Amalgamation of stress degradation and metabolite profiling in rat urine and feces for characterization of oxidative metabolites of flibanserin using UHPLC-Q-TOF-MS/MS, H/D exchange and NMR technique

2020 ◽  
Vol 1139 ◽  
pp. 121993 ◽  
Author(s):  
Manish Kumar Sharma ◽  
Ravi P. Shah ◽  
Pinaki Sengupta
Keyword(s):  
Metabolite Profiling ◽  
Rat Urine ◽  
Oxidative Metabolites ◽  
Stress Degradation ◽  
Tof Ms

Characterization of the stress degradation products of tolvaptan by UPLC-Q-TOF-MS/MS

RSC Advances ◽  
2015 ◽  
Vol 5 (27) ◽  
pp. 21142-21152 ◽  
Author(s):  
Prinesh N. Patel ◽  
D. Rajesh Kumar ◽  
S. Gananadhamu ◽  
R. Srinivas
Keyword(s):  
Degradation Products ◽  
Forced Degradation ◽  
Dry Heat ◽  
Stress Degradation ◽  
Tof Ms

TVT was subjected to forced degradation under hydrolysis, oxidation, dry heat and photolysis conditions and the degradation products (DPs) formed have been characterized through UPLC-PDA and UPLC-Q-TOF-MS/MS studies.

Stress degradation study of bortezomib: Effect of co-solvent, isolation and characterization of degradation products by UHPLC-Q-TOF-MS/MS, NMR and toxicity studies

2021 ◽  
Author(s):  
Suresh U ◽  
Roshan M Borkar ◽  
G. Shankar ◽  
Aishwarya Jala ◽  
T Sony ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Degradation Products ◽  
Reversible Inhibitor ◽  
Hematological Cancer ◽  
Degradation Study ◽  
Toxicity Studies ◽  
Isolation And Characterization ◽  
Stress Degradation ◽  
Tof Ms

Bortezomib (BTZ) is a first in class, potent reversible inhibitor of proteasome used in the treatment of multiple myeloma, the second most common hematological cancer. Stress degradation studies were performed...

Characterization of polyethers using different methods: SFC, LAC and SEC with different detectors, and MALDI-TOF-MS

1996 ◽  
Vol 110 (1) ◽  
pp. 231-240 ◽  
Author(s):  
Bernd Trathnigg ◽  
Bernhard Maier ◽  
Günther Schulz ◽  
Ralph-Peter Krüger ◽  
Ulrich Just
Keyword(s):  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Tof Ms

Characterization of lipid profiling in three parts (muscle, head and viscera) of tilapia (Oreochromis niloticus) using lipidomics with UPLC-ESI-Q-TOF-MS

2021 ◽  
Vol 347 ◽  
pp. 129057
Author(s):  
Chen He ◽  
Jun Cao ◽  
Yuyan Bao ◽  
Zexin Sun ◽  
Zhongyuan Liu ◽  
...  
Keyword(s):  
Oreochromis Niloticus ◽  
Lipid Profiling ◽  
Tof Ms

Metabolite profiling of steroidal glycosides in the rhizome of Aspidistra sichuanensis using UPLC/Q-TOF MS E

2017 ◽  
Vol 415 ◽  
pp. 63-84 ◽  
Author(s):  
Jie Peng ◽  
Yang Zhao ◽  
Lu Xu ◽  
Li-ping Kang ◽  
Jiang-ming Cui ◽  
...  
Keyword(s):  
Metabolite Profiling ◽  
Steroidal Glycosides ◽  
Tof Ms
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