Periodontal disease in patients with rheumatoid arthritis in Sub-Saharan Africa: A case-control study

2017 ◽  
Vol 84 (1) ◽  
pp. 113-114 ◽  
Author(s):  
Dieu-Donné Ouédraogo ◽  
Joelle Tiendrébéogo ◽  
Patrice Laurent Wendpouiré Guiguimdé ◽  
Pascal Ismaël Nikiéma ◽  
Dieudonné Ouédraogo ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Periodontal Disease ◽  
Case Control Study ◽  
Case Control ◽  
Sub Saharan Africa ◽  
Sub Saharan ◽  
Control Study

scholarly journals Inflammatory bowel disease in sub-Saharan Africa: a protocol of a prospective registry with a nested case–control study

BMJ Open ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. e039456
Author(s):  
Leolin Katsidzira ◽  
Wisdom F Mudombi ◽  
Rudo Makunike-Mutasa ◽  
Bahtiyar Yilmaz ◽  
Annika Blank ◽  
...  
Keyword(s):  
Risk Factors ◽  
Inflammatory Bowel Disease ◽  
Case Control Study ◽  
Alpha Diversity ◽  
Case Control ◽  
Sub Saharan Africa ◽  
Inflammatory Bowel ◽  
Sub Saharan ◽  
Nested Case Control ◽  
Control Study

IntroductionThe epidemiology of inflammatory bowel disease (IBD) in sub-Saharan Africa is poorly documented. We have started a registry to determine the burden, phenotype, risk factors, disease course and outcomes of IBD in Zimbabwe.Methods and analysisA prospective observational registry with a nested case–control study has been established at a tertiary hospital in Harare, Zimbabwe. The registry is recruiting confirmed IBD cases from the hospital, and other facilities throughout Zimbabwe. Demographic and clinical data are obtained at baseline, 6 months and annually. Two age and sex-matched non-IBD controls per case are recruited—a sibling or second-degree relative, and a randomly selected individual from the same neighbourhood. Cases and controls are interviewed for potential risk factors of IBD, and dietary intake using a food frequency questionnaire. Stool is collected for 16S rRNA-based microbiota profiling, and along with germline DNA from peripheral blood, is being biobanked. The estimated sample size is 86 cases and 172 controls, and the overall registry is anticipated to run for at least 5 years. Descriptive statistics will be used to describe the demographic and phenotypic characteristics of IBD, and incidence and prevalence will be estimated for Harare. Risk factors for IBD will be analysed using conditional logistic regression. For microbial analysis, alpha diversity and beta diversity will be compared between cases and controls, and between IBD phenotypes. Mann-Whitney U tests for alpha diversity and Adonis (Permutational Multivariate Analysis of Variance) for beta diversity will be computed.Ethics and disseminationEthical approval has been obtained from the Parirenyatwa Hospital’s and University of Zimbabwe’s research ethics committee and the Medical Research Council of Zimbabwe. Findings will be discussed with patients, and the Zimbabwean Ministry of Health. Results will be presented at scientific meetings, published in peer reviewed journals, and on social media.Trial registration numberNCT04178408.

scholarly journals Rubella in Sub-Saharan Africa and sensorineural hearing loss: a case control study

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Cristina Caroça ◽  
Vera Vicente ◽  
Paula Campelo ◽  
Maria Chasqueira ◽  
Helena Caria ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Case Control Study ◽  
Case Control ◽  
Sensorineural Hearing ◽  
Sub Saharan Africa ◽  
Sub Saharan ◽  
Control Study

Periodontal disease in Chinese patients with rheumatoid arthritis: A case–control study

Oral Diseases ◽  
2019 ◽  
Vol 25 (8) ◽  
pp. 2003-2009 ◽  
Author(s):  
Rui Zhao ◽  
Chaoyu Gu ◽  
Qiuxiang Zhang ◽  
Wei Zhou ◽  
Guijuan Feng ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Periodontal Disease ◽  
Case Control Study ◽  
Case Control ◽  
Chinese Patients ◽  
Control Study

scholarly journals Are There Any Common Genetic Risk Markers for Rheumatoid Arthritis and Periodontal Diseases? A Case-Control Study

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Susanne Schulz ◽  
Natalie Pütz ◽  
Elisa Jurianz ◽  
Hans-Günter Schaller ◽  
Stefan Reichert
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Periodontal Disease ◽  
Case Control Study ◽  
Multivariate Analyses ◽  
Periodontal Diseases ◽  
Case Control ◽  
Genetic Variations ◽  
The Impact ◽  
Control Study

