Pretreatment with a stress-dose but not a high-dose infusion of hydrocortisone maintains heart rate variability during human endotoxemia

2008 ◽  
Vol 23 (2) ◽  
pp. 265
Author(s):  
Athos J. Rassias ◽  
Paul M. Guyre ◽  
Mark P. Yeager
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
High Dose ◽  
Human Endotoxemia ◽  
Dose Infusion ◽  
Stress Dose

scholarly journals Endotoxin depresses heart rate variability in mice: cytokine and steroid effects

2009 ◽  
Vol 297 (4) ◽  
pp. R1019-R1027 ◽  
Author(s):  
Karen D. Fairchild ◽  
Jeffrey J. Saucerman ◽  
Laura L. Raynor ◽  
Joseph A. Sivak ◽  
Yuping Xiao ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
High Frequency ◽  
High Dose ◽  
Biphasic Response ◽  
Dexamethasone Treatment ◽  
Life Threatening ◽  
Surgical Implantation ◽  
Temporally Correlated

Heart rate variability (HRV) falls in humans with sepsis, but the mechanism is not well understood. We utilized a mouse model of endotoxemia to test the hypothesis that cytokines play a role in abnormal HRV during sepsis. Adult male C57BL/6 mice underwent surgical implantation of probes to continuously monitor electrocardiogram and temperature or blood pressure via radiotelemetry. Administration of high-dose LPS ( Escherichia coli LPS, 10 mg/kg, n = 10) caused a biphasic response characterized by an early decrease in temperature and heart rate at 1 h in some mice, followed by a prolonged period of depressed HRV in all mice. Further studies showed that LPS doses as low as 0.01 mg/kg evoked a significant decrease in HRV. With high-dose LPS, the initial drops in temperature and HR were temporally correlated with peak expression of TNFα 1 h post-LPS, whereas maximal depression in HRV coincided with peak levels of multiple other cytokines 3–9 h post-LPS. Neither hypotension nor hypothermia explained the HRV response. Pretreatment with dexamethasone prior to LPS significantly blunted expression of 7 of the 10 cytokines studied and shortened the duration of depressed HRV by about half. Interestingly, dexamethasone treatment alone caused a dramatic increase in both low- and high-frequency HRV. Administration of recombinant TNFα caused a biphasic response in HR and HRV similar to that caused by LPS. Understanding the role of cytokines in abnormal HRV during sepsis could lead to improved strategies for detecting life-threatening nosocomial infections in intensive care unit patients.

Multiscale rhythmic influences on heart rate variability in human endotoxemia

2012 ◽  
Vol 27 (3) ◽  
pp. e3
Author(s):  
Jeremy D. Scheff ◽  
Steve E. Calvano ◽  
Stephen F. Lowry ◽  
Ioannis P. Androulakis
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Human Endotoxemia

The relationship between autonomic function and heart rate variability in human endotoxemia

2013 ◽  
Vol 28 (6) ◽  
pp. e32
Author(s):  
Jeremy Scheff ◽  
Siobhan Corbett ◽  
Steve Calvano ◽  
Ioannis Androulakis
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Autonomic Function ◽  
Human Endotoxemia ◽  
The Relationship

scholarly journals Modeling autonomic regulation of cardiac function and heart rate variability in human endotoxemia

2011 ◽  
Vol 43 (16) ◽  
pp. 951-964 ◽  
Author(s):  
Jeremy D. Scheff ◽  
Panteleimon D. Mavroudis ◽  
Steven E. Calvano ◽  
Stephen F. Lowry ◽  
Ioannis P. Androulakis
Keyword(s):  
Mathematical Model ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Stress Responses ◽  
Acute Stress ◽  
Inflammatory Diseases ◽  
Biological Processes ◽  
Cellular Mechanisms ◽  
Human Endotoxemia ◽  
The Relationship

