Simultaneous determination of zopiclone and its degradation product and main impurity (2-amino-5-chloropyridine) by micellar liquid chromatography with time-programmed fluorescence detection: Preliminary investigation for biological monitoring

2012 ◽  
Vol 907 ◽  
pp. 49-55 ◽  
Author(s):  
R.N. El-Shaheny ◽  
A. Alattas ◽  
J.J. Nasr ◽  
N. El-Enany ◽  
F. Belal
Keyword(s):  
Liquid Chromatography ◽  
Biological Monitoring ◽  
Simultaneous Determination ◽  
Fluorescence Detection ◽  
Degradation Product ◽  
Preliminary Investigation ◽  
Micellar Liquid Chromatography ◽  
Main Impurity

scholarly journals Simultaneous Determination of Residual Antiparasitic Lactones in Bovine Muscle and Liver by Liquid Chromatography with Fluorescence Detection

2003 ◽  
Vol 86 (3) ◽  
pp. 490-493 ◽  
Author(s):  
Tomoko Nagata ◽  
Fumio Miyamoto ◽  
Yasuyuki Hasegawa ◽  
Eiichi Ashizawa
Keyword(s):  
Liquid Chromatography ◽  
Ethyl Acetate ◽  
Simultaneous Determination ◽  
Fluorescence Detection ◽  
Dimethyl Formamide ◽  
Bovine Muscle

Abstract Abamectin, doramectin, eprinomectin, ivermectin, milbemectin, and moxidectin in bovine muscle and liver were extracted with acetonitrile. The extracts were partitioned with n-hexane and then evaporated to dryness. The residue was cleaned up on Bond Elute NH2 cartridge, and the drugs were eluted from the cartridge with methanol–ethyl acetate (3 + 7). The eluate was evaporated to dryness, and residues were derivatized with N,N-dimethyl-formamide–acetic anhyride-1-methylimidazole. The derivatives were determined by liquid chromatography with fluorescence detection. Recoveries of the 6 drugs were 79.6–63.8% in muscle and 71.6–60.6% in liver at 0.01 ppm levels. The quantitation limits were 5 ppb for each drug.

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