Background. Several studies suggest that there is a biologically plausible connection between rheumatoid arthritis (RA) and periodontal diseases (PD). Both disorders are characterized as multifactorial diseases potentially sharing common risk factors. Based on the inflammatory nature of RA and PD, the impact of genetic variations of genes of the immune system on both diseases was studied in this study.Materials and Methods. We conducted a case-control study (n=201) comparing 101 RA patients suffering from periodontal disease of different severities (no/mild PD vs. severe PD) with 100 systemically healthy controls without RA and severe PD. The genotype, allele, and haplotype distributions of 22 SNPs of 13 pro- and anti-inflammatory cytokines were assessed applying sequence-specific PCR.Results. Evaluating the impact of cytokine SNPs in RA, we identified the G allele of rs1801275 in IL4Rα(p=0.043) and the G allele of rs361525 in TNFα(p=0.005) as disease-associated risk factors in bivariate analyses. In multivariate analyses, these significant associations could not be proven. The A allele of rs2430561 in IFNγwas indicative for severe periodontitis among the patients with rheumatoid arthritis (p=0.039). Investigating the impact of rs2430561 in IFNγon comorbidity using binary logistic regression analyses, the A allele was confirmed as an independent risk factor for severe periodontal disease and RA (p=0.024).Conclusions. These results emphasize the association of genetic variations in proinflammatory cytokines (TNFαand IFNγ) and cytokine receptor (IL4Rα) and RA and periodontal diseases. In multivariate analyses, the A allele of IFNγwas proven to be a significant marker of RA and PD comorbidities. The study broadens the knowledge about disease-specific differences in genetic composition and provides an improved understanding of a possible association of both diseases.

Periodontal disease is significantly higher in non-smoking treatment-naive rheumatoid arthritis patients: results from a case-control study

2012 ◽  
Vol 71 (9) ◽  
pp. 1541-1544 ◽  
Author(s):  
Damodaram Potikuri ◽  
Kalyan Chakravarthy Dannana ◽  
Suresh Kanchinadam ◽  
Sumeet Agrawal ◽  
Anuradha Kancharla ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Periodontal Disease ◽  
Case Control Study ◽  
Case Control ◽  
Treatment Naïve ◽  
Control Study

scholarly journals Sachet water consumption as a risk factor for cholera in urban settings: Findings from a case control study in Kinshasa, Democratic Republic of the Congo during the 2017–2018 outbreak

2021 ◽  
Vol 15 (7) ◽  
pp. e0009477
Author(s):  
Placide Mbala-Kingebeni ◽  
Florian Vogt ◽  
Berthe Miwanda ◽  
Tresor Sundika ◽  
Nancy Mbula ◽  
...  
Keyword(s):  
Risk Factors ◽  
Democratic Republic ◽  
Case Control Study ◽  
Case Control ◽  
Sub Saharan Africa ◽  
P Value ◽  
Republic Of The Congo ◽  
Sub Saharan ◽  
Context Specific ◽  
Control Study

Background Behavioural risk factors for cholera are well established in rural and semi-urban contexts, but not in densely populated mega-cities in Sub-Saharan Africa. In November 2017, a cholera epidemic occurred in Kinshasa, the Democratic Republic of the Congo, where no outbreak had been recorded for nearly a decade. During this outbreak, we investigated context-specific risk factors for cholera in an urban setting among a population that is not frequently exposed to cholera. Methodology/Principal findings We recruited 390 participants from three affected health zones of Kinshasa into a 1:1 matched case control study. Cases were identified from cholera treatment centre admission records, while controls were recruited from the vicinity of the cases’ place of residence. We used standardized case report forms for the collection of socio-demographic and behavioural risk factors. We used augmented backward elimination in a conditional logistic regression model to identify risk factors. The consumption of sachet water was strongly associated with the risk of being a cholera case (p-value 0.019), which increased with increasing frequency of consumption from rarely (OR 2.2, 95% CI 0.9–5.2) to often (OR 4.0, 95% CI 1.6–9.9) to very often (OR 4.1, 95% CI 1.0–16.7). Overall, more than 80% of all participants reported consumption of this type of drinking water. The risk factors funeral attendance and contact with someone suffering from diarrhoea showed a p-value of 0.09 and 0.08, respectively. No socio-demographic characteristics were associated with the risk of cholera. Conclusions/Significance Drinking water consumption from sachets, which are sold informally on the streets in most Sub-Saharan African cities, are an overlooked route of infection in urban cholera outbreaks. Outbreak response measures need to acknowledge context-specific risk factors to remain a valuable tool in the efforts to achieve national and regional targets to reduce the burden of cholera in Sub-Saharan Africa.

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