Clinical usefulness of best-fit toric ellipsoid reference body in ectatic and crosslinked corneas

Purpose. To establish which reference body offers the greatest sensitivity in keratoconus (KC) diagnosis, obtain normative data for the myopic population with toric ellipsoid reference bodies, and determine the cutoff points for a population with KC.Methods. A retrospective, observational study of the entire Scheimpflug tomographer database of the Fundación Jiménez Díaz in Madrid was conducted to identify a normal myopic and a KC myopic population. Three different reference bodies were tested on all patients: best fit sphere (BFS), best fit toric ellipsoid with fixed eccentricity (BFTEFE), and best fit toric ellipsoid (BFTE). Anterior and posterior elevation measurements at the apex and thinnest point were recorded, as well as the root mean square of posterior elevations (RMS-P). Normative data were extracted, and receiver operating characteristic (ROC) curves were generated to obtain cutoff points between the normal and KC population.Results. A total of 301 eyes were included, comprising 219 normal myopic and 82 myopic KC eyes. BFS and BFTEFE produced the best results when measuring posterior elevation at the thinnest point. BFTE had better sensitivity with the RMS-P. From all measurements, best sensitivity (100%) was achieved with a cutoff point of 8 μm of posterior elevation at the thinnest point using the BFTEFE. BFTE was found to hide the cone in certain patients.Conclusions. Posterior elevation measured at the thinnest point with a BFTEFE is the best-performing parameter and, therefore, is recommended to discriminate between normal and KC patients within a myopic population.

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Localization of Gallium-67 in Peritoneal Cells by Electron Microscopic Autoradiography

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100072460 ◽

1973 ◽

Vol 31 ◽

pp. 404-405

Author(s):

D. C. Swartzendruber ◽

Norma L. Idoyaga-Vargas

Keyword(s):

Clinical Trials ◽

Soft Tissue ◽

Tumor Tissue ◽

Soft Tissue Tumors ◽

Clinical Usefulness ◽

Electron Microscopic ◽

Normal Cells ◽

Electron Microscopic Autoradiography ◽

Peritoneal Cells ◽

Gallium 67

The radionuclide gallium-67 (67Ga) localizes preferentially but not specifically in many human and experimental soft-tissue tumors. Because of this localization, 67Ga is used in clinical trials to detect humar. cancers by external scintiscanning methods. However, the fact that 67Ga does not localize specifically in tumors requires for its eventual clinical usefulness a fuller understanding of the mechanisms that control its deposition in both malignant and normal cells. We have previously reported that 67Ga localizes in lysosomal-like bodies, notably, although not exclusively, in macrophages of the spocytaneous AKR thymoma. Further studies on the uptake of 67Ga by macrophages are needed to determine whether there are factors related to malignancy that might alter the localization of 67Ga in these cells and thus provide clues to discovering the mechanism of 67Ga localization in tumor tissue.

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Question Wording Effects in the Assessment of Global Self-Esteem

European Journal of Psychological Assessment ◽

10.1027//1015-5759.16.1.13 ◽

2000 ◽

Vol 16 (1) ◽

pp. 13-19 ◽

Cited By ~ 31

Author(s):

Martin Dunbar ◽

Graeme Ford ◽

Kate Hunt ◽

Geoff Der

Keyword(s):

Reading Ability ◽

Factor Model ◽

Self Esteem ◽

Reading Scores ◽

Poor Reading ◽

Method Effect ◽

Two Samples ◽

Positive Item ◽

Method Effects ◽

Best Fit

Summary: Marsh (1996) produced evidence that method effects associated with negatively worded items might be responsible for the results of earlier factor analytic studies that reported finding positive and negative self-esteem factors in the Rosenberg Global self-esteem scale ( Rosenberg, 1965 ). He analyzed data collected from children using a 7-item self-esteem measure. This report details attempts to replicate Marsh 's analysis in data collected from two samples of adults who completed the full 10-item Global Self-Esteem (GSE) scale. The results reported here are similar to those given by Marsh in so much as a correlated uniquenesses model produced a superior fit to the data than the simple one factor model (without correlated uniquenesses) or the often reported two factor (positive and negative self-esteem) model. However, whilst Marsh reported that the best fit was produced by allowing negative item uniquenesses to correlate with each other, the model that produced the best fit to these data was one that contained correlated positive item uniquenesses. Supporting his claim that differential responding to negative and positive self-esteem items reflects a method effect associated with reading ability, Marsh also showed that factors associated with negative and positive items were most distinct among children who had poor reading scores. We report a similar effect among a sample of older adults where the correlation between these factors was compared across two groups who were selected according to their scores on a test of verbal reasoning.

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Clinical usefulness of PIVKA-II measured by sensitive enzyme immunoassay and AFP-L3 measured by automated analyzer in the diagnosis of hepatocellular carcinoma (HCC)

Journal of Hepatology ◽

10.1016/s0168-8278(01)80350-0 ◽

2001 ◽

Vol 34 (0) ◽

pp. 98-99

Author(s):

Y Paik

Keyword(s):

Hepatocellular Carcinoma ◽

Enzyme Immunoassay ◽

Clinical Usefulness

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Clinical usefulness of KRAS gene mutation analysis, in EUS-FNA specimens from pancreatic mass lesions

Endoscopy ◽

10.1055/s-0031-1292199 ◽

2011 ◽

Vol 43 (S 03) ◽

Author(s):

Ogura Takeshi

Keyword(s):

Gene Mutation ◽

Mutation Analysis ◽

Clinical Usefulness ◽

Pancreatic Mass ◽

Kras Gene ◽

Mass Lesions ◽

Gene Mutation Analysis

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Direct Assessment of Effective Renal Plasma Flow from Renoscintigraphy with a Gamma Camera and an On-Line Computer

Nuklearmedizin ◽

10.1055/s-0037-1620658 ◽

1981 ◽

Vol 20 (06) ◽

pp. 274-278

Author(s):

J. Liniecki ◽

J. Bialobrzeski ◽

Ewa Mlodkowska ◽

M. J. Surma

Keyword(s):

Count Rate ◽

Renal Plasma Flow ◽

Early Period ◽

Least Square Method ◽

Least Square ◽

Uptake Coefficient ◽

Positive Linear Correlation ◽

On Line ◽

Best Fit ◽

Plasma Activity

A concept of a kidney uptake coefficient (UC) of 131I-o-hippurate was developed by analogy from the corresponding kidney clearance of blood plasma in the early period after injection of the hippurate. The UC for each kidney was defined as the count-rate over its ROI at a time shorter than the peak in the renoscintigraphic curve divided by the integral of the count-rate curve over the "blood"-ROI. A procedure for normalization of both curves against each other was also developed. The total kidney clearance of the hippurate was determined from the function of plasma activity concentration vs. time after a single injection; the determinations were made at 5, 10, 15, 20, 30, 45, 60, 75 and 90 min after intravenous administration of 131I-o-hippurate and the best-fit curve was obtained by means of the least-square method. When the UC was related to the absolute value of the clearance a positive linear correlation was found (r = 0.922, ρ > 0.99). Using this regression equation the clearance could be estimated in reverse from the uptake coefficient calculated solely on the basis of the renoscintigraphic curves without blood sampling. The errors of the estimate are compatible with the requirement of a fast appraisal of renal function for purposes of clinical diagknosis.

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