Heart rate variability (HRV), the quantification of beat-to-beat variability, has been studied as a potential prognostic marker in inflammatory diseases such as sepsis. HRV normally reflects significant levels of variability in homeostasis, which can be lost under stress. Much effort has been placed in interpreting HRV from the perspective of quantitatively understanding how stressors alter HRV dynamics, but the molecular and cellular mechanisms that give rise to both homeostatic HRV and changes in HRV have received less focus. Here, we develop a mathematical model of human endotoxemia that incorporates the oscillatory signals giving rise to HRV and their signal transduction to the heart. Connections between processes at the cellular, molecular, and neural levels are quantitatively linked to HRV. Rhythmic signals representing autonomic oscillations and circadian rhythms converge to modulate the pattern of heartbeats, and the effects of these oscillators are diminished in the acute endotoxemia response. Based on the semimechanistic model developed herein, homeostatic and acute stress responses of HRV are studied in terms of these oscillatory signals. Understanding the loss of HRV in endotoxemia serves as a step toward understanding changes in HRV observed clinically through translational applications of systems biology based on the relationship between biological processes and clinical outcomes.

T158. High-Dose Theta-Burst Transcranial Magnetic Stimulation Modulates Heart Rate Variability

2018 ◽  
Vol 83 (9) ◽  
pp. S189
Author(s):  
Jaspreet Pannu ◽  
Elisa Kallioniemi ◽  
Merve Gulser ◽  
Katy Stimpson ◽  
Danielle DeSouza ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
High Dose ◽  
Theta Burst

Chronic high dose captopril decreases total heart rate variability and increases heart rate in C57BL/6J mice

2009 ◽  
Vol 136 (2) ◽  
pp. 211-213 ◽  
Author(s):  
F. Touma ◽  
V.S.P. Chew ◽  
W.C. Chua ◽  
H. Jelinek ◽  
P.T. Wong ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
High Dose

Autonomic Nervous System Responses during Sedative Infusions of Dexmedetomidine

2002 ◽  
Vol 97 (3) ◽  
pp. 592-598 ◽  
Author(s):  
Charles W. Hogue ◽  
Pekka Talke ◽  
Phyllis K. Stein ◽  
Charles Richardson ◽  
Peter P. Domitrovich ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Baroreflex Sensitivity ◽  
Control Period ◽  
Plasma Norepinephrine ◽  
High Dose ◽  
Autonomic Responses ◽  
Sweating Threshold ◽  
Dexmedetomidine Infusion

Background The purpose of this study was to determine the effects of dexmedetomidine on systemic and cardiac autonomic reflex responses during rest and during thermal stress. Methods Volunteers received either placebo or low- or high-dose dexmedetomidine (target plasma concentrations 0.3 or 0.6 ng/ml, respectively) infusions in a prospectively randomized, double-blinded crossover study design. After 1 h, baroreflex sensitivity was assessed, and then core body temperature was raised to the sweating threshold and then lowered to the shivering threshold. Plasma catecholamines and blood pressure were measured, and cardiac autonomic responses were assessed by analysis of heart rate variability. Results Compared with placebo, plasma norepinephrine concentrations, blood pressure, heart rate, and some heart rate variability measures were lower after 1-h infusion of dexmedetomidine, but baroreflex responses did not differ significantly. Dexmedetomidine blunted the systemic and cardiac sympathetic effects of sweating observed during placebo infusion but had no effect on parasympathetic measures. Increases in blood pressure, and systemic catecholamines due to shivering were observed during placebo and dexmedetomidine, but these responses were less with dexmedetomidine. During shivering, dexmedetomidine infusion was associated with higher low-frequency and high-frequency heart rate variability power but lower heart rate compared with the sweating threshold and with the control period, suggesting nonreciprocal cardiac autonomic responses. Conclusions Infusion of dexmedetomidine results in compensated reductions in systemic sympathetic tone without changes in baroreflex sensitivity. Dexmedetomidine blunts heart rate and the systemic sympathetic activation due to sweating, but it is less effective in blunting cardiac sympathetic responses to shivering. During dexmedetomidine infusion, cardiac sympathetic and parasympathetic tone may have nonreciprocal changes during shivering.

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