Novel scheme for rapid synthesis of hollow mesoporous silica nanoparticles (HMSNs) and their application as an efficient delivery carrier for oral bioavailability improvement of poorly water-soluble BCS type II drugs

2019 ◽  
Vol 176 ◽  
pp. 185-193 ◽  
Author(s):  
Tiantian Li ◽  
Tianjiao Geng ◽  
Aquib Md ◽  
Parikshit Banerjee ◽  
Bo Wang
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Oral Bioavailability ◽  
Mesoporous Silica Nanoparticles ◽  
Water Soluble ◽  
Type Ii ◽  
Rapid Synthesis ◽  
Efficient Delivery ◽  
Poorly Water Soluble ◽  
Hollow Mesoporous Silica

scholarly journals Enlarged Pore Size Chiral Mesoporous Silica Nanoparticles Loaded Poorly Water-Soluble Drug Perform Superior Delivery Effect

Molecules ◽  
2019 ◽  
Vol 24 (19) ◽  
pp. 3552 ◽  
Author(s):  
Yingyu Guo ◽  
Kaijun Gou ◽  
Baixue Yang ◽  
Yumei Wang ◽  
Xueyu Pu ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Water Soluble ◽  
Synthesis Process ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Anti Inflammatory ◽  
Poorly Water Soluble Drug

Large mesopores of chiral silica nanoparticles applied as drug carrier are worth studying. In this study, chiral mesoporous silica nanoparticles (CMSN) and enlarged chiral mesoporous silica nanoparticles (E-CMSN) with a particle size from 200 to 300 nm were synthesized. Fourier transform infrared spectrometer (FTIR), circular dichroism spectrum, scanning electron microscopy (SEM), transmission electron microscope (TEM), and nitrogen adsorption/desorption measurement were adopted to explore their characteristics. The results showed that the surface area, pore volume, and pore diameter of E-CMSN were higher than those of CMSN due to enlarged mesopores. Poorly water-soluble drug nimesulide (NMS) was taken as the model drug and loaded into carriers using adsorption method. After NMS was loaded into CMSN and E-CMSN, most crystalline NMS converted to amorphous phase and E-CMSN was superior. The anti-inflammatory pharmacodynamics and in vivo pharmacokinetics results were consistent with the wetting property and in vitro drug dissolution results, verifying that NMS/E-CMSN exhibited superior NMS delivery system based on its higher oral relative bioavailability and anti-inflammatory effect because its enlarge mesopores contributed to load and release more amorphous NMS. The minor variations in the synthesis process contributed to optimize the chiral nano-silica drug delivery system.

A soft–hard template approach towards hollow mesoporous silica nanoparticles with rough surfaces for controlled drug delivery and protein adsorption

2015 ◽  
Vol 3 (31) ◽  
pp. 6480-6489 ◽  
Author(s):  
Haijiao Zhang ◽  
Huijuan Xu ◽  
Minghong Wu ◽  
Yufang Zhong ◽  
Donghai Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Protein Adsorption ◽  
Rough Surfaces ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Delivery ◽  
Hard Template ◽  
Hollow Mesoporous Silica

Novel hollow mesoporous silica nanoparticles (HMSNs) with rough surfaces have been successfully prepared using a facile soft–hard template route.

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