy Control ◽

Dose Dependent Increase ◽

Dose Dependent

Interferon- (IFN-)λ1 is regarded as a potent bio-active molecule in innate immunity. However, little is known about its role in chronic spontaneous urticaria (CSU). We therefore investigated expression of IFN-λ1 in CSU, its cellular location, and its influence on inflammatory cell accumulation by using flow cytometry analysis, skin tissue dispersion, immunohistochemical stain, and a mouse peritoneal inflammation model. The results showed that level of IFN-λ1 was 2.0-fold higher in plasma of the patients with CSU than the level in healthy control (HC) subjects. Among leukocytes examined, only CD8+T cells expressed more IFN-λ1 in CSU blood. Double labeling immunohistochemical staining revealed that IFN-λ1+inflammatory cells such as mast cells, eosinophils, B cells, neutrophils, and macrophages were mainly located in dermis, whereas epidermis tissue highly expressed IFN-λ1. IFN-λ1 induced a dose-dependent increase in number of eosinophils, lymphocytes, mast cells, macrophages, and neutrophils in the peritoneum of mice at 6 h following injection, which was inhibited by pretreatment of the animals with anti-intercellular adhesion molecule- (ICAM-) 1 and/or anti-L-selectin antibodies. In conclusion, IFN-λ1 is likely to play a role in the pathogenesis of CSU. Blocking IFN-λ1 production may help to reduce the accumulation of inflammatory cells in the involved CSU skin.

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Beneficial Effects of Cod Protein on Inflammatory Cell Accumulation in Rat Skeletal Muscle after Injury Are Driven by Its High Levels of Arginine, Glycine, Taurine and Lysine

PLoS ONE ◽

10.1371/journal.pone.0077274 ◽

2013 ◽

Vol 8 (10) ◽

pp. e77274 ◽

Cited By ~ 15

Author(s):

Junio Dort ◽

Nadine Leblanc ◽

Julie Maltais-Giguère ◽

Bjørn Liaset ◽

Claude H. Côté ◽

...

Keyword(s):

Skeletal Muscle ◽

Inflammatory Cell ◽

Rat Skeletal Muscle ◽

Beneficial Effects ◽

Cell Accumulation

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Effect of single and chronic treatment of SDZ1MM 125 by inhalation on allergen-induced inflammatory cell accumulation in the airways of actively sensitized Brown-Norway rats.

The Japanese Journal of Pharmacology ◽

10.1016/s0021-5198(19)37033-7 ◽

1996 ◽

Vol 71 ◽

pp. 198

Author(s):

Ken-ichiro Hoshiko ◽

Naoko Nakamaru ◽

Ryosei Kawai ◽

Michiko Terunuma ◽

Kunihiko Kitagaki ◽

...

Keyword(s):

Chronic Treatment ◽

Inflammatory Cell ◽

Brown Norway ◽

Cell Accumulation ◽

Norway Rats

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Effect of single and multiple inhalation of SDZ OXL 400 on antigen-induced inflammatory cell accumulation into the airways of actively sensitized guinea-pigs

The Japanese Journal of Pharmacology ◽

10.1016/s0021-5198(19)47216-8 ◽

1995 ◽

Vol 67 ◽

pp. 313

Author(s):

Ken-ichiro Hoshiko ◽

Kunihiko Kitagaki ◽

Naoko Nakamaru ◽

Karima Boubekeur

Keyword(s):

Guinea Pigs ◽

Inflammatory Cell ◽

Cell Accumulation

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LXA4 Inhibits Lipopolysaccharide-Induced Inflammatory Cell Accumulation by Resident Macrophages in Mice

Journal of Inflammation Research ◽

10.2147/jir.s301292 ◽

2021 ◽

Vol Volume 14 ◽

pp. 1375-1385

Author(s):

Hong-Xia Mei ◽

Yang Ye ◽

Hao-Ran Xu ◽

Shu-Yang Xiang ◽

Qian Yang ◽

...

Keyword(s):

Inflammatory Cell ◽

Cell Accumulation

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Steroids and Asthma

PEDIATRICS ◽

10.1542/peds.96.2.347 ◽

1995 ◽

Vol 96 (2) ◽

pp. 347-348 ◽

Cited By ~ 1

Author(s):

Gail G. Shapiro

Keyword(s):

Single Dose ◽

Inflammatory Cell ◽

Inflammatory Cells ◽

Forced Expiratory Volume ◽

Chronic Asthma ◽

Optimal Management ◽

Concomitant Increase ◽

Biopsy Specimens ◽

Destructive Change ◽

Cell Accumulation

It is impossible to read about asthma in the 1990s without being informed that it is an inflammatory disease and that all but the mildest cases require anti-inflammatory therapy for optimal management.1 Bronchoalveolar lavage studies document the influx of inflammatory cells and the upregulation of inflammatory cytokines in bronchial washings of patients with chronic asthma.2 Biopsy specimens confirm an inflammatory cell accumulation and the destructive change to the epithelium that one would expect from this insult.3 The pathophysiology of asthma would seem to justify the use of corticosteroids for its management. A single dose of prednisone can be shown to decrease inflammatory leukotrienes while there is a concomitant increase in forced expiratory volume in 1 second.4

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Peri-implant Inflammation Defined by the Implant-Abutment Interface

Journal of Dental Research ◽

10.1177/154405910608500515 ◽

2006 ◽

Vol 85 (5) ◽

pp. 473-478 ◽

Cited By ~ 248

Author(s):

N. Broggini ◽

L.M. McManus ◽

J.S. Hermann ◽

R. Medina ◽

R.K. Schenk ◽

...

Keyword(s):

Bone Loss ◽

Polymorphonuclear Leukocytes ◽

Inflammatory Cell ◽

Alveolar Bone ◽

Inflammatory Cells ◽

Maximum Density ◽

Interface Position ◽

Cell Accumulation ◽

Implant Abutment ◽

Neutrophilic Polymorphonuclear Leukocytes

An implant-abutment interface at the alveolar bone crest is associated with sustained peri-implant inflammation; however, whether magnitude of inflammation is proportionally dependent upon interface position remains unknown. This study compared the distribution and density of inflammatory cells surrounding implants with a supracrestal, crestal, or subcrestal implant-abutment interface. All implants developed a similar pattern of peri-implant inflammation: neutrophilic polymorphonuclear leukocytes (neutrophils) maximally accumulated at or immediately coronal to the interface. However, peri-implant neutrophil accrual increased progressively as the implant-abutment interface depth increased, i.e., subcrestal interfaces promoted a significantly greater maximum density of neutrophils than did supracrestal interfaces (10,512 ± 691 vs. 2398 ± 1077 neutrophils/mm2). Moreover, inflammatory cell accumulation below the original bone crest was significantly correlated with bone loss. Thus, the implant-abutment interface dictates the intensity and location of peri-implant inflammatory cell accumulation, a potential contributing component in the extent of implant-associated alveolar bone loss.

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