Oral Candida Infection in Psoriatic Patients Treated with IL17A Inhibitors: Report of 3 Cases and a Comprehensive Review of the Literature

An intact and fully functional immune system plays a crucial role in the prevention of several infectious diseases. Interleukin (IL)17 is significantly involved in oral mucosa immunity against several antigens and microorganisms, including Candida albicans (CA). Herein, we present three cases of oral candidiasis (OC) related to the use of an IL17A inhibitor for psoriasis. Three psoriatic individuals presented for evaluation of widespread symptomatic oral lesions temporally correlated with the onset of IL17A inhibitors (secukinumab in two patients and brodalumab in one patient). Clinical examination revealed either partially removable white plaques in an erythematous background (case #1) or diffuse erythematous lesions (cases #2 and 3) involving several areas of the oral mucosa. Cytology smear, accompanied by histopathologic examination in case #1, confirmed the clinical impression of OC in all three cases. All patients received antifungal therapy with satisfactory clinical response. No discontinuation of the antipsoriatic regimen was recommended, but all patients were advised to remain under monitoring for possible OC relapses. During the last few years, new systemic biologic agents targeting IL17 have been used for the management of variable immune-mediated diseases. Few clinical trials and scarce case reports have shown that these medications place individuals at high risk of developing candidiasis. We propose that patients treated with these medications should be at close monitoring for the development of OC and, if it occurs, receive appropriate management.

Simultaneous selection on vegetative and reproductive phenology in a perennial herb

The timing of different life history events are often correlated, and selection might only rarely be exerted independently on the timing of a single event. In plants, phenotypic selection has often been shown to favour earlier flowering. However, little is known about to what extent this selection acts directly vs. indirectly via vegetative phenology, and if selection on the two traits is correlational. We estimated direct, indirect and correlational phenotypic selection on vegetative and reproductive phenology over three years for the perennial herb Lathyrus vernus. Direct selection favoured earlier flowering and shorter timespans between leaf-out and flowering in all years. However, early flowering was associated with early leaf-out, and the direction of selection on leaf-out day varied among years. As a result, selection on leaf-out weakened selection for early flowering in one of the study years. We found no evidence of correlational selection. Our results highlight the importance of including temporally correlated traits when exploring selection on the phenology of seasonal events.

Analysis of Type II radio burst relationship with CME driven shocks

Type II radio bursts are known to be the signatures of coronal shocks. In this paper we examine the relationship between 129 type II bursts in the frequency range 35 – 450 MHz observed at Culgooora observatory during May 2002 – October 2015 and the associated CMEs. We apply Newkirk (1961) density model to determine the formation height of type IIs. We find that in 109/129 cases, type II bursts were preceded/ succeeded by CMEs. The CME associated type II events in which the CME height is above the type II burst source are categorized as group I events (91/129 cases). 91% of the bursts in this group are also associated with flares and 58% of these bursts originate during decaying phase of the flare. The correlation between CME speed and type II shock speed for limb events in this group is 0.33.The CME associated type IIs in which the CME height is below the type II source are categorized as group II (18/129 cases). CME driven shock could have been the exciter of these type II bursts.88% of this group events are associated with flares and 62% of these bursts originate during the rising phase of the flare. The correlation between CME speed and type II shock speed for limb events in this group is 0.96. In 20/129 cases of our data set, type II bursts are not associated with CME and are categorized as group III. 90% of the bursts in this group are associated with flares. 77% of the bursts in the group are originating in the decaying phase of flares. Poor temporal association (9/69 cases) between type IIs and flares of X class during this period. Our results suggest that inspite of temporal association with metric type II bursts, majority of the CME driven shocks (84%) are not successful in exciting type II bursts in 35-450 MHz domain. The type II bursts temporally correlated with CMEs and likely to have been excited by CMEs (type II height > CME height) are originating during the rising phase of the flares in majority of the events. In case of type II bursts temporally correlated with CMEs supposedly not excited by the CMEs (type II height < CME height) ,majority of them are originating in the decaying phase of flares.

Investigating site-selection mechanisms of retroviral integration in supercoiled DNA braids

We theoretically study the integration of short viral DNA in a DNA braid made up by two entwined double-stranded DNA molecules. We show that the statistics of single integration events substantially differ in the straight and buckled, or plectonemic, phase of the braid and are more likely in the latter. We further discover that integration is most likely close to plectoneme tips, where the larger bending energy helps overcome the associated energy barrier and that successive integration events are spatio-temporally correlated, suggesting a potential mechanistic explanation of clustered integration sites in host genomes. The braid geometry we consider provides a novel experimental set-up to quantify integration in a supercoiled substrate in vitro , and to better understand the role of double-stranded DNA topology during this process.

Confinement of long-lived interlayer excitons in WS2/WSe2 heterostructures

Interlayer excitons in layered materials constitute a novel platform to study many-body phenomena arising from long-range interactions between quantum particles. Long-lived excitons are required to achieve high particle densities, to mediate thermalisation, and to allow for spatially and temporally correlated phases. Additionally, the ability to confine them in periodic arrays is key to building a solid-state analogue to atoms in optical lattices. Here, we demonstrate interlayer excitons with lifetime approaching 0.2 ms in a layered-material heterostructure made from WS2 and WSe2 monolayers. We show that interlayer excitons can be localised in an array using a nano-patterned substrate. These confined excitons exhibit microsecond-lifetime, enhanced emission rate, and optical selection rules inherited from the host material. The combination of a permanent dipole, deterministic spatial confinement and long lifetime places interlayer excitons in a regime that satisfies one of the requirements for simulating quantum Ising models in optically resolvable lattices.

Recurrence-mediated suprathreshold stochastic resonance

It has previously been shown that the encoding of time-dependent signals by feedforward networks (FFNs) of processing units exhibits suprathreshold stochastic resonance (SSR), which is an optimal signal transmission for a finite level of independent, individual stochasticity in the single units. In this study, a recurrent spiking network is simulated to demonstrate that SSR can be also caused by network noise in place of intrinsic noise. The level of autonomously generated fluctuations in the network can be controlled by the strength of synapses, and hence the coding fraction (our measure of information transmission) exhibits a maximum as a function of the synaptic coupling strength. The presence of a coding peak at an optimal coupling strength is robust over a wide range of individual, network, and signal parameters, although the optimal strength and peak magnitude depend on the parameter being varied. We also perform control experiments with an FFN illustrating that the optimized coding fraction is due to the change in noise level and not from other effects entailed when changing the coupling strength. These results also indicate that the non-white (temporally correlated) network noise in general provides an extra boost to encoding performance compared to the FFN driven by intrinsic white noise fluctuations.