Color by Numbers: When Population Skin Pigmentation Is not Political but a Polytypical Evaluation Exercise to Measure Vitamin D, Diseases, and Skin Pigmentation

2016 ◽  
Vol 116 (8) ◽  
pp. 1251-1256 ◽  
Author(s):  
Angela Chalé ◽  
Christina Chalé
Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1759
Author(s):  
Patrice Jones ◽  
Mark Lucock ◽  
Martin Veysey ◽  
Emma Beckett

We thank Elias and Williams for their interest in our review [...]


Nutrients ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 676 ◽  
Author(s):  
Carsten Carlberg

Nutrigenomics studies how environmental factors, such as food intake and lifestyle, influence the expression of the genome. Vitamin D3 represents a master example of nutrigenomics, since via its metabolite 1α,25-dihydroxyvitamin D3, which binds with high-affinity to the vitamin D receptor, the secosteroid directly affects the epigenome and transcriptome at thousands of loci within the human genome. Vitamin D is important for both cellular metabolism and immunity, as it controls calcium homeostasis and modulates the response of the innate and adaptive immune system. At sufficient UV-B exposure, humans can synthesize vitamin D3 endogenously in their skin, but today’s lifestyle often makes the molecule a true vitamin and micronutrient that needs to be taken up by diet or supplementation with pills. The individual’s molecular response to vitamin D requires personalized supplementation with vitamin D3, in order to obtain optimized clinical benefits in the prevention of osteoporosis, sarcopenia, autoimmune diseases, and possibly different types of cancer. The importance of endogenous synthesis of vitamin D3 created an evolutionary pressure for reduced skin pigmentation, when, during the past 50,000 years, modern humans migrated from Africa towards Asia and Europe. This review will discuss different aspects of how vitamin D interacts with the human genome, focusing on nutritional epigenomics in context of immune responses. This should lead to a better understanding of the clinical benefits of vitamin D.


2020 ◽  
Vol 184 (4) ◽  
pp. 1060-1077
Author(s):  
Bruna Oliveira Missaggia ◽  
Guillermo Reales ◽  
Gabriela B. Cybis ◽  
Tábita Hünemeier ◽  
Maria Cátira Bortolini

2012 ◽  
Vol 367 (1590) ◽  
pp. 785-792 ◽  
Author(s):  
Nina G. Jablonski ◽  
George Chaplin

Human skin pigmentation evolved as a compromise between the conflicting physiological demands of protection against the deleterious effects of ultraviolet radiation (UVR) and photosynthesis of UVB-dependent vitamin D 3 . Living under high UVR near the equator, ancestral Homo sapiens had skin rich in protective eumelanin. Dispersals outside of the tropics were associated with positive selection for depigmentation to maximize cutaneous biosynthesis of pre-vitamin D 3 under low and highly seasonal UVB conditions. In recent centuries, migrations and high-speed transportation have brought many people into UVR regimes different from those experienced by their ancestors and, accordingly, exposed them to new disease risks. These have been increased by urbanization and changes in diet and lifestyle. Three examples—nutritional rickets, multiple sclerosis (MS) and cutaneous malignant melanoma (CMM)—are chosen to illustrate the serious health effects of mismatches between skin pigmentation and UVR. The aetiology of MS in particular provides insight into complex and contingent interactions of genetic and environmental factors necessary to trigger lethal disease states. Low UVB levels and vitamin D deficiencies produced by changes in location and lifestyle pose some of the most serious disease risks of the twenty-first century.


2012 ◽  
Vol 89 (1) ◽  
pp. 219-226 ◽  
Author(s):  
Jessica Cargill ◽  
Robyn M. Lucas ◽  
Peter Gies ◽  
Kerryn King ◽  
Ashwin Swaminathan ◽  
...  

2008 ◽  
Vol 20 (1) ◽  
pp. 133-140 ◽  
Author(s):  
T. Hagenau ◽  
R. Vest ◽  
T. N. Gissel ◽  
C. S. Poulsen ◽  
M. Erlandsen ◽  
...  

2021 ◽  
Vol 10 (44) ◽  
pp. 3730-3735
Author(s):  
Rohit Kumar Agrawal ◽  
Preeti Sharma ◽  
Pradeep Kumar ◽  
Mehek Jaggi ◽  
Rachna Sharma

BACKGROUND Exclusive breastfeeding is recommended up to 6 months of age with all its beneficial effects on child survival. Several studies have shown that adequate intake of vitamin D cannot be met with human milk as the sole source of vitamin D, although risk factors for developing vitamin D deficiency may be low maternal levels of vitamin D, indoor confinement during the day, living at higher altitudes, living in urban areas with tall buildings, air pollution, darker skin pigmentation, use of sunscreen and covering much over the body when outside. An infant who is entirely on breastfeeding and has minimal to no exposure to sunlight is more prone to the development of hypovitaminosis-D. The main purpose of the study was to identify the prevalence & high-risk groups of hypovitaminosis D in exclusively breastfed babies. METHODS It was a cross-sectional observational study consisting of 30 entirely breastfed healthy full-term babies with a birth weight > 2.5 kg. Babies born to mothers with a history of pre-eclampsia, gestational diabetes, antepartum haemorrhage, tuberculosis, and other chronic medical illnesses were excluded from the study. The period of study was from 1st August 2019 to 30th September 2019. Their serum vitamin D3, serum calcium, serum phosphate, and alkaline phosphatase levels were measured using appropriate methods. RESULTS In our study, 25 infants out of 30 came out as vitamin D deficient. The prevalence of vitamin D3 was found to be 83 %. CONCLUSIONS Breastfeeding is of utmost importance but the nutritional status of the mother, proper exposure to the sun, and vitamin D supplementation are the factors that should be taken care of for the prevention of hypovitaminosis D. KEY WORDS Vitamin D3, Hypovitaminosis D, Exclusive Breast Feeding, term babies, infants, Sun Exposure, Rickets


2019 ◽  
Vol 18 (2) ◽  
pp. 448-458 ◽  
Author(s):  
Pameli Datta ◽  
Peter Alshede Philipsen ◽  
Peter Olsen ◽  
Bibi Petersen ◽  
Jeppe Dyrberg Andersen ◽  
...  

The long-term UVB induced serum 25(OH)D increase was influenced by pigment gene polymorphisms rather than measured facultative skin pigmentation.


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